| Thursday, 30 Oct 2008 |
| BigE | South Florida | 10 | @ | Cincinnati | 24 | | |
| LSC | Angelo St (D2) | 24 | @ | Tarleton St (D2) | 31 | | |
| GSC | West Georgia (D2) | 14 | @ | Valdosta St (D2) | 41 | | |
| Friday, 31 Oct 2008 |
| SoCon | Wofford | 24 | @ | Appalachian St | 70 | | |
| Minnesota-Morris (NAIA) | 0 | vs | Macalester (D3) | 25 | | Minneapolis MN |
| UMWAC | St Scholastica (D3) | 42 | vs | Martin Luther (NAIA) | 77 | | Minneapolis MN |
| UMWAC | Crown (NAIA) | 7 | vs | Northwestern MN (NAIA) | 44 | | Minneapolis MN |
| Saturday, 1 Nov 2008 |
| Arkansas St | 0 | @ | #4 Alabama | 35 | | |
| NE | Monmouth NJ | 17 | @ | Albany NY | 35 | | |
| SWAC | Alabama St | 24 | @ | Alcorn St | 17 | | |
| MIAA | Adrian (D3) | 45 | @ | Alma (D3) | 24 | | |
| HCA | Bluffton (D3) | 10 | @ | Anderson (D3) | 38 | | |
| Webber Int'l (NAIA) | 13 | @ | Apprentice (D3) | 10 | | |
| Tulsa | 23 | @ | Arkansas | 30 | | |
| Air Force | 16 | @ | Army | 7 | | |
| MIA | St Thomas (D3) | 20 | @ | Augsburg (D3) | 22 | | |
| CCIW | North Park (D3) | 0 | @ | Augustana IL (D3) | 52 | | |
| Wisconsin Lutheran (D3) | 6 | @ | Aurora (D3) | 51 | | |
| DePauw (D3) | 31 | @ | Austin (D3) | 28 | | |
| HAAC | MidAmerica Nazarene (NAIA) | 38 | @ | Avila (NAIA) | 0 | | |
| Central Washington (D2) | 36 | @ | Azusa Pacific (NAIA) | 6 | | |
| HAAC | Missouri Valley (NAIA) | 22 | @ | Baker (NAIA) | 26 | | |
| OAC | Ohio Northern (D3) | 7 | @ | Baldwin-Wallace (D3) | 10 | | |
| B12 | #13 Missouri | 31 | @ | Baylor | 28 | | |
| MSC | Lambuth (NAIA) | 63 | @ | Belhaven (NAIA) | 13 | | |
| MidW | St Norbert (D3) | 42 | @ | Beloit (D3) | 21 | | |
| NSIC | Mary (D2) | 10 | @ | Bemidji St (D2) | 31 | | |
| SIAC | Kentucky St (D2) | 35 | @ | Benedict (D2) | 42 | | |
| Rockford (D3) | 14 | @ | Benedictine IL (D3) | 20 | | |
| HAAC | William Jewell (NAIA) | 3 | @ | Benedictine KS (NAIA) | 47 | | |
| NE10 | Pace (D2) | 20 | @ | Bentley (D2) | 24 | | |
| KCAC | St Mary KS (NAIA) | 26 | @ | Bethany KS (NAIA) | 42 | | |
| Geneva (NAIA) | 38 | @ | Bethany WV (D3) | 23 | | |
| MIA | Gustavus Adolphus (D3) | 17 | @ | Bethel MN (D3) | 10 | | |
| MEAC | North Carolina A&T | 14 | @ | Bethune-Cookman | 24 | | |
| PSAC | West Chester (D2) | 24 | @ | Bloomsburg (D2) | 21 | | |
| ACC | Clemson | 27 | @ | Boston College | 21 | | |
| NESCAA | Bates (D3) | 14 | @ | Bowdoin (D3) | 55 | | |
| CIAA | Virginia St (D2) | 16 | @ | Bowie St (D2) | 21 | | |
| MAC | Kent St | 30 | @ | Bowling Green | 45 | | |
| GPAC | Dordt (NAIA) | 16 | @ | Briar Cliff (NAIA) | 27 | | |
