| Thursday, 16 Oct 2008 |
| GSC | North Alabama (D2) | 28 | @ | Delta St (D2) | 34 | | |
| RMAC | Western St CO (D2) | 19 | @ | Mesa St (D2) | 29 | | |
| ACC | Florida St | 26 | @ | North Carolina St | 17 | | |
| NSIC | Mary (D2) | 34 | @ | Northern St SD (D2) | 31 | | |
| MW | Brigham Young | 7 | @ | #12 TCU | 32 | | |
| OVC | Tennessee-Martin | 35 | @ | Tennessee Tech | 7 | | |
| Friday, 17 Oct 2008 |
| WAC | Hawaii | 7 | @ | #11 Boise St | 27 | | |
| Saturday, 18 Oct 2008 |
| SEC | Mississippi | 20 | @ | #3 Alabama | 24 | | |
| SWAC | Alcorn St | 13 | @ | Alabama A&M | 20 | | |
| CUSA | Marshall | 21 | @ | Alabama-Birmingham | 23 | | |
| MIAA | Adrian (D3) | 28 | @ | Albion (D3) | 6 | | |
| MidAC | King's PA (D3) | 9 | @ | Albright (D3) | 15 | | |
| MIAA | Kalamazoo (D3) | 24 | @ | Alma (D3) | 56 | | |
| NE10 | Pace (D2) | 20 | @ | American Int'l (D2) | 42 | | |
| HCA | Franklin (D3) | 56 | @ | Anderson (D3) | 27 | | |
| LSC | SE Oklahoma St (D2) | 35 | @ | Angelo St (D2) | 0 | | |
| P10 | California | 27 | @ | Arizona | 42 | | |
| GSC | West Alabama (D2) | 14 | @ | Arkansas-Monticello (D2) | 27 | | |
| SWAC | Prairie View A&M | 15 | @ | Arkansas-Pine Bluff | 0 | | |
| GLIAC | Saginaw Valley St (D2) | 28 | @ | Ashland (D2) | 31 | | |
| MIA | Concordia-Moorhead (D3) | 40 | @ | Augsburg (D3) | 18 | | |
| IBC | Concordia WI (D3) | 19 | @ | Aurora (D3) | 21 | | |
| HAAC | Central Methodist (NAIA) | 23 | @ | Avila (NAIA) | 7 | | |
| HAAC | Evangel (NAIA) | 9 | @ | Baker (NAIA) | 45 | | |
| MidW | Illinois College (D3) | 58 | @ | Beloit (D3) | 42 | | |
| NSIC | Minnesota-Crookston (D2) | 27 | @ | Bemidji St (D2) | 41 | | |
| Maranatha Baptist (D3) | 0 | @ | Benedictine IL (D3) | 44 | | |
| Peru St (NAIA) | 13 | @ | Benedictine KS (NAIA) | 36 | | |
| NE10 | Merrimack (D2) | 27 | @ | Bentley (D2) | 11 | | |
| Southern Nazarene (NAIA) | 24 | @ | Bethel KS (NAIA) | 25 | | |
| West Virginia Tech (D2) | 19 | @ | Bethel TN (NAIA) | 56 | | |
| Austin (D3) | 48 | @ | Birmingham-Southern (D3) | 29 | | |
| HCA | Manchester (D3) | 17 | @ | Bluffton (D3) | 7 | | |
| ACC | Virginia Tech | 23 | @ | Boston College | 28 | | |
| NESCAA | Trinity CT (D3) | 40 | @ | Bowdoin (D3) | 16 | | |
| MAC | Miami OH | 27 | @ | Bowling Green | 20 | | |
| GPAC | Dakota Wesleyan (NAIA) | 41 | @ | Briar Cliff (NAIA) | 7 | | |
| Coast Guard (D3) | 7 | @ | Bridgewater St MA (D3) | 38 | | |
| Robert Morris | 7 | @ | Bryant (D2) | 20 | | |
| IIAC | Luther (D3) | 6 | @ | Buena Vista (D3) | 3 | | |
| Army | 24 | @ | Buffalo | 27 | OT | |
