| Thursday, 2 Oct 2008 |
| CUSA | Memphis | 33 | @ | Alabama-Birmingham | 30 | | |
| WVIAC | West Liberty St (D2) | 20 | @ | Fairmont St (D2) | 13 | | |
| BigE | Pittsburgh | 26 | @ | South Florida | 21 | | |
| Oregon St | 28 | @ | #9 Utah | 31 | | |
| GSC | Delta St (D2) | 27 | @ | Valdosta St (D2) | 24 | | |
| Friday, 3 Oct 2008 |
| NE10 | Assumption (D2) | 19 | @ | Bentley (D2) | 22 | | |
| Southern Virginia (NAIA) | 31 | @ | Guilford (D3) | 47 | | |
| Cincinnati | 33 | @ | Marshall | 10 | | |
| NJAC | Kean (D3) | 35 | @ | New Jersey (D3) | 27 | | |
| #22 Brigham Young | 34 | @ | Utah St | 14 | | |
| Saturday, 4 Oct 2008 |
| LSC | East Central OK (D2) | 7 | @ | Abilene Christian (D2) | 66 | | |
| MIAA | Kalamazoo (D3) | 17 | @ | Adrian (D3) | 42 | | |
| Navy | 33 | @ | Air Force | 27 | | |
| SEC | #24 Kentucky | 14 | @ | #3 Alabama | 17 | | |
| Tuskegee (D2) | 34 | @ | Alabama A&M | 24 | | |
| Stillman (D2) | 14 | @ | Albany St GA (D2) | 35 | | |
| MidAC | FDU-Florham (D3) | 17 | @ | Albright (D3) | 24 | | |
| E8 | Norwich (D3) | 0 | @ | Alfred (D3) | 42 | | |
| HCA | Hanover (D3) | 12 | @ | Anderson (D3) | 56 | | |
| LSC | Eastern New Mexico (D2) | 13 | @ | Angelo St (D2) | 25 | | |
| SoCon | The Citadel | 21 | @ | Appalachian St | 47 | | |
| ACF | Salisbury (D3) | 48 | @ | Apprentice (D3) | 17 | | |
| P10 | Washington | 14 | @ | Arizona | 48 | | |
| SEC | #16 Florida | 38 | @ | Arkansas | 7 | | |
| GSC | North Alabama (D2) | 45 | @ | Arkansas Tech (D2) | 24 | | |
| GLIAC | Wayne St MI (D2) | 14 | @ | Ashland (D2) | 41 | | |
| NCC | Minn St-Mankato (D2) | 38 | @ | Augustana SD (D2) | 41 | | |
| IBC | Benedictine IL (D3) | 7 | @ | Aurora (D3) | 31 | | |
| OVC | Murray St | 32 | @ | Austin Peay | 12 | | |
| USASC | Ferrum (D3) | 30 | @ | Averett (D3) | 9 | | |
| HAAC | William Jewell (NAIA) | 34 | @ | Avila (NAIA) | 14 | | |
| CSFL | Southern Nazarene (NAIA) | 30 | @ | Bacone (NAIA) | 31 | | |
| HAAC | Graceland (NAIA) | 3 | @ | Baker (NAIA) | 41 | | |
| OAC | Mount Union (D3) | 48 | @ | Baldwin-Wallace (D3) | 3 | | |
| NESCAA | Williams (D3) | 27 | @ | Bates (D3) | 14 | | |
| B12 | #3 Oklahoma | 49 | @ | Baylor | 17 | | |
| Gallaudet (D3) | 26 | @ | Becker (D3) | 18 | | |
| Faulkner (NAIA) | 24 | @ | Belhaven (NAIA) | 49 | | |
| Thomas More (D3) | 42 | @ | Bethany WV (D3) | 12 | | |
| KCAC | Bethany KS (NAIA) | 6 | @ | Bethel KS (NAIA) | 13 | | |
| MIA | St John's MN (D3) | 9 | @ | Bethel MN (D3) | 14 | | |
| SCAC | Trinity TX (D3) | 48 | @ | Birmingham-Southern (D3) | 20 | | |