| ODC | Washington and Lee (D3) | 19 | @ | Bridgewater VA (D3) | 32 | | |
| Duquesne | 10 | @ | Bryant (D2) | 24 | | |
| Pio | Jacksonville FL | 45 | @ | Butler | 9 | | |
| SCIAC | Occidental (D3) | 24 | @ | Cal Lutheran (D3) | 21 | | |
| Idaho St | 10 | @ | Cal Poly SLO | 49 | | |
| P10 | Oregon | 16 | @ | #21 California | 26 | | |
| Pio | Davidson | 49 | @ | Campbell | 0 | | |
| MSC | Cumberlands KY (NAIA) | 34 | @ | Campbellsville (NAIA) | 27 | | |
| OAC | Muskingum (D3) | 10 | @ | Capital (D3) | 42 | | |
| MIA | Hamline (D3) | 27 | @ | Carleton (D3) | 28 | | |
| MidW | Lawrence (D3) | 14 | @ | Carroll WI (D3) | 34 | | |
| SAC | Wingate (D2) | 33 | @ | Carson-Newman (D2) | 35 | | |
| UAA | Chicago (D3) | 24 | @ | Case Western Reserve (D3) | 38 | | |
| Brevard (D2) | 10 | @ | Catawba (D2) | 24 | | |
| IIAC | Loras (D3) | 31 | @ | Central IA (D3) | 28 | | |
| MAIAA | Missouri Western (D2) | 42 | @ | Central Missouri (D2) | 41 | | |
| LSC | East Central OK (D2) | 17 | @ | Central Oklahoma (D2) | 30 | | |
| BigS | VMI | 21 | @ | Charleston Southern | 31 | | |
| Chapman (D3) | 21 | @ | Claremont-Mudd-Scripps (D3) | 7 | | |
| PSAC | Edinboro (D2) | 35 | @ | Clarion (D2) | 10 | | |
| SIAC | Tuskegee (D2) | 42 | @ | Clark Atlanta (D2) | 20 | | |
| IIAC | Buena Vista (D3) | 19 | @ | Coe (D3) | 10 | | |
| Pat | Lafayette | 13 | @ | Colgate | 21 | | |
| Birmingham-Southern (D3) | 31 | @ | Colorado College (D3) | 17 | | |
| RMAC | Nebraska-Kearney (D2) | 20 | @ | Colorado Mines (D2) | 37 | | |
| MW | #22 Brigham Young | 45 | @ | Colorado St | 42 | | |
| GPAC | Dana (NAIA) | 17 | @ | Concordia NE (NAIA) | 10 | | |
| IBC | Concordia IL (D3) | 13 | @ | Concordia WI (D3) | 46 | | |
| MIA | St Olaf (D3) | 28 | @ | Concordia-Moorhead (D3) | 25 | | |
| BigE | West Virginia | 35 | @ | Connecticut | 13 | | |
| Ivy | Princeton | 31 | @ | Cornell NY | 26 | | |
| HAAC | Central Methodist (NAIA) | 38 | @ | Culver-Stockton (NAIA) | 6 | | |
| MSC | Shorter (NAIA) | 27 | @ | Cumberland TN (NAIA) | 24 | | |
| NEF | Nichols (D3) | 20 | @ | Curry (D3) | 45 | | |
| Ivy | Harvard | 35 | @ | Dartmouth | 7 | | |
| MEAC | South Carolina St | 23 | @ | Delaware St | 17 | | |
| MidAC | Widener (D3) | 28 | @ | Delaware Valley (D3) | 34 | | |
| GSC | Arkansas Tech (D2) | 14 | @ | Delta St (D2) | 48 | | |
| Cen | Muhlenberg (D3) | 31 | @ | Dickinson (D3) | 25 | | |
| DAC | Dakota St (NAIA) | 15 | @ | Dickinson St (NAIA) | 29 | | |
| Western Washington (D2) | 20 | @ | Dixie St (D2) | 14 | | |
| GPAC | Morningside (NAIA) | 49 | @ | Doane (NAIA) | 27 | | |