| Millersville (D2) | 38 | @ | C.W. Post (D2) | 55 | | |
| MSC | Belhaven (NAIA) | 33 | @ | Campbellsville (NAIA) | 35 | | |
| MIA | Gustavus Adolphus (D3) | 30 | @ | Carleton (D3) | 29 | | |
| SAC | Lenoir-Rhyne (D2) | 21 | @ | Carson-Newman (D2) | 62 | | |
| SAC | Tusculum (D2) | 35 | @ | Catawba (D2) | 37 | | |
| NE | Duquesne | 23 | @ | Central Conn St | 35 | | |
| MAC | Western Michigan | 28 | @ | Central Michigan | 38 | | |
| Occidental (D3) | 31 | @ | Chapman (D3) | 28 | | |
| Seton Hill (NAIA) | 21 | @ | Charleston WV (D2) | 44 | | |
| SoCon | Elon | 42 | @ | Chattanooga | 7 | | |
| PSAC | Bloomsburg (D2) | 43 | @ | Cheyney (D2) | 7 | | |
| Macalester (D3) | 6 | @ | Chicago (D3) | 24 | | |
| SCIAC | Cal Lutheran (D3) | 23 | @ | Claremont-Mudd-Scripps (D3) | 14 | | |
| SIAC | Morehouse (D2) | 2 | @ | Clark Atlanta (D2) | 29 | | |
| ACC | #18 Georgia Tech | 21 | @ | Clemson | 17 | | |
| North Carolina Central | 10 | @ | Coastal Carolina | 35 | | |
| IIAC | Central IA (D3) | 27 | @ | Coe (D3) | 10 | | |
| NESCAA | Hamilton (D3) | 13 | @ | Colby (D3) | 16 | | |
| B12 | Kansas St | 13 | @ | Colorado | 14 | | |
| RMAC | Adams St (D2) | 0 | @ | Colorado Mines (D2) | 23 | | |
| RMAC | New Mexico Highlands (D2) | 14 | @ | Colorado St-Pueblo (D2) | 21 | | |
| WVIAC | Glenville St (D2) | 34 | @ | Concord (D2) | 14 | | |
| IBC | Lakeland (D3) | 32 | @ | Concordia IL (D3) | 35 | | |
| GPAC | Morningside (NAIA) | 49 | @ | Concordia NE (NAIA) | 0 | | |
| NSIC | SW Minnesota St (D2) | 38 | @ | Concordia-St Paul (D2) | 28 | | |
| Colgate | 38 | @ | Cornell NY | 22 | | |
| HAAC | William Jewell (NAIA) | 23 | @ | Culver-Stockton (NAIA) | 16 | | |
| MSC | Virginia-Wise (NAIA) | 27 | @ | Cumberland TN (NAIA) | 14 | | |
| MSC | Georgetown KY (NAIA) | 20 | @ | Cumberlands KY (NAIA) | 35 | | |
| Waldorf (NAIA) | 14 | @ | Dana (NAIA) | 42 | | |
| Holy Cross | 44 | @ | Dartmouth | 26 | | |
| Pio | Dayton | 41 | @ | Davidson | 22 | | |
| Rose-Hulman (D3) | 28 | @ | Defiance (D3) | 21 | | |
| CAAF | William & Mary | 27 | @ | Delaware | 3 | | |
| MEAC | North Carolina A&T | 7 | @ | Delaware St | 42 | | |
| NCA | Allegheny (D3) | 10 | @ | Denison (D3) | 13 | | |
| DAC | Black Hills St (NAIA) | 6 | @ | Dickinson St (NAIA) | 16 | | |
| GPAC | Northwestern IA (NAIA) | 43 | @ | Doane (NAIA) | 9 | | |
| Pio | Campbell | 0 | @ | Drake | 45 | | |
| IIAC | Cornell IA (D3) | 10 | @ | Dubuque (D3) | 31 | | |
| ACC | Miami FL | 49 | @ | Duke | 31 | | |
| NCA | Hiram (D3) | 41 | @ | Earlham (D3) | 49 | | |
| CUSA | Memphis | 10 | @ | East Carolina | 30 | | |
