| Thursday, 25 Sep 2008 |
| SWAC | Mississippi Valley St | 7 | @ | Alabama St | 47 | | |
| WVIAC | Fairmont St (D2) | 13 | @ | Glenville St (D2) | 23 | | |
| Pikeville (NAIA) | 20 | @ | Kentucky Christian (NAIA) | 14 | | |
| GSC | Harding (D2) | 0 | @ | North Alabama (D2) | 52 | | |
| P10 | #10 Southern Cal | 21 | @ | Oregon St | 27 | | |
| Central Methodist (NAIA) | 19 | @ | Tennessee Tech | 47 | | |
| CUSA | SMU | 27 | @ | Tulane | 34 | | |
| Friday, 26 Sep 2008 |
| NE10 | Stonehill (D2) | 14 | @ | Bentley (D2) | 17 | | |
| BigE | #22 Connecticut | 26 | @ | Louisville | 21 | | |
| Hofstra | 43 | @ | Stony Brook | 3 | | |
| Saturday, 27 Sep 2008 |
| RMAC | New Mexico Highlands (D2) | 13 | @ | Adams St (D2) | 7 | | |
| Cincinnati | 17 | @ | Akron | 15 | | |
| Central IA (D3) | 13 | @ | Albion (D3) | 12 | | |
| SWAC | Southern U. | 15 | @ | Alcorn St | 12 | | |
| NCA | Oberlin (D3) | 13 | @ | Allegheny (D3) | 24 | | |
| UW-River Falls (D3) | 25 | @ | Alma (D3) | 20 | | |
| Husson (D3) | 7 | @ | American Int'l (D2) | 35 | | |
| Presbyterian | 14 | @ | Appalachian St | 48 | | |
| GSC | Arkansas Tech (D2) | 38 | @ | Arkansas-Monticello (D2) | 35 | | |
| SWAC | Alabama A&M | 23 | @ | Arkansas-Pine Bluff | 17 | | |
| NE10 | St Anselm (D2) | 7 | @ | Assumption (D2) | 16 | | |
| SEC | Tennessee | 12 | @ | Auburn | 14 | | |
| MIA | St Olaf (D3) | 21 | @ | Augsburg (D3) | 49 | | |
| Centre (D3) | 22 | @ | Austin (D3) | 17 | | |
| CSFL | Peru St (NAIA) | 32 | @ | Bacone (NAIA) | 42 | | |
| MAC | Kent St | 20 | @ | #23 Ball St | 41 | | |
| Mount Ida (D3) | 34 | @ | Becker (D3) | 19 | | |
| MidW | Knox (D3) | 0 | @ | Beloit (D3) | 38 | | |
| NSIC | Northern St SD (D2) | 20 | @ | Bemidji St (D2) | 31 | | |
| SIAC | Albany St GA (D2) | 10 | @ | Benedict (D2) | 13 | | |
| HAAC | Baker (NAIA) | 35 | @ | Benedictine KS (NAIA) | 24 | | |
| MSC | Belhaven (NAIA) | 21 | @ | Bethel TN (NAIA) | 31 | | |
| MEAC | Norfolk St | 17 | @ | Bethune-Cookman | 33 | | |
| LaGrange (D3) | 61 | @ | Blackburn (D3) | 0 | | |
| Kalamazoo (D3) | 15 | @ | Bluffton (D3) | 23 | | |
| Rhode Island | 0 | @ | Boston College | 42 | | |
| NESCAA | Amherst (D3) | 31 | @ | Bowdoin (D3) | 24 | | |
| Lenoir-Rhyne (D2) | 40 | @ | Brevard (D2) | 14 | | |
| GPAC | Midland Lutheran (NAIA) | 20 | @ | Briar Cliff (NAIA) | 7 | | |
| Ivy | Harvard | 22 | @ | Brown | 24 | | |
| Bloomsburg (D2) | 13 | @ | C.W. Post (D2) | 6 | | |
| Colorado St | 7 | @ | #23 California | 42 | | |
| PSAC | Indiana PA (D2) | 19 | @ | California PA (D2) | 21 | | |
| OAC | Wilmington (D3) | 28 | @ | Capital (D3) | 48 | | |
| Macalester (D3) | 13 | @ | Carleton (D3) | 33 | | |
| Hiram (D3) | 6 | @ | Carnegie Mellon (D3) | 41 | | |
| Front | Montana Tech (NAIA) | 13 | @ | Carroll MT (NAIA) | 31 | | |
