| 9/2/2023 | Greensboro (2-8) | 21 | at | Guilford | 36 | USASC | ||
| 9/9/2023 | Guilford | 39 | at | Methodist (2-8) | 21 | at USASC | ||
| 9/16/2023 | Guilford | 14 | at | Huntingdon AL (8-2) | 40 | at USASC | ||
| 9/30/2023 | Randolph-Macon (13-1,7-0) | 70 | at | Guilford | 14 | |||
| 10/7/2023 | Guilford | 25 | at | Washington and Lee (8-3,6-1) | 48 | |||
| 10/14/2023 | Shenandoah (5-5,3-4) | 31 | at | Guilford | 20 | |||
| 10/21/2023 | Guilford | 0 | at | Ferrum (3-7,1-6) | 28 | |||
| 10/28/2023 | Hampden-Sydney (6-4,4-3) | 42 | at | Guilford | 21 | |||
| 11/4/2023 | Averett (5-5,2-5) | 34 | at | Guilford | 13 | |||
| 11/11/2023 | Guilford | 15 | at | Bridgewater VA (7-4,5-2) | 47 |
| vs Guilford | vs Other Opponents | Guilford compared to OOs | |
| Record: | 8-2 | 51-45 | |
| Points Scored: | 38.20 | 28.11 | -10.09 |
| Points Allowed: | 19.70 | 26.47 | -6.77 |
| Margin: | 18.50 | 1.64 | -16.86 |
| Total Points: | 57.90 | 54.58 | 3.32 |