| 8/25/2016 | Wayland Baptist (7-3,5-2) | 37 | at | Lyon | 14 | |||
| 9/3/2016 | Lyon | 17 | at | Lindsey Wilson (11-2) | 63 | at MSC | ||
| 9/10/2016 | Hendrix (7-3) | 49 | at | Lyon | 14 | SAA (D3) | ||
| 9/24/2016 | Lyon | 21 | at | Bacone (2-8,2-4) | 34 | |||
| 10/1/2016 | Southwestern Assemblies of God (4-6,2-4) | 42 | at | Lyon | 48 | OT | ||
| 10/8/2016 | Texas College (0-9,0-6) | 21 | at | Lyon | 35 | |||
| 10/22/2016 | Arizona Christian (7-3,6-0) | 34 | at | Lyon | 17 | |||
| 10/29/2016 | Lyon | 14 | at | Wayland Baptist (7-3,5-2) | 52 | |||
| 11/5/2016 | Lyon | 12 | at | Langston (7-2,5-1) | 40 | |||
| 11/12/2016 | Lyon | 38 | at | Missouri Baptist (3-8) | 70 | at MSFA |
| vs Lyon | vs Other Opponents | Lyon compared to OOs | |
| Record: | 8-2 | 45-45 | |
| Points Scored: | 44.20 | 31.87 | -12.33 |
| Points Allowed: | 23.00 | 35.29 | -12.29 |
| Margin: | 21.20 | -3.42 | -24.62 |
| Total Points: | 67.20 | 67.16 | 0.04 |