| IIAC | Simpson (D3) | 35 | @ | Dubuque (D3) | 26 | | |
| ASWC | Mary Hardin-Baylor (D3) | 27 | @ | East Texas Baptist (D3) | 6 | | |
| OVC | Murray St | 6 | @ | Eastern Illinois | 34 | | |
| BSky | Sacramento St | 15 | @ | Eastern Washington | 13 | | |
| CIAA | Virginia Union (D2) | 13 | @ | Elizabeth City St (D2) | 36 | | |
| CCIW | Wheaton (D3) | 23 | @ | Elmhurst (D3) | 37 | | |
| ODC | Catholic (D3) | 38 | @ | Emory & Henry (D3) | 23 | | |
| NEF | UMass-Dartmouth (D3) | 53 | @ | Endicott (D3) | 35 | | |
| Seton Hill (NAIA) | 41 | @ | Fairmont St (D2) | 38 | | |
| West Virginia Tech (D2) | 15 | @ | Faulkner (NAIA) | 26 | | |
| CIAA | Livingstone (D2) | 20 | @ | Fayetteville St (D2) | 55 | | |
| MidAC | Lycoming (D3) | 48 | @ | FDU-Florham (D3) | 28 | | |
| GLIAC | Saginaw Valley St (D2) | 17 | @ | Findlay (D2) | 9 | | |
| NEF | Westfield St (D3) | 37 | @ | Fitchburg St (D3) | 30 | | |
| SEC | #11 Georgia | 10 | vs | #3 Florida | 49 | | Jacksonville FL |
| MEAC | Morgan St | 13 | @ | Florida A&M | 10 | | |
| Marist | 21 | @ | Fordham | 45 | | |
| RMAC | New Mexico Highlands (D2) | 17 | @ | Fort Lewis (D2) | 3 | | |
| SIAC | Albany St GA (D2) | 31 | @ | Fort Valley St (D2) | 7 | | |
| Rose-Hulman (D3) | 7 | @ | Franklin (D3) | 42 | | |
| Cen | McDaniel (D3) | 0 | @ | Franklin & Marshall (D3) | 20 | | |
| KCAC | McPherson (NAIA) | 17 | @ | Friends (NAIA) | 41 | | |
| D3Ind | Mount Ida (D3) | 38 | @ | Gallaudet (D3) | 7 | | |
| Indiana PA (D2) | 35 | @ | Gannon (D2) | 10 | | |
| Pat | Lehigh | 33 | @ | Georgetown DC | 13 | | |
| ACC | Florida St | 28 | @ | #22 Georgia Tech | 31 | | |
| NAIAInd | Waldorf (NAIA) | 14 | @ | Grand View (NAIA) | 62 | | |
| USASC | Ferrum (D3) | 46 | @ | Greensboro (D3) | 21 | | |
| NESCAA | Middlebury (D3) | 31 | @ | Hamilton (D3) | 28 | | |
| MEAC | Winston-Salem St | 35 | @ | Hampton | 30 | | |
| HCA | Defiance (D3) | 31 | @ | Hanover (D3) | 28 | | |
| E8 | Norwich (D3) | 12 | @ | Hartwick (D3) | 42 | | |
| OAC | Wilmington (D3) | 23 | @ | Heidelberg (D3) | 20 | | |
| GSC | Harding (D2) | 32 | @ | Henderson St (D2) | 33 | | |
| GLIAC | Ferris St (D2) | 14 | @ | Hillsdale (D2) | 34 | | |
| LL | WPI (D3) | 14 | @ | Hobart (D3) | 31 | | |
| Pat | Bucknell | 17 | @ | Holy Cross | 34 | | |
| MIAA | Olivet (D3) | 13 | @ | Hope (D3) | 38 | | |
| MEAC | Norfolk St | 49 | @ | Howard | 12 | | |
| ASWC | Mississippi College (D3) | 30 | @ | Howard Payne (D3) | 14 | | |
| Principia (D3) | 0 | @ | Huntingdon (D3) | 76 | | |
| WAC | San Jose St | 30 | @ | Idaho | 24 | | |
| B10 | Iowa | 24 | @ | Illinois | 27 | | |
