Big5
15 Oct 2020 21:55:14
| 9/10/2020 | UAB | 14 | at | Miami-Florida | 31 | | | CUSA |
| 9/12/2020 | Georgia Tech | 16 | at | Florida State | 13 | | | |
| Western Kentucky | 21 | at | Louisville | 35 | | | CUSA |
| Syracuse | 6 | at | North Carolina | 31 | | | |
| Duke | 13 | at | Notre Dame | 27 | | | |
| Austin Peay | 0 | at | Pittsburgh | 55 | | | OVC (1AA) |
| Clemson | 37 | at | Wake Forest | 13 | | | |
| 9/19/2020 | The Citadel | 0 | at | Clemson | 49 | | | SoCon (1AA) |
| Boston College | 26 | at | Duke | 6 | | | |
| UCF | 49 | at | Georgia Tech | 21 | | | AAC |
| Miami-Florida | 47 | at | Louisville | 34 | | | |
| Wake Forest | 42 | at | North Carolina State | 45 | | | |
| South Florida | 0 | at | Notre Dame | 52 | | | AAC |
| Syracuse | 10 | at | Pittsburgh | 21 | | | |
| 9/26/2020 | Texas State | 21 | at | Boston College | 24 | | | SBC |
| Florida State | 10 | at | Miami-Florida | 52 | | | |
| Louisville | 20 | at | Pittsburgh | 23 | | | |
| Georgia Tech | 20 | at | Syracuse | 37 | | | |
| Duke | 20 | at | Virginia | 38 | | | |
| North Carolina State | 24 | at | Virginia Tech | 45 | | | |
| 10/2/2020 | Campbell | 14 | at | Wake Forest | 66 | | | BigS (1AA) |
| 10/3/2020 | North Carolina | 26 | at | Boston College | 22 | | | |
| Virginia | 23 | at | Clemson | 41 | | | |
| Virginia Tech | 38 | at | Duke | 31 | | | |
| Jacksonville State | 24 | at | Florida State | 41 | | | OVC (1AA) |
| North Carolina State | 30 | at | Pittsburgh | 29 | | | |
| 10/9/2020 | Louisville | 27 | at | Georgia Tech | 46 | | | |
| 10/10/2020 | Pittsburgh | 30 | at | Boston College | 31 | | | |
| Miami-Florida | 17 | at | Clemson | 42 | | | |
| Virginia Tech | 45 | at | North Carolina | 56 | | | |
| Florida State | 26 | at | Notre Dame | 42 | | | |
| Duke | 38 | at | Syracuse | 24 | | | |
| North Carolina State | 38 | at | Virginia | 21 | | | |
| 10/17/2020 | North Carolina | | at | Florida State | | | | |
| Clemson | | at | Georgia Tech | | | | |
| Pittsburgh | | at | Miami-Florida | | | | |
| Duke | | at | North Carolina State | | | | |
| Louisville | | at | Notre Dame | | | | |
| Liberty | | at | Syracuse | | | | Ind |
| Boston College | | at | Virginia Tech | | | | |
| Virginia | | at | Wake Forest | | | | |
| 10/24/2020 | Georgia Tech | | at | Boston College | | | | |
| Syracuse | | at | Clemson | | | | |
| Florida State | | at | Louisville | | | | |
| Virginia | | at | Miami-Florida | | | | |
| North Carolina State | | at | North Carolina | | | | |
| Notre Dame | | at | Pittsburgh | | | | |
| Virginia Tech | | at | Wake Forest | | | | |
| 10/31/2020 | Boston College | | at | Clemson | | | | |
| UNC-Charlotte | | at | Duke | | | | CUSA |
| Notre Dame | | at | Georgia Tech | | | | |
| Virginia Tech | | at | Louisville | | | | |
| Wake Forest | | at | Syracuse | | | | |
| North Carolina | | at | Virginia | | | | |
| 11/6/2020 | Miami-Florida | | at | North Carolina State | | | | |
| 11/7/2020 | North Carolina | | at | Duke | | | | |
| Pittsburgh | | at | Florida State | | | | |
| Clemson | | at | Notre Dame | | | | |
| Boston College | | at | Syracuse | | | | |
| Louisville | | at | Virginia | | | | |
| Liberty | | at | Virginia Tech | | | | Ind |
| 11/14/2020 | Notre Dame | | at | Boston College | | | | |
| Pittsburgh | | at | Georgia Tech | | | | |
| Florida State | | at | North Carolina State | | | | |
| Wake Forest | | at | North Carolina | | | | |
| Miami-Florida | | at | Virginia Tech | | | | |
| 11/20/2020 | Syracuse | | at | Louisville | | | | |
| 11/21/2020 | Wake Forest | | at | Duke | | | | |
| Clemson | | at | Florida State | | | | |
| Georgia Tech | | at | Miami-Florida | | | | |
| Liberty | | at | North Carolina State | | | | Ind |
| Virginia Tech | | at | Pittsburgh | | | | |
| Abilene Christian | | at | Virginia | | | | SLC (1AA) |
| 11/27/2020 | Louisville | | at | Boston College | | | | |
| Notre Dame | | at | North Carolina | | | | |
| 11/28/2020 | Pittsburgh | | at | Clemson | | | | |
| Virginia | | at | Florida State | | | | |
| Duke | | at | Georgia Tech | | | | |
| North Carolina State | | at | Syracuse | | | | |
| Miami-Florida | | at | Wake Forest | | | | |
| 12/5/2020 | Florida State | | at | Duke | | | | |
| Wake Forest | | at | Louisville | | | | |
| North Carolina | | at | Miami-Florida | | | | |
| Georgia Tech | | at | North Carolina State | | | | |
| Syracuse | | at | Notre Dame | | | | |
| Boston College | | at | Virginia | | | | |
| Clemson | | at | Virginia Tech | | | | |
| 12/11/2020 | Western Carolina | | at | North Carolina | | | | SoCon (1AA) |
| 12/12/2020 | Virginia | | at | Virginia Tech | | | | |
| Notre Dame | | at | Wake Forest | | | | |