| 9/7/2019 | Brockport State | 7 | at | Hobart | 33 | E8 | ||
| Case Western Reserve | 37 | at | Rochester | 6 | TPAC | |||
| Allegheny | 14 | at | Rensselaer | 52 | NCA | |||
| Ithaca | 66 | at | St Vincent | 28 | @ TPAC | |||
| Westfield State | 7 | at | Union NY | 42 | MSCAC | |||
| St Lawrence | 14 | at | Utica | 40 | @ E8 | |||
| 9/14/2019 | Union NY | 54 | at | Anna Maria | 7 | @ ECFC | ||
| Rochester | 3 | at | Endicott | 28 | @ CCF | |||
| Hobart | 38 | at | Morrisville | 24 | @ E8 | |||
| St Lawrence | 24 | at | Norwich | 30 | @ NEWMAC | |||
| Rensselaer | 3 | at | Worcester Polytechnic | 6 | @ NEWMAC | |||
| 9/20/2019 | Morrisville | 22 | at | St Lawrence | 32 | E8 | ||
| 9/21/2019 | Rowan | 17 | at | Hobart | 20 | NJAC | ||
| Alfred | 9 | at | Ithaca | 27 | E8 | |||
| Alfred State | 27 | at | Rochester | 21 | ECFC | |||
| Utica | 33 | at | Rensselaer | 35 | E8 | |||
| Springfield | 17 | at | Union NY | 27 | NEWMAC | |||
| 9/28/2019 | Rochester | 13 | at | Alfred | 56 | @ E8 | ||
| Montclair State | 3 | at | Hobart | 16 | NJAC | |||
| St John Fisher | 35 | at | Ithaca | 38 | E8 | |||
| Anna Maria | 0 | at | Rensselaer | 38 | ECFC | |||
| Hartwick | 0 | at | St Lawrence | 33 | E8 | |||
| 10/5/2019 | Rochester | 0 | at | Rensselaer | 38 | |||
| Ithaca | 59 | at | St Lawrence | 20 | ||||
| Hobart | 7 | at | Union NY | 23 | ||||
| 10/12/2019 | Rensselaer | 27 | at | Hobart | 41 | |||
| Buffalo State | 14 | at | Ithaca | 48 | E8 | |||
| Union NY | 47 | at | Rochester | 19 | ||||
| 10/19/2019 | Rochester | 7 | at | Buffalo State | 13 | @ E8 | ||
| Hobart | 0 | at | Ithaca | 34 | ||||
| St Lawrence | 17 | at | Union NY | 38 | ||||
| 10/26/2019 | Union NY | 28 | at | Buffalo State | 14 | @ E8 | ||
| Ithaca | 59 | at | Rochester | 0 | ||||
| Rensselaer | 21 | at | St Lawrence | 35 | ||||
| 11/2/2019 | St Lawrence | 3 | at | Hobart | 35 | |||
| Union NY | 31 | at | Ithaca | 21 | ||||
| Buffalo State | 26 | at | Rensselaer | 28 | E8 | |||
| 11/9/2019 | Buffalo State | 23 | at | Hobart | 40 | E8 | ||
| Ithaca | 12 | at | Rensselaer | 38 | ||||
| Rochester | 19 | at | St Lawrence | 51 | ||||
| Utica | 7 | at | Union NY | 13 | E8 | |||
| 11/16/2019 | St Lawrence | 31 | at | Buffalo State | 26 | @ E8 | ||
| Ithaca | 32 | vs | Cortland | 20 | East Rutherford NJ | vs E8 | ||
| Hobart | 51 | at | Rochester | 20 | ||||
| Rensselaer | 0 | at | Union NY | 33 | ||||
| 11/23/2019 | Hobart | 30 | at | Cortland | 10 | @ E8 | ||
| Rensselaer | 38 | at | Grove City | 41 | @ TPAC | |||
| Washington & Jefferson | 20 | at | Ithaca | 17 | TPAC | |||
| Case Western Reserve | 21 | at | Union NY | 24 | D3 Playoff round 1 | TPAC | ||
| 11/30/2019 | Union NY | 41 | at | Salisbury | 62 | D3 Playoff round 2 | @ NJAC |