| 9/3/2005 | Montana St | 10 | @ | Oklahoma St | 15 | ||||
| 9/8/2005 | Oklahoma St | 23 | @ | Florida Atlantic | 3 | Miami FL | |||
| 9/17/2005 | Arkansas St | 10 | @ | Oklahoma St | 20 | ||||
| 10/1/2005 | Colorado | 34 | @ | Oklahoma St | 0 | B12 | |||
| 10/8/2005 | Missouri | 38 | @ | Oklahoma St | 31 | B12 | |||
| 10/15/2005 | Oklahoma St | 23 | @ | Texas A&M | 62 | B12 | |||
| 10/22/2005 | Oklahoma St | 10 | @ | Iowa State | 37 | B12 | |||
| 10/29/2005 | #2 Texas | 47 | @ | Oklahoma St | 28 | B12 | |||
| 11/12/2005 | #15 Texas Tech | 17 | @ | Oklahoma St | 24 | B12 | |||
| 11/19/2005 | Oklahoma St | 34 | @ | Baylor | 44 | B12 | |||
| 11/26/2005 | Oklahoma St | 14 | @ | Oklahoma | 42 | B12 |