| 9/1/2016 | Southern Arkansas (9-3,9-2) | 21 | at | Southwestern Oklahoma State | 17 | | | |
| 9/10/2016 | Southwestern Oklahoma State | 28 | at | Arkansas-Monticello (4-7,4-7) | 35 | | | |
| 9/17/2016 | Southwestern Oklahoma State | 28 | at | Ouachita (7-4,7-4) | 48 | | | |
| 9/24/2016 | Henderson State (8-3,8-3) | 45 | at | Southwestern Oklahoma State | 17 | | | |
| 10/1/2016 | Southeastern Oklahoma State (7-4,7-4) | 33 | at | Southwestern Oklahoma State | 37 | | | |
| 10/8/2016 | Southwestern Oklahoma State | 41 | at | East Central (1-10,1-10) | 7 | | | |
| 10/15/2016 | Southwestern Oklahoma State | 35 | at | Southern Nazarene (2-9,2-9) | 14 | | | |
| 10/20/2016 | Oklahoma Baptist (2-9,2-9) | 35 | at | Southwestern Oklahoma State | 37 | | | |
| 10/29/2016 | Southwestern Oklahoma State | 27 | at | Harding (13-1,11-0) | 42 | | | |
| 11/5/2016 | Arkansas Tech (6-5,6-5) | 24 | at | Southwestern Oklahoma State | 20 | | | |
| 11/12/2016 | Northwestern Oklahoma State (4-7,4-7) | 16 | at | Southwestern Oklahoma State | 47 | | | |