| PSAC | Kutztown (D2) | 3 | @ | East Stroudsburg (D2) | 27 | | |
| ASWC | Louisiana College (D3) | 27 | @ | East Texas Baptist (D3) | 20 | | |
| OVC | SE Missouri St | 21 | @ | Eastern Illinois | 24 | | |
| MAC | Akron | 42 | @ | Eastern Michigan | 35 | | |
| Montana St-Northern (NAIA) | 14 | @ | Eastern Oregon (NAIA) | 42 | | |
| CCIW | North Park (D3) | 21 | @ | Elmhurst (D3) | 42 | | |
| ODC | Randolph-Macon (D3) | 10 | @ | Emory & Henry (D3) | 24 | | |
| NEF | Curry (D3) | 46 | @ | Endicott (D3) | 27 | | |
| CIAA | Johnson C. Smith (D2) | 3 | @ | Fayetteville St (D2) | 48 | | |
| MidAC | Delaware Valley (D3) | 14 | @ | FDU-Florham (D3) | 19 | | |
| GLIAC | Wayne St MI (D2) | 19 | @ | Ferris St (D2) | 0 | | |
| GLIAC | Grand Valley St (D2) | 34 | @ | Findlay (D2) | 10 | | |
| NEF | Worcester St (D3) | 28 | @ | Fitchburg St (D3) | 42 | | |
| Yale | 10 | @ | Fordham | 12 | | |
| RMAC | Chadron St (D2) | 48 | @ | Fort Lewis (D2) | 7 | | |
| SIAC | Benedict (D2) | 6 | @ | Fort Valley St (D2) | 22 | | |
| SoCon | The Citadel | 20 | @ | Furman | 34 | | |
| Southern Virginia (NAIA) | 44 | @ | Gallaudet (D3) | 9 | | |
| California PA (D2) | 42 | @ | Gannon (D2) | 24 | | |
| Presbyterian | 21 | @ | Gardner-Webb | 47 | | |
| Waynesburg (D3) | 34 | @ | Geneva (NAIA) | 28 | | |
| Pat | Bucknell | 27 | @ | Georgetown DC | 24 | | |
| SEC | Vanderbilt | 14 | @ | #9 Georgia | 24 | | |
| SoCon | Appalachian St | 37 | @ | Georgia Southern | 36 | | |
| SWAC | Alabama St | 7 | @ | Grambling St | 27 | | |
| USASC | Shenandoah (D3) | 35 | @ | Greensboro (D3) | 14 | | |
| Thomas More (D3) | 35 | @ | Grove City (D3) | 14 | | |
| ODC | Bridgewater VA (D3) | 27 | @ | Guilford (D3) | 20 | | |
| MIA | Bethel MN (D3) | 9 | @ | Hamline (D3) | 7 | | |
| MEAC | Norfolk St | 17 | @ | Hampton | 35 | | |
| HCA | Mt St Joseph (D3) | 37 | @ | Hanover (D3) | 19 | | |
| Becker (D3) | 12 | @ | Hartwick (D3) | 49 | | |
| Lehigh | 24 | @ | Harvard | 27 | | |
| McPherson (NAIA) | 43 | @ | Haskell (NAIA) | 14 | | |
| GPAC | Nebraska Wesleyan (NAIA) | 7 | @ | Hastings (NAIA) | 3 | | |
| GLIAC | Northern Michigan (D2) | 25 | @ | Hillsdale (D2) | 49 | | |
| MEAC | Morgan St | 31 | @ | Howard | 30 | | |
| ASWC | Hardin-Simmons (D3) | 60 | @ | Howard Payne (D3) | 13 | | |
| Central Washington (D2) | 34 | @ | Humboldt St (D2) | 14 | | |
| Blackburn (D3) | 0 | @ | Huntingdon (D3) | 45 | | |
| BSky | Northern Arizona | 52 | @ | Idaho St | 30 | | |
| B10 | Indiana | 13 | @ | Illinois | 56 | | |
| MVC | Missouri St | 34 | @ | Illinois St | 28 | | |