| MidW | Monmouth IL (D3) | 78 | @ | Illinois College (D3) | 17 | | |
| MVC | Youngstown St | 44 | @ | Illinois St | 54 | | |
| Central Michigan | 37 | @ | Indiana | 34 | | |
| GLIAC | Ashland (D2) | 44 | @ | Indianapolis (D2) | 37 | | |
| E8 | Springfield (D3) | 8 | @ | Ithaca (D3) | 37 | | |
| OVC | Austin Peay | 22 | @ | Jacksonville St | 35 | | |
| CAAF | Delaware | 7 | @ | James Madison | 41 | | |
| DAC | Black Hills St (NAIA) | 29 | @ | Jamestown (NAIA) | 24 | | |
| Juniata (D3) | 0 | @ | Johns Hopkins (D3) | 12 | | |
| CIAA | Shaw (D2) | 62 | @ | Johnson C. Smith (D2) | 35 | | |
| B12 | Kansas St | 21 | @ | Kansas | 52 | | |
| KCAC | Sterling (NAIA) | 26 | @ | Kansas Wesleyan (NAIA) | 19 | | |
| Lake Erie (D2) | 38 | @ | Kentucky Wesleyan (D2) | 31 | | |
| NCA | Earlham (D3) | 49 | @ | Kenyon (D3) | 42 | | |
| MidW | Lake Forest (D3) | 28 | @ | Knox (D3) | 37 | | |
| C.W. Post (D2) | 14 | @ | Kutztown (D2) | 21 | | |
| Eureka (D3) | 19 | @ | LaGrange (D3) | 63 | | |
| SIAC | Miles (D2) | 2 | @ | Lane (D2) | 52 | | |
| SW Assem of God (NAIA) | 7 | @ | Langston (D2) | 41 | | |
| MidAC | Albright (D3) | 31 | @ | Lebanon Valley (D3) | 14 | | |
| Menlo (D3) | 49 | @ | Lewis & Clark (D3) | 20 | | |
| GLFC | Missouri S&T (D2) | 68 | @ | Lincoln MO (D2) | 0 | | |
| CIAA | St Paul's (D2) | 23 | @ | Lincoln PA (D2) | 20 | | |
| HAAC | Evangel (NAIA) | 7 | @ | Lindenwood (NAIA) | 56 | | |
| WAC | Fresno St | 35 | @ | Louisiana Tech | 38 | | |
| SBC | Florida Int'l | 20 | @ | Louisiana-Lafayette | 49 | | |
| SBC | Troy | 30 | @ | Louisiana-Monroe | 31 | | |
| Tulane | 10 | @ | #23 LSU | 35 | | |
| Blackburn (D3) | 10 | @ | MacMurray (D3) | 17 | | |
| Iona | 7 | @ | Maine | 55 | | |
| Coast Guard (D3) | 34 | @ | Maine Maritime (D3) | 42 | | |
| MSFA | St Xavier (NAIA) | 23 | @ | Malone (NAIA) | 27 | | |
| Lakeland (D3) | 29 | @ | Maranatha Baptist (D3) | 14 | | |
| SAC | Tusculum (D2) | 33 | @ | Mars Hill (D2) | 28 | | |
| NEF | Framingham St (D3) | 19 | @ | Mass Maritime (D3) | 17 | | |
| California PA (D2) | 17 | @ | Mercyhurst (D2) | 6 | | |
| NE10 | American Int'l (D2) | 34 | @ | Merrimack (D2) | 29 | | |
| RMAC | Chadron St (D2) | 27 | @ | Mesa St (D2) | 16 | | |
| Maryville (D3) | 38 | @ | Methodist (D3) | 0 | | |
| B10 | Wisconsin | 24 | @ | #17 Michigan St | 25 | | |
| Tiffin (D2) | 28 | @ | Michigan Tech (D2) | 32 | | |
| GPAC | Nebraska Wesleyan (NAIA) | 19 | @ | Midland Lutheran (NAIA) | 17 | | |
| LSC | Eastern New Mexico (D2) | 16 | @ | Midwestern St (D2) | 59 | | |