| Campbell | 36 | @ | Carthage (D3) | 27 | | |
| MAC | Buffalo | 25 | @ | Central Michigan | 27 | | |
| LSC | TAMU-Commerce (D2) | 13 | @ | Central Oklahoma (D2) | 21 | | |
| RMAC | Nebraska-Kearney (D2) | 14 | @ | Chadron St (D2) | 17 | | |
| Whitworth (D3) | 7 | @ | Chapman (D3) | 7 | | |
| North Greenville (D2) | 0 | @ | Charleston Southern | 27 | | |
| Virginia Union (D2) | 51 | @ | Chowan (D2) | 28 | | |
| ACC | Maryland | 20 | @ | Clemson | 17 | | |
| IIAC | Loras (D3) | 23 | @ | Coe (D3) | 21 | | |
| NESCAA | Middlebury (D3) | 19 | @ | Colby (D3) | 24 | | |
| Trinity TX (D3) | 35 | @ | Colorado College (D3) | 10 | | |
| RMAC | Colorado St-Pueblo (D2) | 14 | @ | Colorado Mines (D2) | 21 | | |
| WVIAC | Charleston WV (D2) | 42 | @ | Concord (D2) | 17 | | |
| MIA | Bethel MN (D3) | 7 | @ | Concordia-Moorhead (D3) | 24 | | |
| Augustana SD (D2) | 42 | @ | Concordia-St Paul (D2) | 21 | | |
| Ivy | Yale | 14 | @ | Cornell NY | 17 | | |
| UMWAC | Northwestern MN (NAIA) | 38 | @ | Crown (NAIA) | 34 | | |
| MSC | Cumberland TN (NAIA) | 37 | @ | Cumberlands KY (NAIA) | 52 | | |
| NEF | Western New England (D3) | 7 | @ | Curry (D3) | 40 | | |
| DAC | South Dakota Tech (NAIA) | 30 | @ | Dakota St (NAIA) | 18 | | |
| GPAC | Hastings (NAIA) | 28 | @ | Dakota Wesleyan (NAIA) | 27 | | |
| New Hampshire | 42 | @ | Dartmouth | 6 | | |
| Pio | Jacksonville FL | 35 | @ | Davidson | 38 | | |
| Albany NY | 7 | @ | Delaware | 38 | | |
| Central Conn St | 28 | @ | Delaware St | 10 | | |
| Salisbury (D3) | 27 | @ | Delaware Valley (D3) | 41 | | |
| GSC | Ouachita Baptist (D2) | 17 | @ | Delta St (D2) | 35 | | |
| NCA | Wooster (D3) | 21 | @ | Denison (D3) | 10 | | |
| SCAC | Sewanee (D3) | 20 | @ | DePauw (D3) | 27 | | |
| DAC | Jamestown (NAIA) | 21 | @ | Dickinson St (NAIA) | 24 | | |
| GPAC | Nebraska Wesleyan (NAIA) | 34 | @ | Dordt (NAIA) | 0 | | |
| Pio | San Diego | 43 | @ | Drake | 17 | | |
| IIAC | Buena Vista (D3) | 20 | @ | Dubuque (D3) | 3 | | |
| ACC | Virginia | 3 | @ | Duke | 31 | | |
| Dayton | 16 | @ | Duquesne | 24 | | |
| CUSA | Houston | 41 | @ | East Carolina | 24 | | |
| LSC | Northeastern St OK (D2) | 49 | @ | East Central OK (D2) | 55 | | |
| PSAC | Cheyney (D2) | 12 | @ | East Stroudsburg (D2) | 52 | | |
| OVC | Jacksonville St | 23 | @ | Eastern Illinois | 10 | OT | |
| OVC | Austin Peay | 10 | @ | Eastern Kentucky | 13 | | |
| MAC | Northern Illinois | 37 | @ | Eastern Michigan | 0 | | |
| LSC | Abilene Christian (D2) | 56 | @ | Eastern New Mexico (D2) | 11 | | |
| Rocky Mountain (NAIA) | 55 | @ | Eastern Oregon (NAIA) | 76 | | |
| BSky | Idaho St | 31 | @ | Eastern Washington | 45 | | |
| NAIAInd | Webber Int'l (NAIA) | 17 | @ | Edward Waters (NAIA) | 20 | | |
