| 8/28/2008 | Southwest Baptist D2 | 28 | @ | SE Missouri St | 35 | OT | |||
| 9/6/2008 | SE Missouri St | 3 | @ | Missouri | 52 | ||||
| 9/11/2008 | Tennessee Tech | 29 | @ | SE Missouri St | 27 | OVC | |||
| 9/27/2008 | SE Missouri St | 24 | @ | Indiana St | 21 | ||||
| 10/4/2008 | SE Missouri St | 17 | @ | Jacksonville St | 38 | OVC | |||
| 10/18/2008 | SE Missouri St | 21 | @ | Eastern Illinois | 24 | OVC | |||
| 10/25/2008 | Tennessee St | 20 | @ | SE Missouri St | 27 | OVC | |||
| 11/1/2008 | Eastern Kentucky | 29 | @ | SE Missouri St | 16 | OVC | |||
| 11/8/2008 | SE Missouri St | 10 | @ | Murray St | 17 | OVC | |||
| 11/15/2008 | Tennessee-Martin | 31 | @ | SE Missouri St | 21 | OVC | |||
| 11/22/2008 | SE Missouri St | 33 | @ | Austin Peay | 30 | OVC |