| DAC | Dakota St (NAIA) | 14 | @ | Black Hills St (NAIA) | 37 | | |
| Eureka (D3) | 26 | @ | Blackburn (D3) | 13 | | |
| HCA | Mt St Joseph (D3) | 50 | @ | Bluffton (D3) | 7 | | |
| NESCAA | Tufts (D3) | 26 | @ | Bowdoin (D3) | 28 | | |
| CIAA | Lincoln PA (D2) | 2 | @ | Bowie St (D2) | 28 | | |
| MAC | Eastern Michigan | 24 | @ | Bowling Green | 21 | | |
| Wingate (D2) | 44 | @ | Brevard (D2) | 13 | | |
| NEF | Fitchburg St (D3) | 14 | @ | Bridgewater St MA (D3) | 38 | | |
| ODC | Hampden-Sydney (D3) | 37 | @ | Bridgewater VA (D3) | 34 | | |
| Rowan (D3) | 37 | @ | Brockport St (D3) | 20 | | |
| IIAC | Wartburg (D3) | 21 | @ | Buena Vista (D3) | 26 | | |
| Pio | Drake | 15 | @ | Butler | 21 | | |
| GWest | South Dakota | 22 | @ | Cal Poly SLO | 49 | | |
| P10 | Arizona St | 14 | @ | #21 California | 24 | | |
| MSC | Shorter (NAIA) | 24 | @ | Campbellsville (NAIA) | 14 | | |
| OAC | Marietta (D3) | 6 | @ | Capital (D3) | 38 | | |
| Kenyon (D3) | 12 | @ | Carnegie Mellon (D3) | 23 | | |
| MidW | Ripon (D3) | 28 | @ | Carroll WI (D3) | 10 | | |
| SAC | Mars Hill (D2) | 49 | @ | Carson-Newman (D2) | 61 | | |
| Denison (D3) | 14 | @ | Case Western Reserve (D3) | 45 | | |
| SUNY-Maritime (D3) | 13 | @ | Catholic (D3) | 46 | | |
| NE | Wagner | 10 | @ | Central Conn St | 35 | | |
| CUSA | SMU | 17 | @ | Central Florida | 31 | | |
| MAIAA | Emporia St (D2) | 14 | @ | Central Missouri (D2) | 42 | | |
| Dixie St (D2) | 14 | @ | Central Washington (D2) | 49 | | |
| Pomona-Pitzer (D3) | 3 | @ | Chapman (D3) | 17 | | |
| BigS | Gardner-Webb | 10 | @ | Charleston Southern | 13 | | |
| WVIAC | Shepherd (D2) | 12 | @ | Charleston WV (D2) | 21 | | |
| SoCon | Georgia Southern | 52 | @ | Chattanooga | 28 | | |
| PSAC | Kutztown (D2) | 31 | @ | Cheyney (D2) | 13 | | |
| PSAC | California PA (D2) | 52 | @ | Clarion (D2) | 20 | | |
| Savannah St | 17 | @ | Clark Atlanta (D2) | 14 | | |
| Mass Maritime (D3) | 6 | @ | Coast Guard (D3) | 30 | | |
| BigS | Liberty | 43 | @ | Coastal Carolina | 38 | | |
| NESCAA | Wesleyan (D3) | 7 | @ | Colby (D3) | 13 | | |
| B12 | #4 Texas | 38 | @ | Colorado | 14 | | |
| Austin (D3) | 36 | @ | Colorado College (D3) | 17 | | |
| RMAC | Mesa St (D2) | 27 | @ | Colorado Mines (D2) | 24 | | |
| MW | UNLV | 28 | @ | Colorado St | 41 | | |
| RMAC | Nebraska-Kearney (D2) | 41 | @ | Colorado St-Pueblo (D2) | 10 | | |
| Ivy | Princeton | 27 | @ | Columbia | 24 | | |
| West Alabama (D2) | 24 | @ | Concordia AL (NAIA) | 7 | | |