| Chicago (D3) | 6 | @ | Elmhurst (D3) | 27 | | |
| Samford | 17 | @ | Elon | 23 | | |
| MAIAA | Missouri Southern (D2) | 19 | @ | Emporia St (D2) | 18 | | |
| NEF | Salve Regina (D3) | 20 | @ | Endicott (D3) | 17 | | |
| HAAC | Missouri Valley (NAIA) | 47 | @ | Evangel (NAIA) | 10 | | |
| Apprentice (D3) | 21 | @ | FDU-Florham (D3) | 23 | | |
| GLIAC | Northern Michigan (D2) | 24 | @ | Ferris St (D2) | 31 | | |
| USASC | Shenandoah (D3) | 12 | @ | Ferrum (D3) | 14 | | |
| NEF | Framingham St (D3) | 34 | @ | Fitchburg St (D3) | 41 | | |
| SEC | Mississippi | 31 | @ | #20 Florida | 30 | | |
| Colorado | 21 | vs | Florida St | 39 | | |
| Pat | Colgate | 31 | @ | Fordham | 24 | | |
| Truman St (D2) | 27 | @ | Fort Hays St (D2) | 7 | | |
| SIAC | Tuskegee (D2) | 20 | @ | Fort Valley St (D2) | 16 | | |
| Juniata (D3) | 0 | @ | Franklin & Marshall (D3) | 14 | | |
| KCAC | Bethany KS (NAIA) | 6 | @ | Friends (NAIA) | 42 | | |
| Widener (D3) | 30 | @ | Frostburg St (D3) | 24 | | |
| SoCon | Chattanooga | 10 | @ | Furman | 35 | | |
| Clarion (D2) | 24 | @ | Gannon (D2) | 31 | | |
| Sam Houston St | 49 | @ | Gardner-Webb | 33 | | |
| Pat | Holy Cross | 38 | @ | Georgetown DC | 14 | | |
| SEC | #2 Alabama | 41 | @ | #12 Georgia | 30 | | |
| SoCon | Wofford | 38 | @ | Georgia Southern | 37 | | |
| HAAC | Avila (NAIA) | 9 | @ | Graceland (NAIA) | 8 | | |
| Langston (D2) | 2 | @ | Grambling St | 13 | | |
| GLIAC | Michigan Tech (D2) | 6 | @ | Grand Valley St (D2) | 52 | | |
| Maryville (D3) | 17 | @ | Greensboro (D3) | 16 | | |
| Blackburn (D3) | 0 | @ | Greenville (D3) | 59 | | |
| ODC | Guilford (D3) | 14 | @ | Hampden-Sydney (D3) | 35 | | |
| ASWC | Mississippi College (D3) | 27 | @ | Hardin-Simmons (D3) | 35 | | |
| Waldorf (NAIA) | 10 | @ | Haskell (NAIA) | 39 | | |
| WAC | San Jose St | 20 | @ | Hawaii | 17 | | |
| GLIAC | Ashland (D2) | 24 | @ | Hillsdale (D2) | 17 | | |
| Susquehanna (D3) | 14 | @ | Hobart (D3) | 27 | | |
| Wheaton (D3) | 47 | @ | Hope (D3) | 7 | | |
| D2Ind | Western Oregon (D2) | 44 | @ | Humboldt St (D2) | 28 | | |
| MacMurray (D3) | 20 | @ | Huntingdon (D3) | 49 | | |
| B10 | Michigan St | 42 | @ | Indiana | 29 | | |
| SE Missouri St | 24 | @ | Indiana St | 21 | | |
| Pace (D2) | 26 | @ | Iona | 30 | | |
| B10 | #20 Northwestern | 22 | @ | Iowa | 17 | | |
| Grand View (NAIA) | 23 | @ | Iowa Wesleyan (NAIA) | 36 | | |
| OAC | Heidelberg (D3) | 15 | @ | John Carroll (D3) | 17 | | |
| Louisiana-Lafayette | 37 | @ | Kansas St | 45 | | |
| NJAC | Cortland St (D3) | 32 | @ | Kean (D3) | 28 | | |
| Western Kentucky | 3 | @ | #21 Kentucky | 41 | | |
| SW Baptist (D2) | 34 | @ | Kentucky Wesleyan (D2) | 14 | | |
| NCA | Wabash (D3) | 55 | @ | Kenyon (D3) | 13 | | |
