| 8/31/2017 | Moravian | 27 | at | King's | 30 | @ MidAC | ||
| 9/1/2017 | Gettysburg | 24 | at | Bridgewater VA | 27 | @ ODC | ||
| Johns Hopkins | 32 | at | Washington and Lee | 29 | OT | @ ODC | ||
| 9/2/2017 | Grove City | 31 | at | Juniata | 42 | TPAC | ||
| Franklin & Marshall | 48 | at | Lebanon Valley | 7 | @ MidAC | |||
| Catholic | 10 | at | McDaniel | 30 | NEWMAC | |||
| Wilkes | 19 | at | Muhlenberg | 62 | MidAC | |||
| Dickinson | 6 | at | Randolph-Macon | 41 | @ ODC | |||
| Lycoming | 6 | at | Susquehanna | 7 | MidAC | |||
| Bethany WV | 13 | at | Ursinus | 35 | TPAC | |||
| 9/9/2017 | Muhlenberg | 25 | at | Dickinson | 6 | |||
| Juniata | 7 | at | Franklin & Marshall | 52 | ||||
| Ursinus | 35 | at | Gettysburg | 28 | ||||
| Susquehanna | 34 | at | Johns Hopkins | 38 | ||||
| McDaniel | 35 | at | Moravian | 14 | ||||
| 9/16/2017 | McDaniel | 41 | at | Franklin & Marshall | 43 | |||
| Dickinson | 24 | at | Gettysburg | 21 | ||||
| Moravian | 7 | at | Johns Hopkins | 37 | ||||
| Susquehanna | 14 | at | Muhlenberg | 11 | ||||
| Juniata | 28 | at | Ursinus | 35 | ||||
| 9/23/2017 | Johns Hopkins | 41 | at | Dickinson | 10 | |||
| Muhlenberg | 56 | at | Juniata | 40 | ||||
| Gettysburg | 20 | at | McDaniel | 27 | OT | |||
| Ursinus | 35 | at | Moravian | 17 | ||||
| Franklin & Marshall | 27 | at | Susquehanna | 24 | ||||
| 9/30/2017 | Muhlenberg | 14 | at | Franklin & Marshall | 17 | |||
| Moravian | 14 | at | Gettysburg | 28 | ||||
| Juniata | 42 | at | McDaniel | 41 | OT | |||
| Dickinson | 7 | at | Susquehanna | 38 | ||||
| Johns Hopkins | 17 | at | Ursinus | 21 | ||||
| 10/7/2017 | McDaniel | 10 | at | Dickinson | 13 | |||
| Franklin & Marshall | 7 | at | Johns Hopkins | 45 | ||||
| Gettysburg | 42 | at | Juniata | 35 | ||||
| Susquehanna | 28 | at | Moravian | 21 | ||||
| Ursinus | 14 | at | Muhlenberg | 21 | ||||
| 10/20/2017 | Gettysburg | 0 | at | Johns Hopkins | 52 | |||
| 10/21/2017 | Dickinson | 0 | at | Franklin & Marshall | 56 | |||
| Moravian | 20 | at | Juniata | 17 | ||||
| Muhlenberg | 40 | at | McDaniel | 13 | ||||
| Ursinus | 14 | at | Susquehanna | 21 | ||||
| 10/28/2017 | Juniata | 38 | at | Dickinson | 14 | |||
| Susquehanna | 21 | at | Gettysburg | 29 | ||||
| Franklin & Marshall | 36 | at | Moravian | 14 | ||||
| Johns Hopkins | 31 | at | Muhlenberg | 24 | ||||
| McDaniel | 21 | at | Ursinus | 28 | ||||
| 11/4/2017 | Muhlenberg | 39 | at | Gettysburg | 14 | |||
| Juniata | 14 | at | Johns Hopkins | 57 | ||||
| Dickinson | 18 | at | Moravian | 35 | ||||
| McDaniel | 10 | at | Susquehanna | 33 | ||||
| Franklin & Marshall | 42 | at | Ursinus | 28 | ||||
| 11/11/2017 | Ursinus | 17 | at | Dickinson | 40 | |||
| Gettysburg | 21 | at | Franklin & Marshall | 51 | ||||
| Susquehanna | 28 | at | Juniata | 21 | ||||
| Johns Hopkins | 56 | at | McDaniel | 21 | ||||
| Moravian | 14 | at | Muhlenberg | 29 | ||||
| 11/18/2017 | Susquehanna | 28 | at | Albright | 9 | @ MidAC | ||
| Muhlenberg | 32 | vs | Carnegie Mellon | 6 | Asa Bushnell Bowl (Newark DE) | vs TPAC | ||
| Widener | 7 | at | Franklin & Marshall | 21 | MidAC | |||
| Johns Hopkins | 28 | at | Washington & Jefferson | 31 | @ TPAC |