| 8/31/2023 | Sacramento State (8-5) | 38 | at | Nicholls State | 24 | BSky | ||
| 9/9/2023 | Nicholls State | 6 | at | TCU (5-7) | 41 | at B12 | ||
| 9/23/2023 | Nicholls State | 7 | at | Tulane (11-3) | 36 | at AAC | ||
| 9/30/2023 | Nicholls State | 31 | at | McNeese State (0-10,0-6) | 10 | |||
| 10/7/2023 | Houston Christian (5-5,3-3) | 7 | at | Nicholls State | 38 | |||
| 10/14/2023 | Northwestern State (0-6,0-2) | at | Nicholls State | CCD | ||||
| 10/21/2023 | Nicholls State | 27 | at | Texas A&M-Commerce (1-9,1-5) | 7 | |||
| 10/28/2023 | SE Missouri State (4-7) | 35 | at | Nicholls State | 31 | BigS | ||
| 11/4/2023 | Nicholls State | 45 | at | Incarnate Word (8-2,5-1) | 32 | |||
| 11/11/2023 | Lamar (6-5,5-2) | 24 | at | Nicholls State | 37 | |||
| 11/16/2023 | Nicholls State | 21 | at | Southeastern Louisiana (3-8,3-4) | 16 | |||
| 11/25/2023 | Nicholls State | 0 | at | Southern Illinois (8-5) | 35 | FCS Championship - First Round | at MVC |
| vs Nicholls State | vs Other Opponents | Nicholls State compared to OOs | |
| Record: | 5-6 | 54-66 | |
| Points Scored: | 25.55 | 25.61 | 0.06 |
| Points Allowed: | 24.27 | 26.72 | -2.45 |
| Margin: | 1.28 | -1.11 | -2.39 |
| Total Points: | 49.82 | 52.33 | -2.51 |