| PSAC | West Chester (D2) | 49 | @ | Kutztown (D2) | 8 | | |
| Willamette (D3) | 44 | @ | La Verne (D3) | 0 | | |
| Pennsylvania | 17 | @ | Lafayette | 24 | | |
| Adrian (D3) | 37 | @ | Lake Erie (D2) | 17 | | |
| UNC-Pembroke (D2) | 47 | @ | Lane (D2) | 28 | | |
| MidW | Grinnell (D3) | 32 | @ | Lawrence (D3) | 16 | | |
| GLFC | St Joseph's IN (D2) | 31 | @ | Lincoln MO (D2) | 10 | | |
| CIAA | Livingstone (D2) | 27 | @ | Lincoln PA (D2) | 10 | | |
| HAAC | Culver-Stockton (NAIA) | 12 | @ | Lindenwood (NAIA) | 68 | | |
| Southern Oregon (NAIA) | 7 | @ | Linfield (D3) | 14 | | |
| PSAC | Edinboro (D2) | 31 | @ | Lock Haven (D2) | 0 | | |
| SEC | Mississippi St | 24 | @ | #14 LSU | 34 | | |
| Bridgewater VA (D3) | 17 | @ | Lycoming (D3) | 34 | | |
| CAAF | James Madison | 24 | @ | Maine | 10 | | |
| NEF | Bridgewater St MA (D3) | 31 | @ | Maine Maritime (D3) | 41 | | |
| OAC | Baldwin-Wallace (D3) | 45 | @ | Marietta (D3) | 16 | | |
| Sacred Heart | 28 | @ | Marist | 16 | | |
| SAC | Catawba (D2) | 24 | @ | Mars Hill (D2) | 7 | | |
| DAC | Black Hills St (NAIA) | 48 | @ | Mayville St (NAIA) | 2 | | |
| Cen | Dickinson (D3) | 13 | @ | McDaniel (D3) | 20 | | |
| ASWC | Mary Hardin-Baylor (D3) | 46 | @ | McMurry (D3) | 0 | | |
| Southern Virginia (NAIA) | 7 | @ | McNeese St | 63 | | |
| KCAC | Southwestern KS (NAIA) | 7 | @ | McPherson (NAIA) | 41 | | |
| Arkansas St | 17 | @ | Memphis | 29 | | |
| Whittier (D3) | 20 | @ | Menlo (D3) | 38 | | |
| LL | St Lawrence (D3) | 17 | @ | Merchant Marine (D3) | 23 | | |
| Slippery Rock (D2) | 10 | @ | Mercyhurst (D2) | 34 | | |
| NE10 | Southern Conn St (D2) | 40 | @ | Merrimack (D2) | 26 | | |
| RMAC | Fort Lewis (D2) | 13 | @ | Mesa St (D2) | 35 | | |
| ACC | North Carolina | 28 | @ | Miami FL | 24 | | |
| B10 | Wisconsin | 25 | @ | Michigan | 27 | | |
| LSC | Angelo St (D2) | 3 | @ | Midwestern St (D2) | 17 | | |
| SIAC | Clark Atlanta (D2) | 26 | @ | Miles (D2) | 21 | | |
| Winona St (D2) | 32 | @ | Minn St-Mankato (D2) | 35 | | |
| NSIC | Minn St-Moorhead (D3) | 16 | @ | Minnesota-Crookston (D2) | 20 | | |
| Mary (D2) | 7 | @ | Minnesota-Duluth (D2) | 44 | | |
| UMWAC | St Scholastica (D3) | 7 | @ | Minnesota-Morris (NAIA) | 21 | | |
| DAC | Valley City St (NAIA) | 35 | @ | Minot St (NAIA) | 44 | | |
| Butler | 41 | @ | Missouri S&T (D2) | 15 | | |
| NEF | Nichols (D3) | 42 | @ | MIT (D3) | 43 | | |
| MidW | Carroll WI (D3) | 20 | @ | Monmouth IL (D3) | 41 | | |
| Central Washington (D2) | 35 | @ | Montana | 38 | | |
| South Dakota | 18 | @ | Montana St | 37 | | |
| Front | Montana St-Northern (NAIA) | 31 | @ | Montana-Western (NAIA) | 9 | | |
| Brockport St (D3) | 14 | @ | Montclair St (D3) | 16 | | |
| Johns Hopkins (D3) | 10 | @ | Moravian (D3) | 33 | | |
