| 9/1/2023 | Central Michigan (5-7) | 7 | at | Michigan State | 31 | MAC | ||
| 9/9/2023 | Richmond (9-4) | 14 | at | Michigan State | 45 | CAAF (1AA) | ||
| 9/16/2023 | Washington (14-1) | 41 | at | Michigan State | 7 | P12 | ||
| 9/23/2023 | Maryland (8-5,4-5) | 31 | at | Michigan State | 9 | |||
| 9/30/2023 | Michigan State | 16 | at | Iowa (10-4,7-3) | 26 | |||
| 10/14/2023 | Michigan State | 24 | at | Rutgers (7-6,3-6) | 27 | |||
| 10/21/2023 | Michigan (15-0,10-0) | 49 | at | Michigan State | 0 | |||
| 10/28/2023 | Michigan State | 12 | at | Minnesota (6-7,3-6) | 27 | |||
| 11/4/2023 | Nebraska (5-7,3-6) | 17 | at | Michigan State | 20 | |||
| 11/11/2023 | Michigan State | 3 | at | Ohio State (11-2,8-1) | 38 | |||
| 11/18/2023 | Michigan State | 24 | at | Indiana (3-9,1-8) | 21 | |||
| 11/24/2023 | Penn State (10-3,7-2) | 42 | vs | Michigan State | 0 | Detroit MI |
| vs Michigan State | vs Other Opponents | Michigan State compared to OOs | |
| Record: | 8-4 | 95-51 | |
| Points Scored: | 28.33 | 26.77 | -1.56 |
| Points Allowed: | 15.92 | 20.81 | -4.89 |
| Margin: | 12.41 | 5.96 | -6.45 |
| Total Points: | 44.25 | 47.58 | -3.33 |