| 9/5/2009 | Youngstown St 3 @ Pittsburgh 38 | |
| 9/12/2009 | Pittsburgh 54 @ Buffalo 27 | |
| 9/19/2009 | Navy 14 @ Pittsburgh 27 | |
| 9/26/2009 | Pittsburgh 31 @ North Carolina St 38 | |
| 10/2/2009 | Pittsburgh 35 @ Louisville 10 | † |
| 10/10/2009 | Connecticut 21 @ Pittsburgh 24 | † |
| 10/16/2009 | Pittsburgh 24 @ Rutgers 17 | † |
| 10/24/2009 | South Florida 14 @ Pittsburgh 41 | † |
| 11/7/2009 | Syracuse 10 @ Pittsburgh 37 | † |
| 11/14/2009 | Notre Dame 22 @ Pittsburgh 27 | |
| 11/27/2009 | Pittsburgh 16 @ West Virginia 19 | † |
| 12/5/2009 | Cincinnati 45 @ Pittsburgh 44 | † |
| 12/26/2009 | Pittsburgh 19 vs North Carolina 17 (Meineke Bowl) |