| PSAC | East Stroudsburg (D2) | 45 | @ | Millersville (D2) | 18 | | |
| CCIW | Carthage (D3) | 17 | @ | Millikin (D3) | 13 | | |
| Upper Iowa (D2) | 14 | @ | Minn St-Mankato (D2) | 35 | | |
| B10 | #25 Northwestern | 24 | @ | #24 Minnesota | 17 | | |
| Minnesota-Duluth (D2) | 63 | @ | Minnesota-Crookston (D2) | 7 | | |
| DAC | Mayville St (NAIA) | 13 | @ | Minot St (NAIA) | 41 | | |
| SEC | Auburn | 7 | @ | Mississippi | 17 | | |
| SEC | Kentucky | 14 | @ | Mississippi St | 13 | | |
| SWAC | Grambling St | 35 | @ | Mississippi Valley St | 14 | | |
| Plymouth St (D3) | 27 | @ | MIT (D3) | 14 | | |
| BSky | Northern Arizona | 10 | @ | Montana | 45 | | |
| BSky | Northern Colorado | 7 | @ | Montana St | 20 | | |
| Front | Montana-Western (NAIA) | 28 | @ | Montana St-Northern (NAIA) | 38 | | |
| Front | Carroll MT (NAIA) | 10 | @ | Montana Tech (NAIA) | 6 | | |
| Ursinus (D3) | 7 | @ | Moravian (D3) | 17 | | |
| Pio | Valparaiso | 10 | @ | Morehead St | 44 | | |
| Brockport St (D3) | 55 | @ | Morrisville St (D3) | 19 | | |
| OAC | John Carroll (D3) | 7 | @ | Mount Union (D3) | 41 | | |
| HCA | Manchester (D3) | 6 | @ | Mt St Joseph (D3) | 28 | | |
| Temple | 27 | @ | Navy | 33 | OT | |
| Fort Hays St (D2) | 14 | @ | Nebraska-Omaha (D2) | 27 | | |
| CAAF | Hofstra | 25 | @ | New Hampshire | 45 | | |
| NJAC | Cortland St (D3) | 24 | @ | New Jersey (D3) | 18 | | |
| MW | #9 Utah | 13 | @ | New Mexico | 10 | | |
| WAC | #9 Boise St | 49 | @ | New Mexico St | 0 | | |
| SAC | Lenoir-Rhyne (D2) | 14 | @ | Newberry (D2) | 38 | | |
| SLC | Central Arkansas | 17 | @ | Nicholls St | 20 | | |
| GSC | Arkansas-Monticello (D2) | 14 | @ | North Alabama (D2) | 45 | | |
| Edward Waters (NAIA) | 14 | @ | North Carolina Central | 34 | | |
| USASC | Christopher Newport (D3) | 27 | @ | North Carolina Wesleyan (D3) | 26 | | |
| CCIW | Illinois Wesleyan (D3) | 7 | @ | North Central (D3) | 30 | | |
| Indiana St | 7 | @ | North Dakota St | 34 | | |
| South Dakota | 63 | @ | North Greenville (D2) | 7 | | |
| CAAF | Villanova | 20 | @ | Northeastern | 14 | | |
| GLIAC | Grand Valley St (D2) | 45 | @ | Northern Michigan (D2) | 14 | | |
| GLIAC | Wayne St MI (D2) | 42 | @ | Northwood (D2) | 21 | | |
| Pittsburgh | 36 | @ | Notre Dame | 33 | 4OT | |
| MAIAA | Emporia St (D2) | 7 | @ | NW Missouri St (D2) | 56 | | |
| CSFL | Southern Nazarene (NAIA) | 21 | @ | NW Oklahoma St (NAIA) | 42 | | |
| NCA | Hiram (D3) | 7 | @ | Ohio Wesleyan (D3) | 31 | | |
| B12 | Nebraska | 28 | @ | #6 Oklahoma | 62 | | |
| B12 | Iowa St | 17 | @ | #10 Oklahoma St | 59 | | |