| Wisconsin Lutheran (D3) | 30 | @ | Concordia IL (D3) | 13 | | |
| GPAC | Northwestern IA (NAIA) | 49 | @ | Concordia NE (NAIA) | 2 | | |
| Maranatha Baptist (D3) | 6 | @ | Concordia WI (D3) | 43 | | |
| Buffalo St (D3) | 14 | @ | Cortland St (D3) | 35 | | |
| HAAC | Benedictine KS (NAIA) | 45 | @ | Culver-Stockton (NAIA) | 20 | | |
| MSC | Bethel TN (NAIA) | 16 | @ | Cumberland TN (NAIA) | 44 | | |
| MSC | Pikeville (NAIA) | 7 | @ | Cumberlands KY (NAIA) | 42 | | |
| GPAC | Morningside (NAIA) | 58 | @ | Dana (NAIA) | 7 | | |
| Pio | Campbell | 0 | @ | Dayton | 42 | | |
| HCA | Franklin (D3) | 30 | @ | Defiance (D3) | 14 | | |
| MEAC | Hampton | 17 | @ | Delaware St | 14 | | |
| Moravian (D3) | 7 | @ | Dickinson (D3) | 16 | | |
| GPAC | Sioux Falls (NAIA) | 37 | @ | Doane (NAIA) | 7 | | |
| NE | Albany NY | 33 | @ | Duquesne | 23 | | |
| PSAC | West Chester (D2) | 34 | @ | East Stroudsburg (D2) | 24 | | |
| ASWC | McMurry (D3) | 7 | @ | East Texas Baptist (D3) | 31 | | |
| Carroll MT (NAIA) | 48 | @ | Eastern Oregon (NAIA) | 10 | | |
| Gannon (D2) | 3 | @ | Edinboro (D2) | 40 | | |
| CIAA | Virginia St (D2) | 7 | @ | Elizabeth City St (D2) | 35 | | |
| CCIW | Augustana IL (D3) | 42 | @ | Elmhurst (D3) | 6 | | |
| SoCon | Furman | 10 | @ | Elon | 31 | | |
| Methodist (D3) | 7 | @ | Emory & Henry (D3) | 28 | | |
| Chowan (D2) | 21 | @ | Fayetteville St (D2) | 60 | | |
| MEAC | South Carolina St | 28 | @ | Florida A&M | 21 | | |
| RMAC | Western St CO (D2) | 17 | @ | Fort Lewis (D2) | 20 | | |
| NEF | Worcester St (D3) | 21 | @ | Framingham St (D3) | 42 | | |
| WAC | Hawaii | 32 | @ | Fresno St | 29 | OT | |
| ACF | Wesley (D3) | 38 | @ | Frostburg St (D3) | 6 | | |
| Wash & Jeff (D3) | 43 | @ | Geneva (NAIA) | 14 | | |
| MSC | Virginia-Wise (NAIA) | 35 | @ | Georgetown KY (NAIA) | 28 | | |
| ACC | Duke | 0 | @ | #19 Georgia Tech | 27 | | |
| Cen | Ursinus (D3) | 7 | @ | Gettysburg (D3) | 38 | | |
| SWAC | Prairie View A&M | 40 | @ | Grambling St | 16 | | |
| Kentucky Wesleyan (D2) | 34 | @ | Grand View (NAIA) | 13 | | |
| Huntingdon (D3) | 28 | @ | Greenville (D3) | 12 | | |
| MidW | Monmouth IL (D3) | 69 | @ | Grinnell (D3) | 0 | | |
| MIA | St Thomas (D3) | 30 | @ | Gustavus Adolphus (D3) | 22 | | |
| NESCAA | Trinity CT (D3) | 20 | @ | Hamilton (D3) | 15 | | |
| MIA | Augsburg (D3) | 24 | @ | Hamline (D3) | 21 | | |
| GSC | Southern Arkansas (D2) | 33 | @ | Harding (D2) | 39 | | |
| Lincoln MO (D2) | 43 | @ | Haskell (NAIA) | 37 | | |