| CCIW | Augustana IL (D3) | 21 | @ | Illinois Wesleyan (D3) | 13 | | |
| Mercyhurst (D2) | 10 | @ | Indiana PA (D2) | 42 | | |
| B10 | Wisconsin | 16 | @ | Iowa | 38 | | |
| B12 | Nebraska | 35 | @ | Iowa St | 7 | | |
| MSFA | Quincy (NAIA) | 35 | @ | Iowa Wesleyan (NAIA) | 28 | | |
| Frostburg St (D3) | 24 | @ | Ithaca (D3) | 51 | | |
| OVC | Murray St | 21 | @ | Jacksonville St | 31 | | |
| DAC | Mayville St (NAIA) | 0 | @ | Jamestown (NAIA) | 51 | | |
| OAC | Capital (D3) | 3 | @ | John Carroll (D3) | 13 | | |
| Gettysburg (D3) | 24 | @ | Juniata (D3) | 20 | | |
| KCAC | Friends (NAIA) | 42 | @ | Kansas Wesleyan (NAIA) | 30 | | |
| Brockport St (D3) | 36 | @ | Kean (D3) | 34 | | |
| SEC | Arkansas | 20 | @ | Kentucky | 21 | | |
| Trinity Bible (NAIA) | 6 | vs | Kentucky Christian (NAIA) | 50 | | South Point OH |
| NCA | Oberlin (D3) | 31 | @ | Kenyon (D3) | 28 | | |
| MidW | Lawrence (D3) | 25 | @ | Knox (D3) | 28 | | |
| SCIAC | Pomona-Pitzer (D3) | 37 | @ | La Verne (D3) | 45 | | |
| Westminster MO (D3) | 20 | @ | LaGrange (D3) | 37 | | |
| MidW | Grinnell (D3) | 16 | @ | Lake Forest (D3) | 24 | | |
| Faulkner (NAIA) | 31 | @ | Lambuth (NAIA) | 66 | | |
| MidAC | Widener (D3) | 13 | @ | Lebanon Valley (D3) | 20 | | |
| NWC | Linfield (D3) | 55 | @ | Lewis & Clark (D3) | 7 | | |
| Lafayette | 35 | @ | Liberty | 21 | | |
| GLFC | Central St OH (D2) | 36 | @ | Lincoln MO (D2) | 17 | | |
| CIAA | Elizabeth City St (D2) | 70 | @ | Lincoln PA (D2) | 6 | | |
| HAAC | Graceland (NAIA) | 3 | @ | Lindenwood (NAIA) | 49 | | |
| CIAA | St Augustine's (D2) | 28 | @ | Livingstone (D2) | 6 | | |
| PSAC | Clarion (D2) | 24 | @ | Lock Haven (D2) | 21 | | |
| WAC | Idaho | 14 | @ | Louisiana Tech | 46 | | |
| SBC | Arkansas St | 23 | @ | Louisiana-Lafayette | 28 | | |
| SBC | North Texas | 23 | @ | Louisiana-Monroe | 35 | | |
| Middle Tennessee St | 23 | @ | Louisville | 42 | | |
| IBC | Greenville (D3) | 45 | @ | MacMurray (D3) | 29 | | |
| CAAF | Hofstra | 40 | @ | Maine | 41 | | |
| NEF | Mass Maritime (D3) | 7 | @ | Maine Maritime (D3) | 26 | | |
| Grand View (NAIA) | 21 | @ | Marian (NAIA) | 38 | | |
| Brevard (D2) | 14 | @ | Mars Hill (D2) | 28 | | |
| UMWAC | Crown (NAIA) | 41 | @ | Martin Luther (NAIA) | 35 | | |
| ASWC | Mississippi College (D3) | 14 | @ | Mary Hardin-Baylor (D3) | 26 | | |
| ACC | Wake Forest | 0 | @ | Maryland | 26 | | |
| Christopher Newport (D3) | 38 | @ | Maryville (D3) | 31 | | |
| CAAF | Richmond | 30 | @ | Massachusetts | 15 | | |
| Cen | Muhlenberg (D3) | 49 | @ | McDaniel (D3) | 6 | | |
| USASC | Ferrum (D3) | 31 | @ | Methodist (D3) | 13 | | |