| St Francis PA | 21 | @ | Morehead St | 36 | | |
| Rose-Hulman (D3) | 27 | @ | Mt St Joseph (D3) | 21 | | |
| Cen | Gettysburg (D3) | 21 | @ | Muhlenberg (D3) | 42 | | |
| OVC | Tennessee-Martin | 63 | @ | Murray St | 38 | | |
| OAC | Mount Union (D3) | 51 | @ | Muskingum (D3) | 13 | | |
| #19 Virginia Tech | 35 | @ | Nebraska | 30 | | |
| NW Missouri St (D2) | 42 | @ | Nebraska-Omaha (D2) | 0 | | |
| Morrisville St (D3) | 31 | @ | New Jersey (D3) | 41 | | |
| New Mexico | 35 | @ | New Mexico St | 24 | | |
| SAC | Carson-Newman (D2) | 21 | @ | Newberry (D2) | 27 | | |
| Coastal Carolina | 20 | @ | North Carolina A&T | 7 | | |
| #13 South Florida | 41 | @ | North Carolina St | 10 | | |
| USASC | Methodist (D3) | 0 | @ | North Carolina Wesleyan (D3) | 42 | | |
| Benedictine IL (D3) | 10 | @ | North Park (D3) | 35 | | |
| UC-Davis | 10 | @ | Northeastern | 27 | | |
| BSky | Northern Arizona | 25 | @ | Northern Colorado | 22 | | |
| GPAC | Dana (NAIA) | 14 | @ | Northwestern IA (NAIA) | 54 | | |
| SE Oklahoma St (D2) | 12 | @ | Northwestern St | 63 | | |
| GLIAC | Findlay (D2) | 24 | @ | Northwood (D2) | 31 | | |
| Purdue | 21 | @ | Notre Dame | 38 | | |
| MSFA | McKendree (NAIA) | 0 | @ | Ohio Dominican (NAIA) | 59 | | |
| OAC | Otterbein (D3) | 37 | @ | Ohio Northern (D3) | 7 | | |
| B10 | Minnesota | 21 | @ | #24 Ohio State | 34 | | |
| VMI | 31 | @ | Ohio U. | 51 | | |
| NCA | Wittenberg (D3) | 32 | @ | Ohio Wesleyan (D3) | 0 | | |
| Tabor (NAIA) | 15 | @ | OK Panhandle St (D2) | 31 | | |
| #21 TCU | 10 | @ | #2 Oklahoma | 35 | | |
| Troy | 24 | @ | #17 Oklahoma St | 55 | | |
| North Central (D3) | 37 | @ | Olivet (D3) | 7 | | |
| MSFA | Malone (NAIA) | 43 | @ | Olivet Nazarene (NAIA) | 3 | | |
| KCAC | St Mary KS (NAIA) | 14 | @ | Ottawa (NAIA) | 35 | | |
| B10 | Illinois | 24 | @ | #7 Penn State | 38 | | |
| MAIAA | Central Missouri (D2) | 28 | @ | Pittsburg St (D2) | 49 | | |
| UMass-Dartmouth (D3) | 10 | @ | Plymouth St (D3) | 30 | | |
| Morehouse (D2) | 17 | @ | Prairie View A&M | 21 | | |
| Lehigh | 7 | @ | Princeton | 10 | | |
| UW-Whitewater (D3) | 60 | @ | Puget Sound (D3) | 7 | | |
| ODC | Catholic (D3) | 20 | @ | Randolph-Macon (D3) | 32 | | |
| SCAC | Millsaps (D3) | 49 | @ | Rhodes (D3) | 2 | | |
| North Texas | 20 | @ | Rice | 77 | | |
| MidW | Illinois College (D3) | 20 | @ | Ripon (D3) | 45 | | |
| NE | Monmouth NJ | 34 | @ | Robert Morris | 26 | | |
| NJAC | William Paterson (D3) | 24 | @ | Rowan (D3) | 39 | | |
| LL | WPI (D3) | 21 | @ | RPI (D3) | 35 | | |
| Morgan St | 0 | @ | Rutgers | 38 | | |
| BSky | Portland St | 31 | @ | Sacramento St | 41 | | |
| GLIAC | Indianapolis (D2) | 14 | @ | Saginaw Valley St (D2) | 11 | | |