| GPAC | Dordt (NAIA) | 0 | @ | Hastings (NAIA) | 35 | | |
| OAC | Otterbein (D3) | 52 | @ | Heidelberg (D3) | 14 | | |
| GLIAC | Findlay (D2) | 13 | @ | Hillsdale (D2) | 20 | | |
| NCA | Wittenberg (D3) | 44 | @ | Hiram (D3) | 7 | | |
| MIAA | Trine (D3) | 31 | @ | Hope (D3) | 30 | | |
| ASWC | Texas Lutheran (D3) | 28 | @ | Howard Payne (D3) | 21 | | |
| Azusa Pacific (NAIA) | 17 | @ | Humboldt St (D2) | 24 | | |
| WAC | Nevada | 49 | @ | Idaho | 14 | | |
| BSky | Montana St | 33 | @ | Idaho St | 21 | | |
| MidW | Lawrence (D3) | 16 | @ | Illinois College (D3) | 28 | | |
| CCIW | Carthage (D3) | 26 | @ | Illinois Wesleyan (D3) | 21 | | |
| PSAC | Slippery Rock (D2) | 16 | @ | Indiana PA (D2) | 23 | | |
| MVC | Illinois St | 57 | @ | Indiana St | 6 | | |
| GLIAC | Northwood (D2) | 23 | @ | Indianapolis (D2) | 27 | | |
| Stonehill (D2) | 34 | @ | Iona | 35 | OT | |
| B12 | Kansas | 35 | @ | Iowa St | 33 | | |
| MSFA | Olivet Nazarene (NAIA) | 28 | @ | Iowa Wesleyan (NAIA) | 12 | | |
| SWAC | Southern U. | 35 | @ | Jackson St | 28 | | |
| OVC | SE Missouri St | 17 | @ | Jacksonville St | 38 | | |
| CAAF | Hofstra | 0 | @ | James Madison | 56 | | |
| DAC | Minot St (NAIA) | 41 | @ | Jamestown (NAIA) | 48 | | |
| OAC | Wilmington (D3) | 17 | @ | John Carroll (D3) | 31 | | |
| Cen | Muhlenberg (D3) | 28 | @ | Johns Hopkins (D3) | 23 | | |
| CIAA | Livingstone (D2) | 32 | @ | Johnson C. Smith (D2) | 26 | | |
| McDaniel (D3) | 10 | @ | Juniata (D3) | 12 | | |
| B12 | #12 Texas Tech | 58 | @ | Kansas St | 28 | | |
| MAC | Akron | 30 | @ | Kent St | 27 | OT | |
| Central St OH (D2) | 29 | @ | Kentucky St (D2) | 31 | | |
| MidAC | Delaware Valley (D3) | 34 | @ | King's PA (D3) | 19 | | |
| MidW | St Norbert (D3) | 63 | @ | Knox (D3) | 24 | | |
| SCIAC | Redlands (D3) | 37 | @ | La Verne (D3) | 7 | | |
| Harvard | 27 | @ | Lafayette | 13 | | |
| Glenville St (D2) | 27 | @ | Lake Erie (D2) | 34 | | |
| MidW | Beloit (D3) | 27 | @ | Lake Forest (D3) | 21 | | |
| Rockford (D3) | 28 | @ | Lakeland (D3) | 33 | | |
| SIAC | Fort Valley St (D2) | 33 | @ | Lane (D2) | 30 | | |
| Cornell NY | 25 | @ | Lehigh | 24 | | |
| SAC | Tusculum (D2) | 48 | @ | Lenoir-Rhyne (D2) | 19 | | |
| NWC | Pacific Lutheran (D3) | 40 | @ | Lewis & Clark (D3) | 14 | | |
| Menlo (D3) | 0 | @ | Linfield (D3) | 9 | | |
| IIAC | Cornell IA (D3) | 0 | @ | Loras (D3) | 42 | | |
| SBC | Louisiana-Lafayette | 44 | @ | Louisiana-Monroe | 35 | | |
| IIAC | Central IA (D3) | 7 | @ | Luther (D3) | 26 | | |
