| 9/3/2020 | South Alabama | 32 | at | Southern Miss | 21 | SBC | ||
| Central Arkansas | 35 | at | UAB | 45 | SLC (1AA) | |||
| 9/5/2020 | Middle Tenn State | 0 | at | Army | 42 | @ Ind | ||
| Eastern Kentucky | 0 | at | Marshall | 59 | OVC (1AA) | |||
| Houston Baptist | 31 | at | North Texas | 57 | SLC (1AA) | |||
| Stephen F. Austin | 14 | at | UTEP | 24 | SLC (1AA) | |||
| 9/10/2020 | UAB | 14 | at | Miami-Florida | 31 | @ ACC | ||
| 9/12/2020 | UNC-Charlotte | 20 | at | Appalachian State | 35 | @ SBC | ||
| Western Kentucky | 21 | at | Louisville | 35 | @ ACC | |||
| UTEP | 3 | at | Texas | 59 | @ B12 | |||
| Texas-San Antonio | 51 | at | Texas State | 48 | @ SBC | |||
| 9/19/2020 | Appalachian State | 7 | at | Marshall | 17 | SBC | ||
| Troy | 47 | at | Middle Tenn State | 14 | SBC | |||
| SMU | 65 | at | North Texas | 35 | AAC | |||
| Louisiana Tech | 31 | at | Southern Miss | 30 | ||||
| Stephen F. Austin | 10 | at | Texas-San Antonio | 24 | SLC (1AA) | |||
| Abilene Christian | 13 | at | UTEP | 17 | SLC (1AA) | |||
| Liberty | 30 | at | Western Kentucky | 24 | Ind | |||
| 9/24/2020 | UAB | 42 | at | South Alabama | 10 | @ SBC | ||
| 9/25/2020 | Middle Tenn State | 35 | at | Texas-San Antonio | 37 | |||
| 9/26/2020 | Florida Intl | 34 | at | Liberty | 36 | @ Ind | ||
| Houston Baptist | 38 | at | Louisiana Tech | 66 | SLC (1AA) | |||
| Tulane | 66 | at | Southern Miss | 24 | AAC | |||
| UTEP | 31 | at | UL Monroe | 6 | @ SBC | |||
| 10/2/2020 | Louisiana Tech | 14 | at | BYU | 45 | @ Ind | ||
| 10/3/2020 | UNC-Charlotte | 17 | at | Florida Atlantic | 21 | |||
| Western Kentucky | 20 | at | Middle Tenn State | 17 | ||||
| Southern Miss | 41 | at | North Texas | 31 | ||||
| Texas-San Antonio | 13 | at | UAB | 21 | ||||
| 10/10/2020 | Texas-San Antonio | 20 | at | BYU | 27 | @ Ind | ||
| Middle Tenn State | 31 | at | Florida Intl | 28 | ||||
| UTEP | 17 | at | Louisiana Tech | 21 | ||||
| UNC-Charlotte | 49 | at | North Texas | 21 | ||||
| Marshall | 38 | at | Western Kentucky | 14 | ||||
| 10/17/2020 | Florida Intl | at | UNC-Charlotte | |||||
| Marshall | at | Louisiana Tech | ||||||
| North Texas | at | Middle Tenn State | ||||||
| Western Kentucky | at | UAB | ||||||
| Army | at | Texas-San Antonio | Ind | |||||
| Southern Miss | at | UTEP | ||||||
| 10/23/2020 | Jacksonville State | at | Florida Intl | OVC (1AA) | ||||
| UL Lafayette | at | UAB | SBC | |||||
| 10/24/2020 | UTEP | at | UNC-Charlotte | |||||
| Southern Miss | at | Liberty | @ Ind | |||||
| Florida Atlantic | at | Marshall | ||||||
| Middle Tenn State | at | Rice | ||||||
| Louisiana Tech | at | Texas-San Antonio | ||||||
| Chattanooga | at | Western Kentucky | SoCon (1AA) | |||||
| 10/30/2020 | Marshall | at | Florida Intl | |||||
| 10/31/2020 | Western Kentucky | at | BYU | @ Ind | ||||
| UNC-Charlotte | at | Duke | @ ACC | |||||
| Texas-San Antonio | at | Florida Atlantic | ||||||
| UAB | at | Louisiana Tech | ||||||
| Rice | at | Southern Miss | ||||||
| North Texas | at | UTEP | ||||||
| 11/7/2020 | Western Kentucky | at | Florida Atlantic | |||||
| UNC-Charlotte | at | Middle Tenn State | ||||||
| Louisiana Tech | at | North Texas | ||||||
| Texas-San Antonio | at | Rice | ||||||
| North Alabama | at | Southern Miss | BigS (1AA) | |||||
| Florida Intl | at | UTEP | ||||||
| 11/13/2020 | Florida Atlantic | at | Florida Intl | |||||
| 11/14/2020 | Rice | at | Louisiana Tech | |||||
| Middle Tenn State | at | Marshall | ||||||
| North Texas | at | UAB | ||||||
| UTEP | at | Texas-San Antonio | ||||||
| Southern Miss | at | Western Kentucky | ||||||
| 11/21/2020 | UL Monroe | at | Louisiana Tech | Shreveport, LA | SBC | |||
| UNC-Charlotte | at | Marshall | ||||||
| Rice | at | North Texas | ||||||
| Texas-San Antonio | at | Southern Miss | ||||||
| Middle Tenn State | at | Troy | @ SBC | |||||
| UAB | at | UTEP | ||||||
| Florida Intl | at | Western Kentucky | ||||||
| 11/27/2020 | Southern Miss | at | UAB | |||||
| 11/28/2020 | Western Kentucky | at | UNC-Charlotte | |||||
| Louisiana Tech | at | Florida Intl | ||||||
| Florida Atlantic | at | Middle Tenn State | ||||||
| UTEP | at | Rice | ||||||
| North Texas | at | Texas-San Antonio | ||||||
| 12/5/2020 | Florida Atlantic | at | Georgia Southern | @ SBC |