| 8/31/2024 | North Dakota (5-7) | 3 | at | Iowa State | 21 | MVC (1AA) | ||
| 9/7/2024 | Iowa State | 20 | at | Iowa (8-4) | 19 | at B10 | ||
| 9/21/2024 | Arkansas State (7-5) | 7 | at | Iowa State | 52 | SBC | ||
| 9/28/2024 | Iowa State | 20 | at | Houston (4-8,3-6) | 0 | |||
| 10/5/2024 | Baylor (8-4,6-4) | 21 | at | Iowa State | 43 | |||
| 10/12/2024 | Iowa State | 28 | at | West Virginia (6-6,5-4) | 16 | |||
| 10/19/2024 | UCF (4-8,2-7) | 35 | at | Iowa State | 38 | |||
| 11/2/2024 | Texas Tech (8-4,6-3) | 23 | at | Iowa State | 22 | |||
| 11/9/2024 | Iowa State | 36 | vs | Kansas (5-7,4-5) | 45 | Kansas City MO | ||
| 11/16/2024 | Cincinnati (5-7,3-6) | 17 | at | Iowa State | 34 | |||
| 11/23/2024 | Iowa State | 31 | at | Utah (5-7,3-7) | 28 | |||
| 11/30/2024 | Kansas State (8-4,6-4) | 21 | at | Iowa State | 29 | |||
| 12/7/2024 | Iowa State | 19 | vs | Arizona State (11-2,8-2) | 45 | B12 Championship - Dallas TX | ||
| 12/28/2024 | Iowa State | vs | Miami-Florida (10-2) | Pop-Tarts Bowl - Orlando FL | vs ACC |
| vs Iowa State | vs Other Opponents | Iowa State compared to OOs | |
| Record: | 3-10 | 91-65 | |
| Points Scored: | 21.54 | 30.36 | 8.82 |
| Points Allowed: | 30.23 | 25.26 | 4.97 |
| Margin: | -8.69 | 5.10 | 13.79 |
| Total Points: | 51.77 | 55.62 | -3.85 |