| Northwestern MN (NAIA) | 49 | @ | Macalester (D3) | 13 | | |
| LaGrange (D3) | 49 | @ | MacMurray (D3) | 30 | | |
| MSFA | Marian (NAIA) | 37 | @ | Malone (NAIA) | 45 | | |
| Bucknell | 21 | @ | Marist | 17 | | |
| NSIC | Concordia-St Paul (D2) | 17 | @ | Mary (D2) | 7 | | |
| ASWC | Hardin-Simmons (D3) | 18 | @ | Mary Hardin-Baylor (D3) | 20 | | |
| North Carolina Wesleyan (D3) | 24 | @ | Maryville (D3) | 37 | | |
| CAAF | Delaware | 7 | @ | Massachusetts | 17 | | |
| Lock Haven (D2) | 14 | @ | Mercyhurst (D2) | 49 | | |
| ACC | Florida St | 41 | @ | Miami FL | 39 | | |
| MAC | Temple | 28 | @ | Miami OH | 10 | | |
| B10 | Illinois | 45 | @ | Michigan | 20 | | |
| B10 | Iowa | 13 | @ | #20 Michigan St | 16 | | |
| GLIAC | Ferris St (D2) | 7 | @ | Michigan Tech (D2) | 21 | | |
| HAAC | Evangel (NAIA) | 7 | @ | MidAmerica Nazarene (NAIA) | 51 | | |
| NESCAA | Amherst (D3) | 14 | @ | Middlebury (D3) | 31 | | |
| GPAC | Dakota Wesleyan (NAIA) | 19 | @ | Midland Lutheran (NAIA) | 14 | | |
| SIAC | Benedict (D2) | 10 | @ | Miles (D2) | 13 | | |
| PSAC | Bloomsburg (D2) | 49 | @ | Millersville (D2) | 24 | | |
| SCAC | DePauw (D3) | 13 | @ | Millsaps (D3) | 55 | | |
| Minnesota-Duluth (D2) | 52 | @ | Minn St-Moorhead (D3) | 10 | | |
| B10 | Indiana | 7 | @ | Minnesota | 16 | | |
| UMWAC | Martin Luther (NAIA) | 35 | @ | Minnesota-Morris (NAIA) | 7 | | |
| SEC | South Carolina | 31 | @ | Mississippi | 24 | | |
| ASWC | Louisiana College (D3) | 19 | @ | Mississippi College (D3) | 21 | | |
| GLFC | St Joseph's IN (D2) | 29 | @ | Missouri S&T (D2) | 38 | | |
| MAIAA | Washburn (D2) | 23 | @ | Missouri Southern (D2) | 0 | | |
| MVC | Western Illinois | 33 | @ | Missouri St | 21 | | |
| HAAC | Central Methodist (NAIA) | 0 | @ | Missouri Valley (NAIA) | 35 | | |
| Fort Hays St (D2) | 28 | @ | Missouri Western (D2) | 31 | | |
| NE | St Francis PA | 15 | @ | Monmouth NJ | 42 | | |
| Front | Montana St-Northern (NAIA) | 16 | @ | Montana Tech (NAIA) | 9 | | |
| Pio | Davidson | 13 | @ | Morehead St | 26 | | |
| MEAC | Bethune-Cookman | 31 | @ | Morgan St | 27 | | |
| Western Conn St (D3) | 40 | @ | Morrisville St (D3) | 6 | | |
| D3Ind | Husson (D3) | 16 | @ | Mount Ida (D3) | 12 | | |
| B12 | #3 Missouri | 52 | @ | Nebraska | 17 | | |
| MW | Wyoming | 0 | @ | New Mexico | 24 | | |
| RMAC | Chadron St (D2) | 56 | @ | New Mexico Highlands (D2) | 14 | | |
| Alcorn St | 10 | @ | New Mexico St | 45 | | |
| SAC | Catawba (D2) | 14 | @ | Newberry (D2) | 33 | | |
| NEF | Endicott (D3) | 27 | @ | Nichols (D3) | 20 | | |
