| 9/1/2016 | Southeastern Oklahoma State (7-4,7-4) | 11 | at | Henderson State | 13 | | | |
| 9/10/2016 | Henderson State | 34 | at | East Central (1-10,1-10) | 7 | | | |
| 9/17/2016 | Northwestern Oklahoma State (4-7,4-7) | 23 | at | Henderson State | 62 | | | |
| 9/24/2016 | Henderson State | 45 | at | Southwestern Oklahoma State (5-6,5-6) | 17 | | | |
| 10/1/2016 | Henderson State | 27 | at | Arkansas Tech (6-5,6-5) | 20 | | | |
| 10/8/2016 | Harding (13-1,11-0) | 35 | at | Henderson State | 3 | | | |
| 10/15/2016 | Arkansas-Monticello (4-7,4-7) | 17 | at | Henderson State | 45 | | | |
| 10/22/2016 | Henderson State | 24 | vs | Southern Arkansas (9-3,9-2) | 50 | | El Dorado AR | |
| 10/29/2016 | Oklahoma Baptist (2-9,2-9) | 21 | at | Henderson State | 67 | | | |
| 11/5/2016 | Henderson State | 40 | at | Southern Nazarene (2-9,2-9) | 7 | | | |
| 11/12/2016 | Ouachita (7-4,7-4) | 30 | at | Henderson State | 27 | | | |