| 9/2/2023 | Austin Peay (9-3) | 23 | at | Southern Illinois | 49 | ASUN | ||
| 9/9/2023 | Southern Illinois | 14 | at | Northern Illinois (7-6) | 11 | at MAC | ||
| 9/16/2023 | Southern Illinois | 26 | at | SE Missouri State (4-7) | 25 | at BigS | ||
| 9/30/2023 | Missouri State (4-7,3-5) | 20 | at | Southern Illinois | 33 | |||
| 10/7/2023 | Southern Illinois | 3 | at | Youngstown State (8-5,5-3) | 31 | |||
| 10/14/2023 | Southern Illinois | 27 | at | Murray State (2-9,1-7) | 6 | |||
| 10/21/2023 | South Dakota State (15-0,8-0) | 17 | at | Southern Illinois | 10 | |||
| 10/28/2023 | Southern Illinois | 63 | at | Western Illinois (0-11,0-8) | 0 | |||
| 11/4/2023 | South Dakota (10-3,7-2) | 14 | at | Southern Illinois | 7 | |||
| 11/11/2023 | Southern Illinois | 10 | at | North Dakota State (11-4,6-3) | 34 | |||
| 11/18/2023 | Indiana State (1-10,1-7) | 9 | at | Southern Illinois | 38 | |||
| 11/25/2023 | Nicholls State (6-5) | 0 | at | Southern Illinois | 35 | FCS Championship - First Round | SLC | |
| 12/2/2023 | Southern Illinois | 17 | at | Idaho (9-4) | 20 | OT | FCS Championship - Second Round | at BSky |
| vs Southern Illinois | vs Other Opponents | Southern Illinois compared to OOs | |
| Record: | 5-8 | 81-66 | |
| Points Scored: | 16.15 | 28.31 | 12.16 |
| Points Allowed: | 25.54 | 25.04 | 0.50 |
| Margin: | -9.39 | 3.27 | 12.66 |
| Total Points: | 41.69 | 53.35 | -11.66 |