| Connecticut | 12 | @ | #24 North Carolina | 38 | | |
| North Carolina A&T | 27 | vs | North Carolina Central | 28 | | |
| ACC | Boston College | 38 | @ | North Carolina St | 31 | | |
| CCIW | Millikin (D3) | 13 | @ | North Central (D3) | 31 | | |
| Southern Illinois | 27 | @ | North Dakota St | 35 | | |
| SBC | Florida Int'l | 42 | @ | North Texas | 10 | | |
| LSC | TAMU-Commerce (D2) | 38 | @ | Northeastern St OK (D2) | 37 | | |
| BSky | Sacramento St | 10 | @ | Northern Arizona | 42 | | |
| GLIAC | Saginaw Valley St (D2) | 38 | @ | Northern Michigan (D2) | 21 | | |
| NSIC | Minnesota-Crookston (D2) | 0 | @ | Northern St SD (D2) | 35 | | |
| Stanford | 21 | @ | Notre Dame | 28 | | |
| MAIAA | Pittsburg St (D2) | 10 | @ | NW Missouri St (D2) | 35 | | |
| Sterling (NAIA) | 14 | @ | NW Oklahoma St (NAIA) | 38 | | |
| NCA | Ohio Wesleyan (D3) | 15 | @ | Oberlin (D3) | 28 | | |
| SCIAC | Claremont-Mudd-Scripps (D3) | 0 | @ | Occidental (D3) | 38 | | |
| OAC | Muskingum (D3) | 35 | @ | Ohio Northern (D3) | 21 | | |
| B12 | Texas A&M | 28 | @ | #16 Oklahoma St | 56 | | |
| MIAA | Albion (D3) | 10 | @ | Olivet (D3) | 5 | | |
| GSC | Arkansas-Monticello (D2) | 44 | @ | Ouachita Baptist (D2) | 24 | | |
| NE10 | Merrimack (D2) | 31 | @ | Pace (D2) | 28 | | |
| Ivy | Dartmouth | 10 | @ | Pennsylvania | 23 | | |
| Western New England (D3) | 20 | @ | Plymouth St (D3) | 40 | | |
| BSky | Eastern Washington | 36 | @ | Portland St | 47 | | |
| North Greenville (D2) | 15 | @ | Presbyterian | 22 | | |
| B10 | #5 Penn State | 20 | @ | Purdue | 6 | | |
| MSFA | McKendree (NAIA) | 13 | @ | Quincy (NAIA) | 20 | | |
| Brown | 13 | @ | Rhode Island | 37 | | |
| Washington U. (D3) | 10 | @ | Rhodes (D3) | 28 | | |
| LL | RPI (D3) | 27 | @ | Rochester (D3) | 17 | | |
| Front | Montana-Western (NAIA) | 35 | @ | Rocky Mountain (NAIA) | 32 | | |
| Manchester (D3) | 31 | @ | Rose-Hulman (D3) | 35 | | |
| NE | Robert Morris | 28 | @ | Sacred Heart | 31 | | |
| NEF | Curry (D3) | 21 | @ | Salve Regina (D3) | 7 | | |
| Pio | Valparaiso | 14 | @ | San Diego | 42 | | |
| LSC | SW Oklahoma St (D2) | 21 | @ | SE Oklahoma St (D2) | 29 | | |
| SCAC | Centre (D3) | 28 | @ | Sewanee (D3) | 16 | | |
| USASC | Christopher Newport (D3) | 17 | @ | Shenandoah (D3) | 7 | | |
| C.W. Post (D2) | 10 | @ | Shippensburg (D2) | 27 | | |
| IIAC | Coe (D3) | 20 | @ | Simpson (D3) | 17 | | |
| McNeese St | 46 | @ | South Dakota St | 44 | 2OT | |
