| 9/5/2019 | Northwestern Oklahoma State | 21 | at | East Central (3-8,3-8) | 13 | | | |
| 9/14/2019 | Southeastern Oklahoma State (1-10,1-10) | 24 | at | Northwestern Oklahoma State | 15 | | | |
| 9/21/2019 | Northwestern Oklahoma State | 11 | at | Ouachita (11-1,11-0) | 31 | | | |
| 9/28/2019 | Arkansas-Monticello (5-6,5-6) | 0 | at | Northwestern Oklahoma State | 28 | | | |
| 10/5/2019 | Northwestern Oklahoma State | 7 | at | Henderson State (9-3,9-2) | 47 | | | |
| 10/12/2019 | Southern Arkansas (8-4,8-3) | 40 | at | Northwestern Oklahoma State | 7 | | | |
| 10/19/2019 | Northwestern Oklahoma State | 14 | at | Arkansas Tech (3-8,3-8) | 21 | | | |
| 10/26/2019 | Harding (10-2,10-1) | 47 | at | Northwestern Oklahoma State | 13 | | | |
| 11/2/2019 | Oklahoma Baptist (7-4,7-4) | 34 | at | Northwestern Oklahoma State | 25 | | | |
| 11/9/2019 | Northwestern Oklahoma State | 35 | at | Southern Nazarene (2-9,2-9) | 21 | | | |
| 11/16/2019 | Southwestern Oklahoma State (3-8,3-8) | 16 | at | Northwestern Oklahoma State | 28 | | | |