| 9/5/2015 | Guilford | 77 | at | Greensboro (3-7) | 13 | at USASC | ||
| 9/12/2015 | Guilford | 55 | at | Methodist (4-6) | 7 | at USASC | ||
| 9/19/2015 | Averett (2-7) | 21 | at | Guilford | 58 | USASC | ||
| 10/3/2015 | Guilford | 17 | at | Washington and Lee (10-1,7-0) | 20 | |||
| 10/10/2015 | Shenandoah (4-6,1-6) | 38 | at | Guilford | 55 | |||
| 10/17/2015 | Guilford | 23 | at | Bridgewater VA (4-6,2-5) | 20 | |||
| 10/24/2015 | Randolph-Macon (4-6,3-4) | 21 | at | Guilford | 41 | |||
| 10/31/2015 | Guilford | 52 | at | Catholic (3-7,1-6) | 49 | |||
| 11/7/2015 | Hampden-Sydney (6-4,4-3) | 20 | at | Guilford | 33 | |||
| 11/14/2015 | Emory & Henry (6-4,4-3) | 30 | at | Guilford | 41 |
| vs Guilford | vs Other Opponents | Guilford compared to OOs | |
| Record: | 1-9 | 45-45 | |
| Points Scored: | 23.90 | 29.40 | 5.50 |
| Points Allowed: | 45.20 | 29.62 | 15.58 |
| Margin: | -21.30 | -0.22 | 21.08 |
| Total Points: | 69.10 | 59.02 | 10.08 |