| DAC | Mayville St (NAIA) | 7 | @ | South Dakota Tech (NAIA) | 46 | | |
| P10 | Oregon | 10 | @ | #8 Southern Cal | 44 | | |
| CUSA | UTEP | 40 | @ | Southern Miss | 37 | 2OT | |
| Youngstown St | 7 | @ | Southern Utah | 14 | | |
| KCAC | Kansas Wesleyan (NAIA) | 40 | @ | Southwestern KS (NAIA) | 0 | | |
| E8 | Utica (D3) | 16 | @ | Springfield (D3) | 12 | | |
| MSFA | St Francis IL (NAIA) | 16 | @ | St Ambrose (NAIA) | 34 | | |
| NE10 | American Int'l (D2) | 37 | @ | St Anselm (D2) | 6 | | |
| CIAA | Shaw (D2) | 16 | @ | St Augustine's (D2) | 27 | | |
| Bemidji St (D2) | 14 | @ | St Cloud St (D2) | 48 | | |
| MSFA | Ohio Dominican (NAIA) | 0 | @ | St Francis IN (NAIA) | 35 | | |
| E8 | Hartwick (D3) | 31 | @ | St John Fisher (D3) | 28 | | |
| LL | Hobart (D3) | 16 | @ | St Lawrence (D3) | 10 | | |
| KCAC | McPherson (NAIA) | 28 | @ | St Mary KS (NAIA) | 30 | | |
| MIA | Carleton (D3) | 21 | @ | St Olaf (D3) | 7 | | |
| UMWAC | Crown (NAIA) | 51 | @ | St Scholastica (D3) | 13 | | |
| TPAC | Grove City (D3) | 27 | @ | St Vincent (D3) | 12 | | |
| MSFA | Walsh (NAIA) | 7 | @ | St Xavier (NAIA) | 23 | | |
| SLC | SE Louisiana St | 45 | @ | Stephen F. Austin | 48 | | |
| Merchant Marine (D3) | 35 | @ | Susquehanna (D3) | 37 | | |
| Ottawa (NAIA) | 23 | @ | SW Assem of God (NAIA) | 3 | | |
| Central Oklahoma (D2) | 43 | @ | SW Baptist (D2) | 40 | | |
| NSIC | Winona St (D2) | 28 | @ | SW Minnesota St (D2) | 35 | | |
| KCAC | Friends (NAIA) | 58 | @ | Tabor (NAIA) | 6 | | |
| LSC | TAMU-Kingsville (D2) | 27 | @ | Tarleton St (D2) | 16 | | |
| MW | San Diego St | 7 | @ | #20 TCU | 41 | | |
| Northern Illinois | 9 | @ | Tennessee | 13 | | |
| OVC | Eastern Kentucky | 33 | @ | Tennessee Tech | 12 | | |
| OVC | Tennessee St | 30 | @ | Tennessee-Martin | 27 | OT | |
| OK Panhandle St (D2) | 33 | @ | Texas College (NAIA) | 27 | | |
| Texas Southern | 39 | @ | Texas St-San Marcos | 63 | | |
| Grand Valley St (D2) | 49 | @ | Tiffin (D2) | 0 | | |
| MAC | #13 Ball St | 31 | @ | Toledo | 0 | | |
| CAAF | Northeastern | 35 | @ | Towson | 17 | | |
| MSFA | William Penn (NAIA) | 25 | @ | Trinity Int'l (NAIA) | 24 | | |
| Nebraska-Omaha (D2) | 20 | @ | Truman St (D2) | 26 | | |
| Army | 44 | @ | Tulane | 13 | | |
| CUSA | Rice | 28 | @ | #22 Tulsa | 63 | | |
| Northern Colorado | 30 | @ | UC-Davis | 34 | | |
| P10 | Washington St | 3 | @ | UCLA | 28 | | |
| NEF | MIT (D3) | 20 | @ | UMass-Dartmouth (D3) | 51 | | |
| Wayne St NE (D2) | 34 | @ | Upper Iowa (D2) | 14 | | |
| MSFA | Taylor (NAIA) | 14 | @ | Urbana (NAIA) | 13 | | |