| B10 | #8 Ohio State | 45 | @ | #20 Michigan St | 7 | | |
| GLIAC | Indianapolis (D2) | 28 | @ | Michigan Tech (D2) | 31 | | |
| HAAC | Missouri Valley (NAIA) | 25 | @ | MidAmerica Nazarene (NAIA) | 43 | | |
| NESCAA | Bates (D3) | 14 | @ | Middlebury (D3) | 38 | | |
| GPAC | Dordt (NAIA) | 0 | @ | Midland Lutheran (NAIA) | 27 | | |
| SIAC | Kentucky St (D2) | 23 | @ | Miles (D2) | 29 | | |
| SCAC | Sewanee (D3) | 17 | @ | Millsaps (D3) | 38 | | |
| Minn St-Mankato (D2) | 0 | @ | Minn St-Moorhead (D3) | 52 | | |
| DAC | South Dakota Tech (NAIA) | 16 | @ | Minot St (NAIA) | 25 | | |
| Savannah St | 20 | @ | Mississippi Valley St | 22 | | |
| GLFC | Kentucky Wesleyan (D2) | 7 | @ | Missouri S&T (D2) | 58 | | |
| MAIAA | Central Missouri (D2) | 47 | @ | Missouri Southern (D2) | 14 | | |
| MAIAA | Emporia St (D2) | 21 | @ | Missouri Western (D2) | 28 | | |
| NEF | Western New England (D3) | 15 | @ | MIT (D3) | 48 | | |
| MidW | Ripon (D3) | 35 | @ | Monmouth IL (D3) | 38 | | |
| BSky | Sacramento St | 7 | @ | Montana | 43 | | |
| BSky | Eastern Washington | 34 | @ | Montana St | 17 | | |
| Front | Montana Tech (NAIA) | 24 | @ | Montana-Western (NAIA) | 17 | | |
| Buffalo St (D3) | 28 | @ | Montclair St (D3) | 45 | | |
| Franklin & Marshall (D3) | 20 | @ | Moravian (D3) | 23 | | |
| Pio | Jacksonville FL | 40 | @ | Morehead St | 9 | | |
| OAC | Heidelberg (D3) | 0 | @ | Mount Union (D3) | 49 | | |
| OAC | Baldwin-Wallace (D3) | 42 | @ | Muskingum (D3) | 7 | | |
| #19 Pittsburgh | 42 | @ | Navy | 21 | | |
| WAC | Utah St | 17 | @ | Nevada | 44 | | |
| NJAC | William Paterson (D3) | 7 | @ | New Jersey (D3) | 24 | | |
| MW | San Diego St | 7 | @ | New Mexico | 70 | | |
| WAC | San Jose St | 31 | @ | New Mexico St | 14 | | |
| SAC | Wingate (D2) | 21 | @ | Newberry (D2) | 32 | | |
| SLC | Stephen F. Austin | 50 | @ | Nicholls St | 39 | | |
| Plymouth St (D3) | 36 | @ | Nichols (D3) | 9 | | |
| USASC | Averett (D3) | 24 | @ | North Carolina Wesleyan (D3) | 49 | | |
| CCIW | Carthage (D3) | 24 | @ | North Central (D3) | 31 | | |
| NCC | Western Washington (D2) | 32 | @ | North Dakota (D2) | 42 | | |
| CAAF | New Hampshire | 33 | @ | Northeastern | 21 | | |
| SW Baptist (D2) | 20 | @ | Northeastern St OK (D2) | 45 | | |
| MAC | Toledo | 7 | @ | Northern Illinois | 38 | | |
| North Dakota St | 13 | @ | Northern Iowa | 23 | | |
| B10 | Purdue | 26 | @ | #23 Northwestern | 48 | | |
| E8 | St John Fisher (D3) | 45 | @ | Norwich (D3) | 6 | | |
| Fort Hays St (D2) | 7 | @ | NW Missouri St (D2) | 56 | | |
