| 9/7/2019 | Case Western Reserve (9-2) | 37 | at | Rochester | 6 | TPAC | ||
| 9/14/2019 | Rochester | 3 | at | Endicott (9-2) | 28 | at CCF | ||
| 9/21/2019 | Alfred State (3-6) | 27 | at | Rochester | 21 | ECFC | ||
| 9/28/2019 | Rochester | 13 | at | Alfred (5-5) | 56 | at E8 | ||
| 10/5/2019 | Rochester | 0 | at | Rensselaer (6-5,2-3) | 38 | |||
| 10/12/2019 | Union NY (11-1,5-0) | 47 | at | Rochester | 19 | |||
| 10/19/2019 | Rochester | 7 | at | Buffalo State (1-9) | 13 | at E8 | ||
| 10/26/2019 | Ithaca (8-3,3-2) | 59 | at | Rochester | 0 | |||
| 11/9/2019 | Rochester | 19 | at | St Lawrence (5-5,2-3) | 51 | |||
| 11/16/2019 | Hobart (9-2,3-2) | 51 | at | Rochester | 20 |
| vs Rochester | vs Other Opponents | Rochester compared to OOs | |
| Record: | 10-0 | 56-40 | |
| Points Scored: | 40.70 | 28.56 | -12.14 |
| Points Allowed: | 10.80 | 23.67 | -12.87 |
| Margin: | 29.90 | 4.89 | -25.01 |
| Total Points: | 51.50 | 52.23 | -0.73 |