| 8/25/2016 | Jamestown | 10 | at | Valley City State | 15 | |||
| 8/26/2016 | Dakota State | 34 | at | Dakota Wesleyan | 30 | @ GPAC | ||
| 8/27/2016 | Waldorf | 19 | at | Briar Cliff | 23 | @ GPAC | ||
| Montana-Western | 29 | vs | Dickinson State | 13 | Miles City MT | vs Front | ||
| 9/3/2016 | Valley City State | 13 | at | Dickinson State | 38 | |||
| Dakota State | 42 | at | Dordt | 45 | @ GPAC | |||
| Concordia-Moorhead | 13 | at | Jamestown | 30 | MIA (D3) | |||
| Buena Vista | 33 | at | Mayville State | 42 | IIAC (D3) | |||
| Lawrence | 10 | at | Presentation | 17 | MidW (D3) | |||
| Trinity Bible | 0 | at | Waldorf | 42 | None (Unk?) | |||
| 9/10/2016 | Saint Ambrose | 48 | at | Dakota State | 62 | MSFA | ||
| Northwestern IA | 13 | at | Dickinson State | 42 | GPAC | |||
| Dakota Wesleyan | 55 | at | Jamestown | 17 | GPAC | |||
| Waldorf | 18 | at | Kansas Wesleyan | 28 | @ KCAC | |||
| Briar Cliff | 0 | at | Presentation | 29 | GPAC | |||
| Mayville State | 7 | at | Quincy | 64 | @ GLV (D2) | |||
| Hastings | 35 | at | Valley City State | 32 | GPAC | |||
| 9/17/2016 | Waldorf | 14 | at | Dakota State | 36 | |||
| Jamestown | 34 | at | Hastings | 44 | @ GPAC | |||
| Wisconsin-Stout | 23 | at | Mayville State | 13 | WIAC (D3) | |||
| 9/24/2016 | Jamestown | 17 | at | Dakota State | 36 | |||
| Presentation | 36 | at | Dickinson State | 55 | ||||
| Trinity Bible | 6 | at | Mayville State | 35 | None (Unk?) | |||
| Waldorf | 7 | at | Valley City State | 36 | ||||
| 10/1/2016 | Presentation | 58 | at | Trinity Bible | 2 | @ None (Unk?) | ||
| Dickinson State | 34 | at | Valley City State | 7 | ||||
| Dakota State | 37 | at | Waldorf | 13 | ||||
| 10/8/2016 | Presentation | 34 | at | Jamestown | 25 | |||
| Valley City State | 21 | at | Mayville State | 15 | ||||
| Dickinson State | 49 | at | Waldorf | 20 | ||||
| 10/15/2016 | Valley City State | 41 | at | Dakota State | 22 | |||
| Jamestown | 13 | at | Dickinson State | 41 | ||||
| Waldorf | 28 | at | Mayville State | 35 | ||||
| Finlandia | 0 | at | Presentation | 74 | D3Ind (D3) | |||
| 10/22/2016 | Dakota State | 12 | at | Dickinson State | 31 | |||
| Mayville State | 13 | at | Jamestown | 20 | ||||
| Presentation | 7 | at | Valley City State | 28 | ||||
| 10/29/2016 | Dickinson State | 20 | at | Black Hills State | 33 | @ RMAC (D2) | ||
| Mayville State | 27 | at | Dakota State | 25 | ||||
| Valley City State | 21 | at | Jamestown | 27 | ||||
| Waldorf | 21 | at | Presentation | 31 | ||||
| 11/5/2016 | Dickinson State | 41 | at | Mayville State | 28 | |||
| Dakota State | 24 | at | Presentation | 10 | ||||
| Jamestown | 20 | at | Waldorf | 14 | ||||
| 11/10/2016 | Valley City State | 17 | at | Southeastern FL | 13 | @ Sun | ||
| 11/12/2016 | Dickinson State | 41 | at | Jamestown | 14 | |||
| Mayville State | 22 | at | Presentation | 49 | ||||
| 11/19/2016 | Dickinson State | 21 | at | Montana Tech | 28 | @ Front |