| OK Panhandle St (D2) | 19 | @ | NW Oklahoma St (NAIA) | 45 | | |
| OAC | Marietta (D3) | 0 | @ | Ohio Northern (D3) | 28 | | |
| Case Western Reserve (D3) | 35 | @ | Ohio Wesleyan (D3) | 7 | | |
| B12 | Kansas | 31 | @ | #4 Oklahoma | 45 | | |
| B12 | Baylor | 6 | @ | #6 Oklahoma St | 34 | | |
| MSFA | Trinity Int'l (NAIA) | 14 | @ | Olivet Nazarene (NAIA) | 44 | | |
| KCAC | Bethany KS (NAIA) | 14 | @ | Ottawa (NAIA) | 49 | | |
| OAC | Wilmington (D3) | 14 | @ | Otterbein (D3) | 30 | | |
| GSC | Southern Arkansas (D2) | 14 | @ | Ouachita Baptist (D2) | 30 | | |
| NWC | Willamette (D3) | 45 | @ | Pacific Lutheran (D3) | 18 | | |
| B10 | Michigan | 17 | @ | #4 Penn State | 46 | | |
| Ivy | Columbia | 10 | @ | Pennsylvania | 15 | | |
| Nebraska-Omaha (D2) | 28 | @ | Pittsburg St (D2) | 35 | | |
| Ivy | Brown | 31 | @ | Princeton | 10 | | |
| Eureka (D3) | 47 | @ | Principia (D3) | 19 | | |
| CAAF | Villanova | 44 | @ | Rhode Island | 7 | | |
| Colorado College (D3) | 7 | @ | Rhodes (D3) | 28 | | |
| CUSA | Southern Miss | 40 | @ | Rice | 45 | | |
| LL | Merchant Marine (D3) | 14 | @ | Rochester (D3) | 30 | | |
| Front | Carroll MT (NAIA) | 59 | @ | Rocky Mountain (NAIA) | 13 | | |
| Morrisville St (D3) | 14 | @ | Rowan (D3) | 58 | | |
| Susquehanna (D3) | 14 | @ | RPI (D3) | 35 | | |
| BigE | Connecticut | 10 | @ | Rutgers | 12 | | |
| NE | Albany NY | 26 | @ | Sacred Heart | 21 | | |
| Lake Erie (D2) | 15 | @ | Salisbury (D3) | 39 | | |
| SLC | McNeese St | 28 | @ | Sam Houston St | 17 | | |
| SLC | Northwestern St | 21 | @ | SE Louisiana St | 26 | | |
| Chowan (D2) | 13 | @ | Shaw (D2) | 68 | | |
| WVIAC | WV Wesleyan (D2) | 12 | @ | Shepherd (D2) | 27 | | |
| North Greenville (D2) | 21 | @ | Shorter (NAIA) | 37 | | |
| PSAC | Edinboro (D2) | 35 | @ | Slippery Rock (D2) | 14 | | |
| CUSA | Houston | 44 | @ | SMU | 38 | | |
| SEC | #21 LSU | 24 | @ | South Carolina | 17 | | |
| Cal Poly SLO | 42 | @ | South Dakota St | 28 | | |
| BigE | Syracuse | 13 | @ | #22 South Florida | 45 | | |
| NE10 | St Anselm (D2) | 0 | @ | Southern Conn St (D2) | 56 | | |
| NAIAInd | Azusa Pacific (NAIA) | 14 | @ | Southern Oregon (NAIA) | 16 | | |
| Florida A&M | 52 | @ | Southern U. | 49 | | |
| Mount Ida (D3) | 23 | @ | Springfield (D3) | 43 | | |
| MSFA | McKendree (NAIA) | 21 | @ | St Ambrose (NAIA) | 7 | | |
| NCC | Minnesota-Duluth (D2) | 38 | @ | St Cloud St (D2) | 21 | | |
| NE | Wagner | 17 | @ | St Francis PA | 13 | | |
| Fairmont St (D2) | 14 | @ | St Joseph's IN (D2) | 38 | | |
| MidW | Carroll WI (D3) | 17 | @ | St Norbert (D3) | 20 | | |
