| 9/2/2016 | Nichols | 21 | at | Westfield State (2-8) | 34 | at MSCAC | ||
| 9/9/2016 | Anna Maria (1-9) | 7 | at | Nichols | 22 | ECFC | ||
| 9/17/2016 | Nichols | 16 | at | Becker (3-7) | 13 | at ECFC | ||
| 9/24/2016 | Nichols | 0 | at | Endicott (5-5,5-2) | 37 | |||
| 10/1/2016 | Western New England (11-2,7-0) | 56 | at | Nichols | 27 | |||
| 10/15/2016 | Nichols | 14 | at | Salve Regina (8-2,6-1) | 52 | |||
| 10/22/2016 | Coast Guard (3-7,2-5) | 14 | at | Nichols | 24 | |||
| 10/29/2016 | Curry (3-6,1-6) | 35 | at | Nichols | 43 | |||
| 11/5/2016 | Nichols | 54 | at | Maine Maritime (1-8,0-7) | 28 | |||
| 11/12/2016 | MIT (3-7,3-4) | 35 | at | Nichols | 36 | 2OT |
| vs Nichols | vs Other Opponents | Nichols compared to OOs | |
| Record: | 4-6 | 36-55 | |
| Points Scored: | 31.10 | 25.14 | -5.96 |
| Points Allowed: | 25.70 | 28.42 | -2.72 |
| Margin: | 5.40 | -3.28 | -8.68 |
| Total Points: | 56.80 | 53.56 | 3.24 |