| 9/3/2016 | Point (3-6) | 16 | at | Mississippi College | 28 | Sun (NAIA) | ||
| 9/10/2016 | Mississippi College | 0 | at | Florida Tech (8-3,5-2) | 41 | |||
| 9/17/2016 | West Alabama (7-4,6-2) | 38 | at | Mississippi College | 13 | |||
| 9/24/2016 | Cumberland TN (5-6) | 26 | at | Mississippi College | 27 | MSC (NAIA) | ||
| 9/29/2016 | Mississippi College | 31 | at | Delta State (4-6,3-5) | 61 | |||
| 10/8/2016 | West Florida (5-6,3-5) | 42 | at | Mississippi College | 28 | |||
| 10/15/2016 | Valdosta State (8-3,6-2) | 42 | at | Mississippi College | 41 | |||
| 10/22/2016 | Mississippi College | 23 | at | West Georgia (7-4,4-4) | 31 | |||
| 11/5/2016 | Mississippi College | 32 | at | Shorter (0-11,0-8) | 0 | |||
| 11/12/2016 | North Alabama (11-2,7-0) | 42 | at | Mississippi College | 7 |
| vs Mississippi College | vs Other Opponents | Mississippi College compared to OOs | |
| Record: | 7-3 | 51-48 | |
| Points Scored: | 33.90 | 28.78 | -5.12 |
| Points Allowed: | 23.00 | 27.98 | -4.98 |
| Margin: | 10.90 | 0.80 | -10.10 |
| Total Points: | 56.90 | 56.76 | 0.14 |