| P10 | Arizona St | 25 | @ | Oregon St | 27 | | |
| KCAC | Bethel KS (NAIA) | 21 | @ | Ottawa (NAIA) | 31 | | |
| OAC | Marietta (D3) | 0 | @ | Otterbein (D3) | 55 | | |
| GSC | West Alabama (D2) | 43 | @ | Ouachita Baptist (D2) | 45 | | |
| NWC | Whitworth (D3) | 40 | @ | Pacific Lutheran (D3) | 29 | | |
| Ivy | Brown | 34 | @ | Pennsylvania | 27 | | |
| MSC | Georgetown KY (NAIA) | 59 | @ | Pikeville (NAIA) | 21 | | |
| MAIAA | Washburn (D2) | 17 | @ | Pittsburg St (D2) | 48 | | |
| SCIAC | Redlands (D3) | 52 | @ | Pomona-Pitzer (D3) | 14 | | |
| Liberty | 28 | @ | Presbyterian | 31 | | |
| NWC | Linfield (D3) | 32 | @ | Puget Sound (D3) | 24 | | |
| B10 | Michigan | 42 | @ | Purdue | 48 | | |
| MSFA | Trinity Int'l (NAIA) | 9 | @ | Quincy (NAIA) | 28 | | |
| ODC | Guilford (D3) | 24 | @ | Randolph-Macon (D3) | 55 | | |
| CAAF | Massachusetts | 49 | @ | Rhode Island | 0 | | |
| SCAC | Centre (D3) | 23 | @ | Rhodes (D3) | 15 | | |
| MidW | Grinnell (D3) | 7 | @ | Ripon (D3) | 50 | | |
| NE | Central Conn St | 14 | @ | Robert Morris | 27 | | |
| Alfred (D3) | 43 | @ | Rochester (D3) | 14 | | |
| Eastern Oregon (NAIA) | 21 | @ | Rocky Mountain (NAIA) | 37 | | |
| NJAC | Kean (D3) | 22 | @ | Rowan (D3) | 30 | | |
| LL | Union NY (D3) | 12 | @ | RPI (D3) | 25 | | |
| NE | Wagner | 30 | @ | Sacred Heart | 42 | | |
| ACF | Wesley (D3) | 36 | @ | Salisbury (D3) | 21 | | |
| SLC | Stephen F. Austin | 17 | @ | Sam Houston St | 24 | | |
| Furman | 28 | @ | Samford | 27 | | |
| Pio | Dayton | 30 | @ | San Diego | 22 | | |
| Concordia AL (NAIA) | 7 | @ | Savannah St | 23 | | |
| SLC | McNeese St | 24 | @ | SE Louisiana St | 14 | | |
| OVC | Eastern Kentucky | 29 | @ | SE Missouri St | 16 | | |
| USASC | Averett (D3) | 33 | @ | Shenandoah (D3) | 21 | | |
| PSAC | Cheyney (D2) | 7 | @ | Shippensburg (D2) | 62 | | |
| GPAC | Northwestern IA (NAIA) | 0 | @ | Sioux Falls (NAIA) | 19 | | |
| PSAC | Lock Haven (D2) | 7 | @ | Slippery Rock (D2) | 45 | | |
| SEC | Tennessee | 6 | @ | South Carolina | 27 | | |
| MVC | Missouri St | 13 | @ | South Dakota St | 43 | | |
| P10 | Washington | 0 | @ | #7 Southern Cal | 56 | | |
| NE10 | Assumption (D2) | 12 | @ | Southern Conn St (D2) | 28 | | |
| North Dakota (D2) | 21 | @ | Southern Illinois | 40 | | |
| CUSA | Alabama-Birmingham | 14 | @ | Southern Miss | 70 | | |
| SWAC | Arkansas-Pine Bluff | 24 | @ | Southern U. | 31 | OT | |
| NAIAInd | Kentucky Christian (NAIA) | 27 | @ | Southern Virginia (NAIA) | 30 | | |
| KCAC | Tabor (NAIA) | 32 | @ | Southwestern KS (NAIA) | 29 | | |