| CIAA | Bowie St (D2) | 21 | @ | St Paul's (D2) | 7 | | |
| UMWAC | Northwestern MN (NAIA) | 35 | @ | St Scholastica (D3) | 14 | | |
| MIA | St John's MN (D3) | 12 | @ | St Thomas (D3) | 9 | | |
| KCAC | Southwestern KS (NAIA) | 14 | @ | Sterling (NAIA) | 42 | | |
| Lane (D2) | 20 | @ | Stillman (D2) | 18 | | |
| NE10 | Assumption (D2) | 7 | @ | Stonehill (D2) | 31 | | |
| Charleston Southern | 19 | @ | Stony Brook | 20 | | |
| ASWC | McMurry (D3) | 17 | @ | Sul Ross St (D3) | 21 | | |
| D3Ind | Husson (D3) | 49 | @ | SUNY-Maritime (D3) | 14 | | |
| CSFL | Bacone (NAIA) | 27 | @ | SW Assem of God (NAIA) | 28 | | |
| LSC | Central Oklahoma (D2) | 23 | @ | SW Oklahoma St (D2) | 16 | | |
| KCAC | St Mary KS (NAIA) | 53 | @ | Tabor (NAIA) | 31 | | |
| LSC | East Central OK (D2) | 15 | @ | TAMU-Commerce (D2) | 27 | | |
| LSC | Midwestern St (D2) | 38 | @ | TAMU-Kingsville (D2) | 16 | | |
| LSC | Eastern New Mexico (D2) | 21 | @ | Tarleton St (D2) | 42 | | |
| SEC | Mississippi St | 3 | @ | Tennessee | 34 | | |
| OVC | Austin Peay | 34 | @ | Tennessee St | 37 | | |
| B12 | #14 Missouri | 31 | @ | #1 Texas | 56 | | |
| B12 | #11 Texas Tech | 43 | @ | Texas A&M | 25 | | |
| Langston (D2) | 25 | @ | Texas College (NAIA) | 11 | | |
| SWAC | Jackson St | 30 | @ | Texas Southern | 14 | | |
| SLC | Central Arkansas | 31 | @ | Texas St-San Marcos | 24 | | |
| Northwood (D2) | 31 | @ | Tiffin (D2) | 28 | | |
| MIAA | Olivet (D3) | 10 | @ | Trine (D3) | 21 | | |
| SCAC | DePauw (D3) | 32 | @ | Trinity TX (D3) | 45 | | |
| SBC | Florida Int'l | 23 | @ | Troy | 33 | | |
| MAIAA | Washburn (D2) | 31 | @ | Truman St (D2) | 17 | | |
| NESCAA | Williams (D3) | 7 | @ | Tufts (D3) | 17 | | |
| CUSA | UTEP | 35 | @ | #19 Tulsa | 77 | | |
| SIAC | Albany St GA (D2) | 20 | @ | Tuskegee (D2) | 33 | | |
| Iona | 24 | @ | UC-Davis | 55 | | |
| P10 | Stanford | 20 | @ | UCLA | 23 | | |
| NEF | Salve Regina (D3) | 33 | @ | UMass-Dartmouth (D3) | 41 | | |
| Edward Waters (NAIA) | 8 | @ | UNC-Pembroke (D2) | 43 | | |
| MSC | Pikeville (NAIA) | 24 | @ | Union KY (NAIA) | 42 | | |
| LL | St Lawrence (D3) | 14 | @ | Union NY (D3) | 35 | | |
| MW | Air Force | 29 | @ | UNLV | 28 | | |
| Augustana SD (D2) | 40 | @ | Upper Iowa (D2) | 7 | | |
| MSFA | St Xavier (NAIA) | 35 | @ | Urbana (NAIA) | 7 | | |
| Cen | Johns Hopkins (D3) | 14 | @ | Ursinus (D3) | 0 | | |
| MW | Colorado St | 16 | @ | #11 Utah | 49 | | |
| E8 | Alfred (D3) | 27 | @ | Utica (D3) | 10 | | |
| WIAC | UW-River Falls (D3) | 27 | @ | UW-Eau Claire (D3) | 19 | | |
