| 8/30/2018 | University of New England | 7 | at | Coast Guard | 33 | CCF | ||
| 8/31/2018 | Worcester Polytechnic | 54 | at | Anna Maria | 0 | @ ECFC | ||
| Becker | 3 | at | MIT | 23 | CCF | |||
| Western New England | 21 | at | Springfield | 42 | CCF | |||
| 9/1/2018 | McDaniel | 27 | at | Catholic | 12 | Cen | ||
| SUNY-Maritime | 36 | at | Maine Maritime | 8 | ECFC | |||
| Merchant Marine | 30 | at | Misericordia | 9 | @ MidAC | |||
| Morrisville | 34 | at | Norwich | 13 | E8 | |||
| 9/7/2018 | MIT | 16 | at | Curry | 6 | @ CCF | ||
| 9/8/2018 | Union NY | 28 | at | Coast Guard | 10 | LL | ||
| Springfield | 42 | at | Kean | 0 | @ NJAC | |||
| Worcester Polytechnic | 14 | at | Rensselaer | 25 | @ LL | |||
| Norwich | 7 | at | St Lawrence | 40 | @ LL | |||
| Catholic | 21 | at | Utica | 45 | @ E8 | |||
| 9/12/2018 | Catholic | 6 | at | Randolph-Macon | 41 | @ ODC | ||
| 9/14/2018 | Coast Guard | 27 | at | Nichols | 20 | @ CCF | ||
| Merchant Marine | 34 | at | SUNY-Maritime | 21 | @ ECFC | |||
| 9/15/2018 | Worcester Polytechnic | 45 | at | Becker | 0 | @ CCF | ||
| MIT | 31 | at | Endicott | 29 | @ CCF | |||
| Maine Maritime | 7 | at | Massachusetts Maritime | 22 | @ MSCAC | |||
| Castleton State | 0 | at | Norwich | 40 | ECFC | |||
| Union NY | 45 | at | Springfield | 10 | LL | |||
| 9/22/2018 | Norwich | 35 | at | Coast Guard | 38 | |||
| Maine Maritime | 14 | at | Merchant Marine | 35 | ||||
| Catholic | 24 | at | MIT | 34 | ||||
| Springfield | 17 | at | Worcester Polytechnic | 14 | ||||
| 9/29/2018 | Coast Guard | 20 | at | Catholic | 9 | |||
| Worcester Polytechnic | 30 | at | Maine Maritime | 7 | ||||
| Merchant Marine | 24 | at | MIT | 31 | ||||
| Springfield | 33 | at | Norwich | 16 | ||||
| 10/6/2018 | MIT | 35 | at | Maine Maritime | 0 | |||
| Norwich | 24 | at | Merchant Marine | 33 | ||||
| Coast Guard | 12 | at | Springfield | 26 | ||||
| Catholic | 0 | at | Worcester Polytechnic | 24 | ||||
| 10/13/2018 | Maine Maritime | 0 | at | Coast Guard | 15 | |||
| Merchant Marine | 17 | at | Springfield | 14 | ||||
| 10/20/2018 | Springfield | 23 | at | Catholic | 11 | |||
| Norwich | 15 | at | Maine Maritime | 7 | ||||
| Worcester Polytechnic | 24 | at | Merchant Marine | 25 | ||||
| Coast Guard | 0 | at | MIT | 13 | ||||
| 10/27/2018 | Catholic | 0 | at | Norwich | 31 | |||
| MIT | 6 | at | Worcester Polytechnic | 13 | ||||
| 11/3/2018 | Merchant Marine | 44 | at | Catholic | 10 | |||
| Worcester Polytechnic | 10 | at | Coast Guard | 24 | ||||
| MIT | 20 | at | Norwich | 0 | ||||
| Maine Maritime | 7 | at | Springfield | 44 | ||||
| 11/10/2018 | Maine Maritime | 14 | at | Catholic | 20 | |||
| Coast Guard | 26 | at | Merchant Marine | 12 | ||||
| Springfield | 7 | at | MIT | 22 | ||||
| Norwich | 17 | at | Worcester Polytechnic | 20 | ||||
| 11/17/2018 | Merchant Marine | 38 | at | Endicott | 22 | @ CCF | ||
| MIT | 0 | at | Johns Hopkins | 49 | D3 Playooff Round 1 | @ Cen | ||
| SUNY-Maritime | 14 | at | Springfield | 17 | ECFC |