| Idaho | 17 | @ | San Diego St | 45 | | |
| Howard | 49 | vs | Savannah St | 21 | | |
| North Dakota (D2) | 35 | @ | SE Louisiana St | 38 | | |
| Shepherd (D2) | 14 | @ | Seton Hill (NAIA) | 24 | | |
| CIAA | Bowie St (D2) | 10 | @ | Shaw (D2) | 41 | | |
| PSAC | Millersville (D2) | 14 | @ | Shippensburg (D2) | 35 | | |
| Faulkner (NAIA) | 0 | @ | Shorter (NAIA) | 42 | | |
| IIAC | Luther (D3) | 9 | @ | Simpson (D3) | 28 | | |
| GPAC | Concordia NE (NAIA) | 0 | @ | Sioux Falls (NAIA) | 47 | | |
| Alabama-Birmingham | 13 | @ | South Carolina | 26 | | |
| GSC | Henderson St (D2) | 42 | @ | Southern Arkansas (D2) | 17 | | |
| MVC | Northern Iowa | 24 | @ | Southern Illinois | 27 | | |
| E8 | Alfred (D3) | 17 | @ | Springfield (D3) | 14 | | |
| CIAA | Elizabeth City St (D2) | 24 | vs | St Augustine's (D2) | 13 | | |
| Upper Iowa (D2) | 28 | @ | St Cloud St (D2) | 54 | | |
| MSFA | Urbana (NAIA) | 23 | @ | St Francis IL (NAIA) | 27 | | |
| MSFA | St Ambrose (NAIA) | 14 | @ | St Francis IN (NAIA) | 43 | | |
| E8 | Ithaca (D3) | 6 | @ | St John Fisher (D3) | 37 | | |
| MIA | Gustavus Adolphus (D3) | 17 | @ | St John's MN (D3) | 31 | | |
| MidW | Lake Forest (D3) | 0 | @ | St Norbert (D3) | 62 | | |
| CIAA | Johnson C. Smith (D2) | 9 | @ | St Paul's (D2) | 24 | | |
| MIA | Hamline (D3) | 21 | @ | St Thomas (D3) | 24 | | |
| TPAC | Waynesburg (D3) | 21 | @ | St Vincent (D3) | 12 | | |
| South Dakota St | 50 | @ | Stephen F. Austin | 48 | | |
| KCAC | Bethel KS (NAIA) | 3 | @ | Sterling (NAIA) | 24 | | |
| Kentucky St (D2) | 37 | @ | Stillman (D2) | 30 | | |
| ASWC | Howard Payne (D3) | 0 | @ | Sul Ross St (D3) | 17 | | |
| Norwich (D3) | 20 | @ | SUNY-Maritime (D3) | 34 | | |
| Kansas Wesleyan (NAIA) | 52 | @ | SW Assem of God (NAIA) | 13 | | |
| NSIC | Wayne St NE (D2) | 34 | @ | SW Minnesota St (D2) | 28 | | |
| LSC | Tarleton St (D2) | 24 | @ | SW Oklahoma St (D2) | 21 | | |
| BigE | Pittsburgh | 34 | @ | Syracuse | 24 | | |
| LSC | West Texas A&M (D2) | 55 | @ | TAMU-Kingsville (D2) | 35 | | |
| MAC | Western Michigan | 7 | @ | Temple | 3 | | |
| Florida A&M | 28 | vs | Tennessee St | 21 | | |
| Arkansas | 10 | @ | #5 Texas | 52 | | |
| Army | 17 | @ | Texas A&M | 21 | | |
| ASWC | East Texas Baptist (D3) | 26 | @ | Texas Lutheran (D3) | 14 | | |
| Concordia AL (NAIA) | 27 | @ | Texas Southern | 45 | | |
| Southern Utah | 34 | @ | Texas St-San Marcos | 20 | | |
| SoCon | Western Carolina | 14 | @ | The Citadel | 34 | | |
| Geneva (NAIA) | 31 | @ | Thiel (D3) | 17 | | |
| Westminster PA (D3) | 10 | @ | Thomas More (D3) | 31 | | |
| Florida Int'l | 35 | @ | Toledo | 16 | | |
| Columbia | 24 | @ | Towson | 31 | | |
| Franklin (D3) | 27 | @ | Trine (D3) | 30 | | |
| UMWAC | Martin Luther (NAIA) | 41 | @ | Trinity Bible (NAIA) | 16 | | |