| MSFA | Iowa Wesleyan (NAIA) | 0 | @ | St Ambrose (NAIA) | 49 | | |
| NE10 | Stonehill (D2) | 35 | @ | St Anselm (D2) | 0 | | |
| Chowan (D2) | 31 | @ | St Augustine's (D2) | 33 | | |
| Minn St-Moorhead (D3) | 7 | @ | St Cloud St (D2) | 42 | | |
| MSFA | McKendree (NAIA) | 14 | @ | St Francis IL (NAIA) | 13 | | |
| TPAC | Thiel (D3) | 36 | @ | St Vincent (D3) | 22 | | |
| P10 | Washington St | 0 | @ | Stanford | 58 | | |
| Morehouse (D2) | 17 | @ | Stillman (D2) | 16 | | |
| Gardner-Webb | 34 | @ | Stony Brook | 33 | | |
| ASWC | Louisiana College (D3) | 28 | @ | Sul Ross St (D3) | 14 | | |
| Becker (D3) | 26 | @ | SUNY-Maritime (D3) | 36 | | |
| St Lawrence (D3) | 49 | @ | Susquehanna (D3) | 42 | | |
| St Joseph's IN (D2) | 7 | @ | SW Baptist (D2) | 38 | | |
| NSIC | Northern St SD (D2) | 32 | @ | SW Minnesota St (D2) | 39 | | |
| OK Panhandle St (D2) | 7 | @ | SW Oklahoma St (D2) | 42 | | |
| BigE | Louisville | 21 | @ | Syracuse | 28 | | |
| LSC | SE Oklahoma St (D2) | 28 | @ | TAMU-Commerce (D2) | 24 | | |
| LSC | Abilene Christian (D2) | 42 | @ | TAMU-Kingsville (D2) | 17 | | |
| MSFA | Marian (NAIA) | 32 | @ | Taylor (NAIA) | 23 | | |
| OVC | Tennessee Tech | 14 | @ | Tennessee St | 41 | | |
| B12 | Colorado | 17 | @ | Texas A&M | 24 | | |
| CSFL | Bacone (NAIA) | 20 | @ | Texas College (NAIA) | 14 | | |
| ASWC | Hardin-Simmons (D3) | 52 | @ | Texas Lutheran (D3) | 6 | | |
| SLC | Northwestern St | 34 | @ | Texas St-San Marcos | 31 | OT | |
| B12 | #3 Texas | 33 | @ | #4 Texas Tech | 39 | | |
| SoCon | Georgia Southern | 44 | @ | The Citadel | 41 | 3OT | |
| Wash & Jeff (D3) | 29 | @ | Thomas More (D3) | 35 | | |
| CAAF | William & Mary | 34 | @ | Towson | 13 | | |
| MIAA | Albion (D3) | 7 | @ | Trine (D3) | 30 | | |
| NESCAA | Amherst (D3) | 13 | @ | Trinity CT (D3) | 30 | | |
| SCAC | Millsaps (D3) | 56 | @ | Trinity TX (D3) | 27 | | |
| MAIAA | Missouri Southern (D2) | 7 | @ | Truman St (D2) | 38 | | |
| NESCAA | Colby (D3) | 10 | @ | Tufts (D3) | 17 | | |
| Concord (D2) | 0 | @ | UNC-Pembroke (D2) | 57 | | |
| MW | #12 TCU | 44 | @ | UNLV | 14 | | |
| MSFA | St Francis IN (NAIA) | 62 | @ | Urbana (NAIA) | 20 | | |
| WAC | Hawaii | 14 | @ | Utah St | 30 | | |
| CUSA | Rice | 49 | @ | UTEP | 44 | | |
| E8 | St John Fisher (D3) | 17 | @ | Utica (D3) | 10 | | |
| WIAC | UW-River Falls (D3) | 0 | @ | UW-Platteville (D3) | 7 | | |
| WIAC | UW-Oshkosh (D3) | 33 | @ | UW-Stevens Point (D3) | 34 | | |
| WIAC | UW-La Crosse (D3) | 14 | @ | UW-Stout (D3) | 26 | | |
| WIAC | UW-Eau Claire (D3) | 10 | @ | UW-Whitewater (D3) | 40 | | |
