| 9/3/2016 | Cornell IA (5-5) | 51 | at | Iowa Wesleyan | 21 | MidW | ||
| 9/10/2016 | Westminster MO (4-6,4-5) | 24 | at | Iowa Wesleyan | 7 | |||
| 9/17/2016 | Iowa Wesleyan | 40 | at | Greenville (2-8,2-7) | 37 | |||
| 9/24/2016 | Iowa Wesleyan | 27 | at | Minnesota-Morris (6-4,5-4) | 28 | |||
| 10/1/2016 | Northwestern MN (9-2,8-1) | 25 | at | Iowa Wesleyan | 18 | |||
| 10/8/2016 | St Scholastica (7-3,7-2) | 45 | at | Iowa Wesleyan | 7 | |||
| 10/15/2016 | Iowa Wesleyan | 15 | at | Eureka (8-2,7-2) | 29 | |||
| 10/22/2016 | MacMurray (8-2,7-2) | 37 | at | Iowa Wesleyan | 21 | |||
| 10/29/2016 | Martin Luther (0-10,0-9) | 0 | at | Iowa Wesleyan | 38 | |||
| 11/5/2016 | Iowa Wesleyan | 19 | at | Crown (2-8,2-7) | 13 |
| vs Iowa Wesleyan | vs Other Opponents | Iowa Wesleyan compared to OOs | |
| Record: | 7-3 | 44-47 | |
| Points Scored: | 28.90 | 24.03 | -4.87 |
| Points Allowed: | 21.30 | 26.51 | -5.21 |
| Margin: | 7.60 | -2.48 | -10.08 |
| Total Points: | 50.20 | 50.54 | -0.34 |