| 9/3/2020 | South Alabama (1-2) | 32 | at | Southern Miss | 21 | SBC | ||
| 9/19/2020 | Louisiana Tech (3-1,2-0) | 31 | at | Southern Miss | 30 | |||
| 9/26/2020 | Tulane (2-2) | 66 | at | Southern Miss | 24 | AAC | ||
| 10/3/2020 | Southern Miss | 41 | at | North Texas (1-3,0-2) | 31 | |||
| 10/17/2020 | Southern Miss | at | UTEP (3-2,0-1) | |||||
| 10/24/2020 | Southern Miss | at | Liberty (4-0) | at Ind | ||||
| 10/31/2020 | Rice | at | Southern Miss | |||||
| 11/7/2020 | North Alabama (0-1) | at | Southern Miss | BigS (1AA) | ||||
| 11/14/2020 | Southern Miss | at | Western Kentucky (1-3,1-1) | |||||
| 11/21/2020 | Texas-San Antonio (3-2,1-1) | at | Southern Miss | |||||
| 11/27/2020 | Southern Miss | at | UAB (3-1,1-0) |
| vs Southern Miss | vs Other Opponents | Southern Miss compared to OOs | |
| Record: | 3-1 | 18-16 | |
| Points Scored: | 40.00 | 26.74 | -13.26 |
| Points Allowed: | 29.00 | 28.74 | 0.26 |
| Margin: | 11.00 | -2.00 | -13.00 |
| Total Points: | 69.00 | 55.48 | 13.52 |