| 9/5/2015 | Albany NY (3-8) | 14 | at | Buffalo | 51 | CAAF (1AA) | ||
| 9/12/2015 | Buffalo | 14 | at | Penn State (7-6) | 27 | at B10 | ||
| 9/19/2015 | Buffalo | 33 | at | Florida Atlantic (3-9) | 15 | at CUSA | ||
| 9/26/2015 | Nevada (7-6) | 24 | at | Buffalo | 21 | MW | ||
| 10/3/2015 | Bowling Green (10-4,8-1) | 28 | at | Buffalo | 22 | |||
| 10/17/2015 | Buffalo | 14 | at | Central Michigan (7-6,6-2) | 51 | |||
| 10/24/2015 | Ohio (8-5,5-3) | 17 | at | Buffalo | 41 | |||
| 10/29/2015 | Buffalo | 29 | at | Miami-Ohio (3-9,2-6) | 24 | |||
| 11/5/2015 | Buffalo | 18 | at | Kent State (3-9,2-6) | 17 | |||
| 11/11/2015 | Northern Illinois (8-6,6-3) | 41 | at | Buffalo | 30 | |||
| 11/21/2015 | Buffalo | 21 | at | Akron (8-5,5-3) | 42 | |||
| 11/27/2015 | Massachusetts (3-9,2-6) | 31 | at | Buffalo | 26 |
| vs Buffalo | vs Other Opponents | Buffalo compared to OOs | |
| Record: | 7-5 | 63-77 | |
| Points Scored: | 27.58 | 24.40 | -3.18 |
| Points Allowed: | 26.67 | 26.66 | 0.01 |
| Margin: | 0.91 | -2.26 | -3.17 |
| Total Points: | 54.25 | 51.06 | 3.19 |