| 8/30/2018 | North Greenville (4-6) | 13 | at | Tusculum | 3 | GSC | ||
| 9/8/2018 | Tusculum | 61 | at | Shorter (0-11) | 14 | at GSC | ||
| 9/14/2018 | Limestone (0-10,0-7) | 10 | at | Tusculum | 37 | |||
| 9/22/2018 | UNC Pembroke (2-8) | at | Tusculum | CCD | D2Ind | |||
| 9/29/2018 | Tusculum | 10 | at | Lenoir-Rhyne (12-2,8-0) | 35 | |||
| 10/6/2018 | Tusculum | 31 | at | Mars Hill (4-6,3-4) | 28 | |||
| 10/13/2018 | Newberry (5-6,3-4) | 0 | at | Tusculum | 14 | |||
| 10/20/2018 | Tusculum | 37 | at | Catawba (4-7,2-5) | 55 | |||
| 10/27/2018 | Carson-Newman (7-4,4-3) | 28 | at | Tusculum | 41 | |||
| 11/3/2018 | Tusculum | 11 | at | VMI (1-10) | 20 | at SoCon | ||
| 11/10/2018 | Tusculum | 12 | at | Wingate (9-4,5-3) | 16 |
| vs Tusculum | vs Other Opponents | Tusculum compared to OOs | |
| Record: | 5-5 | 43-69 | |
| Points Scored: | 21.90 | 26.29 | 4.39 |
| Points Allowed: | 25.70 | 32.30 | -6.60 |
| Margin: | -3.80 | -6.01 | -2.21 |
| Total Points: | 47.60 | 58.59 | -10.99 |