| 8/31/2023 | South Dakota (10-3) | 10 | at | Missouri | 35 | MVC (1AA) | ||
| 9/9/2023 | Middle Tenn State (4-8) | 19 | at | Missouri | 23 | CUSA | ||
| 9/16/2023 | Kansas State (9-4) | 27 | at | Missouri | 30 | B12 | ||
| 9/23/2023 | Memphis (10-3) | 27 | vs | Missouri | 34 | St Louis MO | AAC | |
| 9/30/2023 | Missouri | 38 | at | Vanderbilt (2-10,0-8) | 21 | |||
| 10/7/2023 | LSU (10-3,6-2) | 49 | at | Missouri | 39 | |||
| 10/14/2023 | Missouri | 38 | at | Kentucky (7-6,3-5) | 21 | |||
| 10/21/2023 | South Carolina (5-7,3-5) | 12 | at | Missouri | 34 | |||
| 11/4/2023 | Missouri | 21 | at | Georgia (13-1,8-1) | 30 | |||
| 11/11/2023 | Tennessee (9-4,4-4) | 7 | at | Missouri | 36 | |||
| 11/18/2023 | Florida (5-7,3-5) | 31 | at | Missouri | 33 | |||
| 11/24/2023 | Missouri | 48 | at | Arkansas (4-8,1-7) | 14 | |||
| 12/29/2023 | Missouri | 14 | vs | Ohio State (11-2) | 3 | Cotton Bowl - Arlington TX | vs B10 |
| vs Missouri | vs Other Opponents | Missouri compared to OOs | |
| Record: | 2-11 | 97-55 | |
| Points Scored: | 20.85 | 32.33 | 11.48 |
| Points Allowed: | 32.54 | 23.26 | 9.28 |
| Margin: | -11.69 | 9.07 | 20.76 |
| Total Points: | 53.39 | 55.59 | -2.20 |