| 9/1/2018 | Albion (7-3) | 59 | at | Defiance | 6 | MIAA | ||
| 9/8/2018 | Hope (8-2) | 41 | at | Defiance | 0 | MIAA | ||
| 9/15/2018 | Defiance | 26 | at | Manchester (4-6,4-4) | 57 | |||
| 9/22/2018 | Anderson (2-8,2-6) | 18 | at | Defiance | 14 | |||
| 10/6/2018 | Franklin (8-2,7-1) | 55 | at | Defiance | 28 | |||
| 10/13/2018 | Defiance | 7 | at | Hanover (7-4,7-1) | 48 | |||
| 10/20/2018 | Mt St Joseph (8-2,7-1) | 20 | at | Defiance | 0 | |||
| 10/27/2018 | Rose-Hulman (5-5,5-3) | 35 | at | Defiance | 6 | |||
| 11/3/2018 | Defiance | 28 | at | Earlham (0-10,0-8) | 10 | |||
| 11/10/2018 | Defiance | 7 | at | Bluffton (3-7,3-5) | 34 |
| vs Defiance | vs Other Opponents | Defiance compared to OOs | |
| Record: | 9-1 | 43-48 | |
| Points Scored: | 37.70 | 29.25 | -8.45 |
| Points Allowed: | 12.20 | 30.44 | -18.24 |
| Margin: | 25.50 | -1.19 | -26.69 |
| Total Points: | 49.90 | 59.69 | -9.79 |