| 8/30/2018 | Harding (9-3,9-2) | 41 | at | Henderson State | 17 | | | |
| 9/8/2018 | Henderson State | 38 | at | Arkansas Tech (3-8,3-8) | 31 | | | |
| 9/15/2018 | Henderson State | 24 | at | Northwestern Oklahoma State (4-7,4-7) | 30 | | | |
| 9/22/2018 | Southwestern Oklahoma State (3-8,3-8) | 35 | at | Henderson State | 31 | | | |
| 9/29/2018 | Henderson State | 24 | at | Southern Nazarene (3-8,3-8) | 10 | | | |
| 10/6/2018 | Oklahoma Baptist (5-6,5-6) | 21 | at | Henderson State | 56 | | | |
| 10/13/2018 | Henderson State | 31 | at | East Central (3-8,3-8) | 10 | | | |
| 10/20/2018 | Southeastern Oklahoma State (6-5,6-5) | 17 | at | Henderson State | 20 | | | |
| 10/27/2018 | Southern Arkansas (8-4,8-3) | 34 | vs | Henderson State | 14 | | El Dorado AR | |
| 11/3/2018 | Arkansas-Monticello (6-6,6-5) | 24 | at | Henderson State | 17 | | | |
| 11/10/2018 | Ouachita (12-1,11-0) | 38 | at | Henderson State | 10 | | | |