| 9/12/2020 | Duke | 13 | at | Notre Dame (3-0,2-0) | 27 | |||
| 9/19/2020 | Boston College (3-1,2-1) | 26 | at | Duke | 6 | |||
| 9/26/2020 | Duke | 20 | at | Virginia (1-2,1-2) | 38 | |||
| 10/3/2020 | Virginia Tech (2-1,2-1) | 38 | at | Duke | 31 | |||
| 10/10/2020 | Duke | 38 | at | Syracuse (1-3,1-3) | 24 | |||
| 10/17/2020 | Duke | at | North Carolina State (3-1,3-1) | |||||
| 10/31/2020 | UNC-Charlotte (1-2) | at | Duke | CUSA | ||||
| 11/7/2020 | North Carolina (3-0,3-0) | at | Duke | |||||
| 11/21/2020 | Wake Forest (1-2,0-2) | at | Duke | |||||
| 11/28/2020 | Duke | at | Georgia Tech (2-2,2-1) | |||||
| 12/5/2020 | Florida State (1-3,0-3) | at | Duke |
| vs Duke | vs Other Opponents | Duke compared to OOs | |
| Record: | 4-1 | 17-16 | |
| Points Scored: | 30.60 | 30.55 | -0.05 |
| Points Allowed: | 21.60 | 29.61 | -8.01 |
| Margin: | 9.00 | 0.94 | -8.06 |
| Total Points: | 52.20 | 60.16 | -7.96 |