| WIAC | UW-Oshkosh (D3) | 0 | @ | UW-Eau Claire (D3) | 34 | | |
| WIAC | UW-Stout (D3) | 46 | @ | UW-Platteville (D3) | 31 | | |
| WIAC | UW-Stevens Point (D3) | 30 | @ | UW-River Falls (D3) | 36 | | |
| WIAC | UW-La Crosse (D3) | 0 | @ | UW-Whitewater (D3) | 31 | | |
| DAC | Dickinson St (NAIA) | 28 | @ | Valley City St (NAIA) | 21 | | |
| SEC | Auburn | 13 | @ | #10 Vanderbilt | 14 | | |
| ACC | Maryland | 0 | @ | Virginia | 31 | | |
| Western Kentucky | 13 | @ | #15 Virginia Tech | 27 | | |
| CIAA | St Paul's (D2) | 17 | @ | Virginia Union (D2) | 10 | | |
| Richmond | 56 | @ | VMI | 18 | | |
| NCA | Allegheny (D3) | 7 | @ | Wabash (D3) | 48 | | |
| Peru St (NAIA) | 47 | @ | Waldorf (NAIA) | 21 | | |
| ODC | Randolph-Macon (D3) | 16 | @ | Washington and Lee (D3) | 28 | | |
| UNC-Pembroke (D2) | 35 | @ | Webber Int'l (NAIA) | 2 | | |
| BSky | Montana | 28 | @ | Weber St | 45 | | |
| GSC | Henderson St (D2) | 49 | @ | West Georgia (D2) | 10 | | |
| LSC | Midwestern St (D2) | 14 | @ | West Texas A&M (D2) | 42 | | |
| BigE | Rutgers | 17 | @ | West Virginia | 24 | | |
| WVIAC | Concord (D2) | 7 | @ | West Virginia St (D2) | 41 | | |
| Union KY (NAIA) | 45 | @ | West Virginia Tech (D2) | 27 | | |
| Samford | 21 | @ | Western Carolina | 6 | | |
| MAC | Ohio U. | 20 | @ | Western Michigan | 41 | | |
| RMAC | Adams St (D2) | 28 | @ | Western New Mexico (D2) | 21 | | |
| Western Washington (D2) | 24 | @ | Western Oregon (D2) | 13 | | |
| NEF | Maine Maritime (D3) | 33 | @ | Westfield St (D3) | 28 | | |
| UMWAC | Principia (D3) | 6 | @ | Westminster MO (D3) | 48 | | |
| TPAC | Thiel (D3) | 10 | @ | Westminster PA (D3) | 16 | | |
| CCIW | North Park (D3) | 28 | @ | Wheaton (D3) | 56 | | |
| SCIAC | Cal Lutheran (D3) | 32 | @ | Whittier (D3) | 7 | | |
| NWC | Willamette (D3) | 32 | @ | Whitworth (D3) | 23 | | |
| MidAC | Lycoming (D3) | 21 | @ | Widener (D3) | 17 | | |
| MidAC | Lebanon Valley (D3) | 28 | @ | Wilkes (D3) | 21 | | |
| CAAF | Villanova | 38 | @ | William & Mary | 28 | | |
| NJAC | Montclair St (D3) | 14 | @ | William Paterson (D3) | 13 | | |
| MEAC | Howard | 10 | @ | Winston-Salem St | 34 | | |
| B10 | #16 Ohio State | 20 | @ | Wisconsin | 17 | | |
| NCA | Earlham (D3) | 14 | @ | Wooster (D3) | 16 | | |
| LL | Union NY (D3) | 16 | @ | WPI (D3) | 19 | | |
| Seton Hill (NAIA) | 35 | @ | WV Wesleyan (D2) | 32 | | |
| Holy Cross | 28 | @ | Yale | 31 | OT | |
| Tuesday, 7 Oct 2008 |
| SBC | Troy | 30 | @ | Florida Atlantic | 17 | | |