| 9/2/2006 | S Carolina St | 21 | @ | Wofford | 28 | ||||
| 9/9/2006 | S Carolina St | 35 | @ | Winston-Salem St | 6 | MEAC | |||
| 9/16/2006 | Bethune-Cookman | 45 | @ | S Carolina St | 21 | MEAC | |||
| 9/23/2006 | S Carolina St | 14 | @ | Coastal Car | 33 | ||||
| 10/7/2006 | Norfolk St | 10 | @ | S Carolina St | 47 | MEAC | |||
| 10/14/2006 | S Carolina St | 28 | @ | Florida A&M | 21 | MEAC | |||
| 10/21/2006 | Hampton | 6 | @ | S Carolina St | 13 | MEAC | |||
| 10/28/2006 | S Carolina St | 9 | @ | Delaware St | 10 | MEAC | |||
| 11/4/2006 | Howard | 10 | @ | S Carolina St | 28 | MEAC | |||
| 11/11/2006 | S Carolina St | 41 | @ | Morgan St | 16 | MEAC | |||
| 11/18/2006 | S Carolina St | 41 | @ | NC A&T | 19 | MEAC | Charlotte NC |