| DAC | South Dakota Tech (NAIA) | 14 | @ | Valley City St (NAIA) | 34 | | |
| ACC | #23 Miami FL | 24 | @ | Virginia | 17 | OT | |
| MSC | Union KY (NAIA) | 37 | @ | Virginia-Wise (NAIA) | 34 | | |
| NCA | Oberlin (D3) | 7 | @ | Wabash (D3) | 60 | | |
| ACC | Duke | 30 | @ | Wake Forest | 33 | OT | |
| MSFA | Ohio Dominican (NAIA) | 24 | @ | Walsh (NAIA) | 22 | | |
| IIAC | Luther (D3) | 0 | @ | Wartburg (D3) | 14 | | |
| UAA | Carnegie Mellon (D3) | 8 | @ | Washington U. (D3) | 16 | | |
| NSIC | Concordia-St Paul (D2) | 17 | @ | Wayne St NE (D2) | 41 | | |
| TPAC | Grove City (D3) | 23 | @ | Waynesburg (D3) | 19 | | |
| BSky | Portland St | 21 | @ | Weber St | 31 | | |
| WVIAC | Charleston WV (D2) | 24 | @ | West Liberty St (D2) | 26 | | |
| LSC | Northeastern St OK (D2) | 9 | @ | West Texas A&M (D2) | 59 | | |
| WVIAC | Shepherd (D2) | 56 | @ | West Virginia St (D2) | 14 | | |
| SoCon | Chattanooga | 7 | @ | Western Carolina | 27 | | |
| NJAC | Montclair St (D3) | 38 | @ | Western Conn St (D3) | 14 | | |
| MVC | Northern Iowa | 30 | @ | Western Illinois | 6 | | |
| North Texas | 51 | @ | Western Kentucky | 40 | | |
| MAC | Eastern Michigan | 10 | @ | Western Michigan | 31 | | |
| NEF | Salve Regina (D3) | 28 | @ | Western New England (D3) | 14 | | |
| RMAC | Colorado St-Pueblo (D2) | 14 | @ | Western New Mexico (D2) | 24 | | |
| D2Ind | Humboldt St (D2) | 10 | @ | Western Oregon (D2) | 34 | | |
| RMAC | Adams St (D2) | 16 | @ | Western St CO (D2) | 10 | | |
| Greenville (D3) | 29 | @ | Westminster MO (D3) | 27 | | |
| SCIAC | La Verne (D3) | 24 | @ | Whittier (D3) | 21 | | |
| MidAC | King's PA (D3) | 3 | @ | Wilkes (D3) | 21 | | |
| Buffalo St (D3) | 24 | @ | William Paterson (D3) | 51 | | |
| MSFA | Olivet Nazarene (NAIA) | 24 | @ | William Penn (NAIA) | 42 | | |
| NESCAA | Wesleyan (D3) | 14 | @ | Williams (D3) | 48 | | |
| Augustana SD (D2) | 24 | @ | Winona St (D2) | 41 | | |
| NCA | Denison (D3) | 0 | @ | Wittenberg (D3) | 23 | | |
| NCA | Allegheny (D3) | 21 | @ | Wooster (D3) | 35 | | |
| NEF | Bridgewater St MA (D3) | 47 | @ | Worcester St (D3) | 14 | | |
| WVIAC | Glenville St (D2) | 40 | @ | WV Wesleyan (D2) | 14 | | |
| MW | San Diego St | 10 | @ | Wyoming | 35 | | |
| Ivy | Columbia | 12 | @ | Yale | 27 | | |
| Sunday, 2 Nov 2008 |
| CUSA | East Carolina | 13 | @ | Central Florida | 10 | OT | |
| Tuesday, 4 Nov 2008 |
| MAC | Miami OH | 17 | @ | Buffalo | 37 | | |
| Wednesday, 5 Nov 2008 |
| MAC | Toledo | 30 | @ | Akron | 47 | | |
| MAC | Northern Illinois | 14 | @ | #16 Ball St | 45 | | |