| WIAC | UW-Platteville (D3) | 6 | @ | UW-La Crosse (D3) | 37 | | |
| WIAC | UW-Whitewater (D3) | 44 | @ | UW-Oshkosh (D3) | 3 | | |
| WIAC | UW-Stevens Point (D3) | 19 | @ | UW-Stout (D3) | 9 | | |
| GSC | Harding (D2) | 13 | @ | Valdosta St (D2) | 21 | | |
| DAC | Dakota St (NAIA) | 10 | @ | Valley City St (NAIA) | 40 | | |
| Pio | Butler | 48 | @ | Valparaiso | 21 | | |
| ACC | North Carolina | 13 | @ | Virginia | 16 | OT | |
| CIAA | Virginia St (D2) | 14 | @ | Virginia Union (D2) | 7 | | |
| MSFA | Malone (NAIA) | 24 | @ | Walsh (NAIA) | 21 | | |
| IIAC | Loras (D3) | 7 | @ | Wartburg (D3) | 35 | | |
| TPAC | St Vincent (D3) | 20 | @ | Wash & Jeff (D3) | 72 | | |
| P10 | Oregon St | 34 | @ | Washington | 13 | | |
| ODC | Hampden-Sydney (D3) | 39 | @ | Washington and Lee (D3) | 29 | | |
| P10 | #5 Southern Cal | 69 | @ | Washington St | 0 | | |
| NSIC | Winona St (D2) | 18 | @ | Wayne St NE (D2) | 55 | | |
| NAIAInd | Concordia AL (NAIA) | 9 | @ | Webber Int'l (NAIA) | 14 | | |
| BSky | Northern Colorado | 10 | @ | Weber St | 17 | | |
| ACF | Apprentice (D3) | 0 | @ | Wesley (D3) | 48 | | |
| NESCAA | Amherst (D3) | 17 | @ | Wesleyan (D3) | 10 | | |
| PSAC | Shippensburg (D2) | 7 | @ | West Chester (D2) | 25 | | |
| GSC | Arkansas Tech (D2) | 49 | @ | West Georgia (D2) | 24 | | |
| LSC | Abilene Christian (D2) | 52 | @ | West Texas A&M (D2) | 35 | | |
| WVIAC | West Liberty St (D2) | 24 | @ | West Virginia St (D2) | 34 | | |
| NJAC | Cortland St (D3) | 41 | @ | Western Conn St (D3) | 14 | | |
| MVC | Indiana St | 0 | @ | Western Illinois | 56 | | |
| Florida Atlantic | 24 | @ | Western Kentucky | 20 | | |
| RMAC | Nebraska-Kearney (D2) | 55 | @ | Western New Mexico (D2) | 34 | | |
| D2Ind | Dixie St (D2) | 35 | @ | Western Oregon (D2) | 42 | | |
| NEF | Framingham St (D3) | 0 | @ | Westfield St (D3) | 27 | | |
| TPAC | Bethany WV (D3) | 43 | @ | Westminster PA (D3) | 46 | | |
| CCIW | Millikin (D3) | 15 | @ | Wheaton (D3) | 37 | | |
| SCIAC | Redlands (D3) | 53 | @ | Whittier (D3) | 14 | | |
| NWC | Puget Sound (D3) | 7 | @ | Whitworth (D3) | 35 | | |
| MidAC | Lycoming (D3) | 13 | @ | Wilkes (D3) | 27 | | |
| MSFA | St Francis IL (NAIA) | 27 | @ | William Penn (NAIA) | 33 | | |
| Rockford (D3) | 7 | @ | Wisconsin Lutheran (D3) | 18 | | |
| NCA | Wabash (D3) | 13 | @ | Wittenberg (D3) | 10 | | |
| SoCon | Western Carolina | 14 | @ | Wofford | 42 | | |
| Washington U. (D3) | 13 | @ | Wooster (D3) | 38 | | |
| MVC | Southern Illinois | 33 | @ | Youngstown St | 0 | | |
| Tuesday, 21 Oct 2008 |
| MAC | Ohio U. | 10 | @ | Temple | 14 | | |