| MSFA | St Xavier (NAIA) | 46 | @ | Trinity Int'l (NAIA) | 0 | | |
| NESCAA | Bates (D3) | 7 | @ | Tufts (D3) | 34 | | |
| Central Arkansas | 34 | @ | Tulsa | 62 | | |
| Fresno St | 36 | @ | UCLA | 31 | | |
| MSC | Georgetown KY (NAIA) | 28 | @ | Union KY (NAIA) | 35 | | |
| LL | Rochester (D3) | 29 | @ | Union NY (D3) | 25 | | |
| Nevada | 49 | @ | UNLV | 27 | | |
| Weber St | 21 | @ | #8 Utah | 37 | | |
| CUSA | Central Florida | 13 | @ | UTEP | 58 | | |
| Augustana IL (D3) | 9 | @ | UW-Platteville (D3) | 13 | | |
| Azusa Pacific (NAIA) | 9 | @ | UW-Stevens Point (D3) | 10 | | |
| CAAF | Richmond | 20 | @ | Villanova | 26 | | |
| CIAA | Fayetteville St (D2) | 23 | @ | Virginia St (D2) | 13 | | |
| MSC | Lambuth (NAIA) | 51 | @ | Virginia-Wise (NAIA) | 40 | | |
| Bryant (D2) | 24 | @ | Wagner | 14 | | |
| Navy | 24 | @ | #22 Wake Forest | 17 | | |
| MSFA | Quincy (NAIA) | 27 | @ | Walsh (NAIA) | 25 | | |
| IIAC | Cornell IA (D3) | 14 | @ | Wartburg (D3) | 37 | | |
| TPAC | Grove City (D3) | 21 | @ | Wash & Jeff (D3) | 49 | | |
| MAIAA | Missouri Western (D2) | 17 | @ | Washburn (D2) | 21 | | |
| P10 | Stanford | 35 | @ | Washington | 28 | | |
| Averett (D3) | 23 | @ | Washington and Lee (D3) | 31 | | |
| P10 | #21 Oregon | 63 | @ | Washington St | 14 | | |
| Tiffin (D2) | 18 | @ | Wayne St MI (D2) | 34 | | |
| GSC | Valdosta St (D2) | 33 | @ | West Alabama (D2) | 14 | | |
| WVIAC | WV Wesleyan (D2) | 0 | @ | West Liberty St (D2) | 46 | | |
| Marshall | 3 | @ | West Virginia | 27 | | |
| Campbellsville (NAIA) | 57 | @ | West Virginia Tech (D2) | 47 | | |
| Buffalo St (D3) | 20 | @ | Western Conn St (D3) | 22 | | |
| RMAC | Western New Mexico (D2) | 24 | @ | Western St CO (D2) | 53 | | |
| Dixie St (D2) | 27 | @ | Western Washington (D2) | 29 | | |
| Coast Guard (D3) | 16 | @ | Westfield St (D3) | 13 | | |
| Eureka (D3) | 25 | @ | Westminster MO (D3) | 42 | | |
| Christopher Newport (D3) | 21 | @ | Wilkes (D3) | 20 | | |
| HAAC | MidAmerica Nazarene (NAIA) | 37 | @ | William Jewell (NAIA) | 16 | | |
| MSFA | Taylor (NAIA) | 10 | @ | William Penn (NAIA) | 13 | | |
| NESCAA | Trinity CT (D3) | 20 | @ | Williams (D3) | 17 | | |
| SAC | Tusculum (D2) | 33 | @ | Wingate (D2) | 37 | | |
| MEAC | South Carolina St | 43 | @ | Winston-Salem St | 17 | | |
| NEF | Mass Maritime (D3) | 7 | @ | Worcester St (D3) | 42 | | |
| Bowling Green | 45 | @ | Wyoming | 16 | | |
| Liberty | 31 | @ | Youngstown St | 28 | | |
| Sunday, 28 Sep 2008 |
| NESCAA | Hamilton (D3) | 17 | @ | Wesleyan (D3) | 7 | | |
| Tuesday, 30 Sep 2008 |
| SBC | Florida Atlantic | 13 | @ | Middle Tennessee St | 14 | | |
| Wednesday, 1 Oct 2008 |
| WAC | Louisiana Tech | 3 | @ | #12 Boise St | 38 | | |