| 8/31/2024 | Indiana State (4-8) | 0 | at | Purdue | 49 | MVC (1AA) | ||
| 9/14/2024 | Notre Dame (12-1) | 66 | at | Purdue | 7 | ND | ||
| 9/21/2024 | Purdue | 21 | at | Oregon State (5-7) | 38 | at P12 | ||
| 9/28/2024 | Nebraska (6-6,3-6) | 28 | at | Purdue | 10 | |||
| 10/5/2024 | Purdue | 6 | at | Wisconsin (5-7,3-6) | 52 | |||
| 10/12/2024 | Purdue | 49 | at | Illinois (9-3,6-3) | 50 | |||
| 10/18/2024 | Oregon (13-0,10-0) | 35 | at | Purdue | 0 | |||
| 11/2/2024 | Northwestern (4-8,2-7) | 26 | at | Purdue | 20 | OT | ||
| 11/9/2024 | Purdue | 0 | at | Ohio State (11-2,7-2) | 45 | |||
| 11/16/2024 | Penn State (12-2,8-2) | 49 | at | Purdue | 10 | |||
| 11/22/2024 | Purdue | 17 | at | Michigan State (5-7,3-6) | 24 | |||
| 11/30/2024 | Purdue | 0 | at | Indiana (11-2,8-1) | 66 |
| vs Purdue | vs Other Opponents | Purdue compared to OOs | |
| Record: | 11-1 | 86-52 | |
| Points Scored: | 39.92 | 27.87 | -12.05 |
| Points Allowed: | 15.75 | 21.25 | -5.50 |
| Margin: | 24.17 | 6.62 | -17.55 |
| Total Points: | 55.67 | 49.12 | 6.55 |