| 9/1/2018 | Denison (8-3) | 21 | at | Southwestern Texas | 42 | NCA | ||
| 9/8/2018 | Southwestern Texas | 37 | at | McMurry (2-8,2-7) | 6 | |||
| 9/15/2018 | Southwestern Texas | 21 | at | East Texas Baptist (6-4,6-3) | 51 | |||
| 9/22/2018 | Louisiana College (5-5,5-4) | 21 | at | Southwestern Texas | 19 | |||
| 9/29/2018 | Southwestern Texas | 7 | at | Mary Hardin-Baylor (15-0,10-0) | 77 | |||
| 10/6/2018 | Southwestern Texas | 55 | at | Sul Ross State (1-9,1-8) | 7 | |||
| 10/13/2018 | Belhaven (2-8,2-7) | 10 | at | Southwestern Texas | 21 | |||
| 10/27/2018 | Hardin-Simmons (9-2,8-2) | 49 | at | Southwestern Texas | 35 | |||
| 11/3/2018 | Southwestern Texas | 54 | at | Howard Payne (1-9,1-8) | 17 | |||
| 11/10/2018 | Texas Lutheran (7-3,6-3) | 35 | at | Southwestern Texas | 59 |
| vs Southwestern Texas | vs Other Opponents | Southwestern Texas compared to OOs | |
| Record: | 4-6 | 52-45 | |
| Points Scored: | 29.40 | 32.02 | 2.62 |
| Points Allowed: | 35.00 | 30.27 | 4.73 |
| Margin: | -5.60 | 1.75 | 7.35 |
| Total Points: | 64.40 | 62.29 | 2.11 |