| 8/25/2018 | Mayville State | 20 | at | Montana State-Northern (1-10) | 49 | at Front | ||
| 9/1/2018 | Mayville State | 20 | at | Midland U. (7-4) | 56 | at GPAC | ||
| 9/8/2018 | St Scholastica (6-4) | 29 | at | Mayville State | 33 | UMWAC (D3) | ||
| 9/22/2018 | Mayville State | 0 | at | Valley City State (6-4,5-2) | 37 | |||
| 9/29/2018 | Waldorf (5-5,5-2) | 55 | at | Mayville State | 14 | |||
| 10/6/2018 | Mayville State | 37 | at | Presentation (4-6,3-4) | 47 | |||
| 10/13/2018 | Mayville State | 14 | at | Dickinson State (9-3,6-1) | 40 | |||
| 10/20/2018 | Dakota State (3-8,2-5) | 28 | at | Mayville State | 19 | |||
| 10/27/2018 | Valley City State (6-4,5-2) | 36 | at | Mayville State | 14 | |||
| 11/3/2018 | Mayville State | 22 | at | Waldorf (5-5,5-2) | 41 |
| vs Mayville State | vs Other Opponents | Mayville State compared to OOs | |
| Record: | 9-1 | 39-52 | |
| Points Scored: | 41.80 | 31.12 | -10.68 |
| Points Allowed: | 19.30 | 33.99 | -14.69 |
| Margin: | 22.50 | -2.87 | -25.37 |
| Total Points: | 61.10 | 65.11 | -4.01 |