| 8/23/2018 | Dakota State | 27 | at | Dakota Wesleyan | 18 | @ GPAC | ||
| 8/25/2018 | Waldorf | 13 | at | Briar Cliff | 40 | @ GPAC | ||
| Valley City State | 26 | at | Jamestown | 28 | @ GPAC | |||
| Mayville State | 20 | at | Montana State-Northern | 49 | @ Front | |||
| Presentation | 46 | at | Trinity International | 53 | @ MSFA | |||
| 9/1/2018 | Saint Ambrose | 49 | at | Dakota State | 27 | MSFA | ||
| Jamestown | 0 | at | Dickinson State | 51 | GPAC | |||
| Mayville State | 20 | at | Midland U. | 56 | @ GPAC | |||
| Dakota Wesleyan | 64 | at | Presentation | 37 | GPAC | |||
| Northwestern IA | 28 | at | Valley City State | 10 | GPAC | |||
| Dordt | 61 | at | Waldorf | 40 | GPAC | |||
| 9/6/2018 | Briar Cliff | 49 | at | Dakota State | 20 | GPAC | ||
| 9/8/2018 | St Scholastica | 29 | at | Mayville State | 33 | UMWAC (D3) | ||
| Crown | 14 | at | Presentation | 42 | UMWAC (D3) | |||
| Dickinson State | 10 | at | Rocky Mountain | 21 | @ Front | |||
| Waldorf | 34 | at | Stetson | 63 | @ Pio (1AA) | |||
| Minnesota-Morris | 0 | at | Valley City State | 48 | UMWAC (D3) | |||
| 9/15/2018 | Dickinson State | 35 | at | Wisconsin-La Crosse | 17 | @ WIAC (D3) | ||
| Dakota State | 28 | at | Wisconsin-Stevens Point | 51 | @ WIAC (D3) | |||
| 9/22/2018 | Presentation | 0 | at | Dickinson State | 59 | |||
| Mayville State | 0 | at | Valley City State | 37 | ||||
| Dakota State | 35 | at | Waldorf | 50 | ||||
| 9/29/2018 | Dickinson State | 33 | at | Dakota State | 27 | |||
| Waldorf | 55 | at | Mayville State | 14 | ||||
| Presentation | 37 | at | Valley City State | 30 | ||||
| 10/6/2018 | Valley City State | 27 | at | Dakota State | 16 | |||
| Mayville State | 37 | at | Presentation | 47 | ||||
| Dickinson State | 22 | at | Waldorf | 23 | ||||
| 10/13/2018 | Presentation | 28 | at | Dakota State | 44 | |||
| Mayville State | 14 | at | Dickinson State | 40 | ||||
| Waldorf | 21 | at | Valley City State | 24 | ||||
| 10/20/2018 | Valley City State | 26 | at | Dickinson State | 31 | |||
| Dakota State | 28 | at | Mayville State | 19 | ||||
| Presentation | 44 | at | Waldorf | 38 | ||||
| 10/27/2018 | Waldorf | 51 | at | Dakota State | 37 | |||
| Valley City State | 36 | at | Mayville State | 14 | ||||
| Dickinson State | 48 | at | Presentation | 24 | ||||
| 11/3/2018 | Dakota State | 25 | at | Dickinson State | 41 | |||
| Valley City State | 49 | at | Presentation | 21 | ||||
| Mayville State | 22 | at | Waldorf | 41 | ||||
| 11/17/2018 | Dickinson State | 14 | at | Northwestern IA | 6 | NAIA Playoff Round 1 | @ GPAC | |
| 11/24/2018 | Dickinson State | 40 | at | Kansas Wesleyan | 43 | @ KCAC |