| 9/4/2016 | Texas Southern (4-7,4-5) | 25 | at | Prairie View | 29 | |||
| 9/10/2016 | Prairie View | 0 | at | Texas A&M (8-5) | 67 | at SEC | ||
| 9/17/2016 | Prairie View | 41 | at | Alabama A&M (4-7,4-5) | 20 | |||
| 9/24/2016 | Prairie View | 56 | at | Mississippi Valley State (1-10,1-8) | 21 | |||
| 10/1/2016 | Prairie View | 16 | vs | Grambling (11-1,10-0) | 36 | Dallas TX | ||
| 10/8/2016 | Alabama State (4-7,3-6) | 17 | at | Prairie View | 24 | |||
| 10/22/2016 | Prairie View | 44 | at | Rice (3-9) | 65 | at CUSA | ||
| 10/29/2016 | Prairie View | 28 | at | Jackson State (3-8,3-6) | 14 | |||
| 11/5/2016 | Alcorn State (5-6,5-5) | 27 | at | Prairie View | 31 | |||
| 11/12/2016 | Southern (8-3,8-1) | 44 | at | Prairie View | 34 | |||
| 11/19/2016 | Prairie View | 57 | at | Ark Pine Bluff (1-10,1-8) | 7 |
| vs Prairie View | vs Other Opponents | Prairie View compared to OOs | |
| Record: | 4-7 | 48-66 | |
| Points Scored: | 31.18 | 26.07 | -5.11 |
| Points Allowed: | 32.73 | 31.11 | 1.62 |
| Margin: | -1.55 | -5.04 | -3.49 |
| Total Points: | 63.91 | 57.18 | 6.73 |