| Thursday, 24 Aug 2006 |
| Dixie StD2 | 14 | @ | Mesa StD2 | 42 | | |
| Truman StD2 | 16 | @ | Minn St-MankatoD2 | 34 | | |
| Bethel TNNAIA | 10 | @ | TusculumD2 | 17 | | |
| Saturday, 26 Aug 2006 |
SIAC | MorehouseD2 | 25 | @ | BenedictD2 | 24 | | |
| Virginia-WiseNAIA | 44 | @ | BrevardD2 | 20 | | |
| Winston-Salem St | 7 | @ | CatawbaD2 | 21 | | |
| FindlayD2 | 25 | @ | Charleston WVD2 | 24 | | |
SIAC | Fort Valley StD2 | 9 | @ | Clark AtlantaD2 | 8 | | |
| BelhavenNAIA | 24 | @ | Concordia ALNAIA | 27 | | |
| WaldorfNAIA | 23 | @ | Dakota StNAIA | 31 | | |
CSFL | Peru StNAIA | 26 | @ | HaskellNAIA | 7 | | |
| Edward WatersNAIA | 14 | vs | Johnson C. SmithD2 | 19 | | Greenville SC |
| Kentucky StD2 | 21 | @ | Kentucky WesleyanD2 | 7 | | |
| LivingstoneD2 | 14 | @ | Lenoir-RhyneD2 | 17 | | |
| LaneD2 | 36 | @ | Lincoln MOD2 | 0 | | |
| ShepherdD2 | 28 | @ | MillersvilleD2 | 7 | | |
| Albany St GAD2 | 0 | @ | North Carolina CentralD2 | 20 | | |
| LindenwoodNAIA | 13 | vs | NW Oklahoma StNAIA | 14 | | Great Bend KS |
| West Liberty StD2 | 31 | @ | Seton HillNAIA | 14 | | |
GSC | Arkansas-MonticelloD2 | 15 | @ | Southern ArkansasD2 | 18 | | |
| TuskegeeD2 | 24 | @ | StillmanD2 | 6 | | |
| LangstonD2 | 20 | @ | Texas CollegeNAIA | 12 | | |
GLFC | Missouri-RollaD2 | 32 | @ | TiffinD2 | 58 | | |
| Southern VirginiaNAIA | 7 | @ | UrbanaNAIA | 52 | | |
| PresbyterianD2 | 10 | @ | West GeorgiaD2 | 0 | | |
RMAC | Fort LewisD2 | 23 | @ | Western New MexicoD2 | 7 | | |
| Fayetteville StD2 | 0 | @ | WingateD2 | 19 | | |