| 8/26/2006 | Winston-Salem St | 7 | @ | Catawba D2 | 21 | ||||
| 9/2/2006 | Winston-Salem St | 41 | @ | NC A&T | 14 | MEAC | |||
| 9/9/2006 | S Carolina St | 35 | @ | Winston-Salem St | 6 | MEAC | |||
| 9/23/2006 | Winston-Salem St | 21 | @ | Florida A&M | 25 | MEAC | |||
| 9/30/2006 | Coastal Car | 31 | @ | Winston-Salem St | 12 | ||||
| 10/7/2006 | Howard | 0 | @ | Winston-Salem St | 12 | MEAC | |||
| 10/14/2006 | Winston-Salem St | 6 | @ | Bethune-Cookman | 10 | MEAC | |||
| 10/21/2006 | Winston-Salem St | 38 | @ | Savannah St | 6 | ||||
| 10/28/2006 | Winston-Salem St | 3 | @ | Hampton | 13 | MEAC | |||
| 11/4/2006 | St Augustine's D2 | 16 | @ | Winston-Salem St | 26 | ||||
| 11/18/2006 | Winston-Salem St | 14 | @ | Norfolk St | 31 | MEAC |