| 9/3/2015 | Manchester | 14 | at | Trine | 38 | @ MIAA | ||
| 9/5/2015 | Defiance | 13 | at | Adrian | 31 | @ MIAA | ||
| Mt St Joseph | 39 | at | Augustana IL | 42 | @ CCIW | |||
| Illinois Wesleyan | 34 | at | Franklin | 24 | CCIW | |||
| Centre | 63 | at | Hanover | 7 | SAA | |||
| Earlham | 13 | at | Olivet | 74 | @ MIAA | |||
| Kalamazoo | 14 | at | Rose-Hulman | 29 | MIAA | |||
| Anderson | 10 | at | Taylor | 51 | @ MSFA (NAIA) | |||
| Bluffton | 10 | at | Wilmington | 14 | @ OAC | |||
| 9/12/2015 | Concordia MI | 42 | at | Anderson | 26 | MSFA (NAIA) | ||
| Baldwin-Wallace | 26 | at | Bluffton | 38 | OAC | |||
| Franklin | 14 | at | Butler | 41 | @ Pio (1AA) | |||
| Defiance | 8 | at | Centre | 25 | @ SAA | |||
| DePauw | 53 | at | Earlham | 0 | NCA | |||
| Rose-Hulman | 51 | at | Illinois College | 33 | @ MidW | |||
| Hanover | 7 | at | Thomas More | 84 | @ TPAC | |||
| 9/19/2015 | Manchester | 67 | at | Earlham | 23 | |||
| Anderson | 0 | at | Franklin | 56 | ||||
| Defiance | 20 | at | Mt St Joseph | 38 | ||||
| Hanover | 7 | at | Rose-Hulman | 35 | ||||
| 9/26/2015 | Earlham | 20 | at | Anderson | 51 | |||
| Franklin | 49 | at | Bluffton | 31 | ||||
| Hanover | 14 | at | Defiance | 19 | ||||
| Mt St Joseph | 31 | at | Manchester | 54 | ||||
| 10/3/2015 | Rose-Hulman | 81 | at | Anderson | 13 | |||
| Manchester | 0 | at | Franklin | 42 | ||||
| Bluffton | 56 | at | Hanover | 10 | ||||
| Earlham | 27 | at | Mt St Joseph | 58 | ||||
| 10/10/2015 | Rose-Hulman | 28 | at | Bluffton | 27 | |||
| Manchester | 42 | at | Defiance | 21 | ||||
| Franklin | 80 | at | Earlham | 19 | ||||
| Hanover | 28 | at | Mt St Joseph | 38 | ||||
| 10/17/2015 | Earlham | 20 | at | Bluffton | 51 | |||
| Mt St Joseph | 13 | at | Franklin | 52 | ||||
| Anderson | 21 | at | Hanover | 28 | ||||
| Defiance | 7 | at | Rose-Hulman | 42 | ||||
| 10/24/2015 | Mt St Joseph | 54 | at | Anderson | 22 | |||
| Earlham | 7 | at | Defiance | 51 | ||||
| Bluffton | 28 | at | Manchester | 20 | ||||
| Franklin | 42 | at | Rose-Hulman | 35 | ||||
| 10/31/2015 | Defiance | 13 | at | Anderson | 17 | |||
| Hanover | 35 | at | Earlham | 34 | OT | |||
| Rose-Hulman | 35 | at | Manchester | 28 | ||||
| Bluffton | 28 | at | Mt St Joseph | 31 | ||||
| 11/7/2015 | Anderson | 0 | at | Bluffton | 44 | |||
| Defiance | 7 | at | Franklin | 35 | ||||
| Manchester | 24 | at | Hanover | 21 | ||||
| Mt St Joseph | 27 | at | Rose-Hulman | 26 | OT | |||
| 11/14/2015 | Bluffton | 35 | at | Defiance | 14 | |||
| Rose-Hulman | 64 | at | Earlham | 13 | ||||
| Franklin | 53 | at | Hanover | 13 | ||||
| Anderson | 17 | at | Manchester | 35 | ||||
| Finlandia | 7 | at | Mt St Joseph | 59 | D3Ind | |||
| 11/21/2015 | Ohio Northern | 27 | at | Franklin | 22 | NCAA D3 Championship - First Round | OAC |