| 8/31/2017 | Ohio Dominican | 34 | at | California PA | 36 | @ PSAC | ||
| Kentucky Wesleyan | 7 | at | Murray State | 67 | @ OVC (1AA) | |||
| Findlay | 28 | at | Tiffin | 13 | @ GLIAC | |||
| 9/2/2017 | Saginaw Valley State | 42 | at | Alderson-Broaddus | 24 | GLIAC | ||
| Lake Erie | 3 | at | Edinboro | 30 | @ PSAC | |||
| Hillsdale | 19 | at | Mercyhurst | 11 | @ PSAC | |||
| Malone | 21 | at | Taylor | 28 | @ MSFA (NAIA) | |||
| Wayne State MI | 28 | at | Walsh | 9 | GLIAC | |||
| 9/9/2017 | Ohio Dominican | 21 | at | Ashland | 47 | @ GLIAC | ||
| Ferris State | 48 | at | Findlay | 27 | GLIAC | |||
| Michigan Tech | 27 | at | Hillsdale | 31 | GLIAC | |||
| Livingstone | 13 | at | Kentucky Wesleyan | 33 | CIAA | |||
| Tiffin | 58 | at | Lake Erie | 7 | GLIAC | |||
| Alderson-Broaddus | 21 | at | Quincy | 50 | @ GLV | |||
| Walsh | 0 | at | Saginaw Valley State | 28 | @ GLIAC | |||
| 9/16/2017 | Lincoln PA | 10 | at | Alderson-Broaddus | 48 | CIAA | ||
| McKendree | 24 | at | Hillsdale | 21 | GLV | |||
| Walsh | 31 | at | Jacksonville | 56 | @ Pio (1AA) | |||
| Kentucky Wesleyan | 23 | at | Kentucky State | 30 | @ SIAC | |||
| Urbana | 37 | at | Lake Erie | 10 | MtnE | |||
| Ohio Dominican | 24 | at | Pennsylvania | 42 | @ Ivy (1AA) | |||
| Malone | 27 | at | Shaw | 34 | @ CIAA | |||
| Findlay | 55 | at | William Jewell | 17 | @ GLV | |||
| 9/23/2017 | Glenville State | 47 | at | Alderson-Broaddus | 42 | MtnE | ||
| Walsh | 6 | at | Central Conn | 57 | @ NE (1AA) | |||
| Tuskegee | 0 | at | Findlay | 61 | SIAC | |||
| Hillsdale | 38 | at | Indianapolis | 45 | @ GLV | |||
| Missouri S&T | 48 | at | Malone | 21 | GLV | |||
| Lake Erie | 0 | at | Ohio Dominican | 51 | ||||
| 9/30/2017 | Kentucky Wesleyan | 0 | at | Hillsdale | 56 | |||
| Alderson-Broaddus | 15 | at | Lake Erie | 16 | ||||
| Ohio Dominican | 20 | at | Malone | 3 | ||||
| Findlay | 47 | at | Walsh | 3 | ||||
| 10/7/2017 | Malone | 24 | at | Alderson-Broaddus | 31 | |||
| Lake Erie | 3 | at | Findlay | 63 | ||||
| Walsh | 56 | at | Kentucky Wesleyan | 29 | ||||
| Hillsdale | 27 | at | Ohio Dominican | 41 | ||||
| 10/14/2017 | Findlay | 31 | at | Hillsdale | 13 | |||
| Kentucky Wesleyan | 34 | at | Malone | 30 | ||||
| Alderson-Broaddus | 36 | at | Walsh | 38 | ||||
| 10/20/2017 | Kentucky Wesleyan | 14 | at | Findlay | 68 | |||
| 10/21/2017 | Ohio Dominican | 53 | at | Alderson-Broaddus | 13 | |||
| Walsh | 0 | at | Hillsdale | 38 | ||||
| Malone | 24 | at | Lake Erie | 13 | ||||
| 10/26/2017 | Findlay | 49 | at | Malone | 0 | |||
| 10/28/2017 | Hillsdale | 37 | at | Alderson-Broaddus | 31 | |||
| Lake Erie | 45 | at | Kentucky Wesleyan | 27 | ||||
| Ohio Dominican | 39 | at | Walsh | 21 | ||||
| 11/4/2017 | Alderson-Broaddus | 28 | at | Findlay | 70 | |||
| Malone | 7 | at | Hillsdale | 45 | ||||
| Walsh | 31 | at | Lake Erie | 7 | ||||
| Kentucky Wesleyan | 7 | at | Ohio Dominican | 63 | ||||
| 11/11/2017 | Alderson-Broaddus | 40 | at | Kentucky Wesleyan | 28 | |||
| Hillsdale | 54 | at | Lake Erie | 0 | ||||
| Walsh | 38 | at | Malone | 24 | ||||
| Findlay | 24 | at | Ohio Dominican | 49 | ||||
| 11/18/2017 | Findlay | 29 | at | Shepherd | 17 | @ MtnE | ||
| 11/25/2017 | Findlay | 26 | at | Assumption | 45 | D2 Playoff Round 2 | @ NE10 |