| 9/3/2015 | St Joseph's | 30 | at | Edinboro | 10 | @ PSAC | ||
| Southwest Baptist | 28 | at | Grand Valley State | 36 | @ GLIAC | |||
| Saginaw Valley State | 17 | at | Indianapolis | 27 | GLIAC | |||
| Chadron State | 40 | at | Missouri S&T | 27 | RMAC | |||
| 9/5/2015 | William Jewell | 30 | at | Drake | 44 | @ Pio (1AA) | ||
| Lincoln MO | 35 | at | Langston | 32 | @ CSFL (NAIA) | |||
| Truman State | 3 | at | Midwestern State | 31 | @ LSC | |||
| 9/12/2015 | St Joseph's | 0 | at | Alderson-Broaddus | 19 | @ D2Ind | ||
| St Francis IL | 13 | at | Lincoln MO | 10 | MSFA (NAIA) | |||
| Indianapolis | 22 | at | Marian IN | 28 | @ MSFA (NAIA) | |||
| Quincy | 14 | at | Northern Michigan | 31 | @ GLIAC | |||
| Friends | 0 | at | Southwest Baptist | 52 | KCAC (NAIA) | |||
| Missouri S&T | 20 | at | Texas A&M-Kingsville | 38 | @ LSC | |||
| Truman State | 20 | at | Wayne State MI | 21 | @ GLIAC | |||
| McKendree | 50 | at | West Liberty | 27 | @ MtnE | |||
| Colorado Mines | 42 | at | William Jewell | 7 | RMAC | |||
| 9/19/2015 | Southwest Baptist | 24 | at | Indianapolis | 26 | |||
| Northwood | 24 | at | McKendree | 27 | GLIAC | |||
| Lincoln MO | 37 | at | Quincy | 42 | ||||
| William Jewell | 9 | at | St Joseph's | 34 | ||||
| Missouri S&T | 10 | at | Truman State | 7 | ||||
| 9/26/2015 | Indianapolis | 38 | at | Hillsdale | 7 | @ GLIAC | ||
| Truman State | 31 | at | Lincoln MO | 14 | ||||
| St Joseph's | 27 | at | Missouri S&T | 39 | ||||
| Quincy | 33 | at | Southwest Baptist | 56 | ||||
| McKendree | 41 | at | William Jewell | 23 | ||||
| 10/3/2015 | Truman State | 13 | at | Indianapolis | 26 | |||
| McMurry | 34 | at | Lincoln MO | 14 | ASWC (D3) | |||
| Southwest Baptist | 13 | at | McKendree | 38 | ||||
| St Joseph's | 16 | at | Quincy | 18 | ||||
| Missouri S&T | 16 | at | William Jewell | 40 | ||||
| 10/10/2015 | Indianapolis | 34 | at | McKendree | 24 | |||
| William Jewell | 24 | at | Quincy | 21 | ||||
| Lincoln MO | 14 | at | St Joseph's | 42 | ||||
| Southwest Baptist | 14 | at | Truman State | 23 | ||||
| 10/17/2015 | Quincy | 20 | at | Indianapolis | 26 | |||
| Missouri S&T | 40 | at | Lincoln MO | 23 | ||||
| Truman State | 24 | at | St Francis IL | 20 | @ MSFA (NAIA) | |||
| McKendree | 29 | at | St Joseph's | 10 | ||||
| William Jewell | 35 | at | Southwest Baptist | 34 | ||||
| 10/24/2015 | Indianapolis | 41 | at | Lincoln MO | 18 | |||
| McKendree | 27 | at | Missouri S&T | 34 | ||||
| Ohio Dominican | 73 | at | Quincy | 28 | GLIAC | |||
| St Joseph's | 24 | at | Southwest Baptist | 23 | ||||
| Truman State | 40 | at | William Jewell | 28 | ||||
| 10/31/2015 | Lincoln MO | 0 | at | McKendree | 65 | |||
| Southwest Baptist | 46 | at | Missouri S&T | 42 | ||||
| Truman State | 19 | at | Quincy | 23 | ||||
| Indianapolis | 63 | at | William Jewell | 35 | ||||
| 11/7/2015 | Missouri S&T | 14 | at | Indianapolis | 38 | |||
| William Jewell | 34 | at | Lincoln MO | 31 | ||||
| Quincy | 30 | at | McKendree | 56 | ||||
| St Joseph's | 3 | at | Truman State | 10 | ||||
| 11/14/2015 | Quincy | 35 | at | Missouri S&T | 42 | |||
| William Jewell | 14 | at | South Dakota Tech | 35 | @ GNWAC | |||
| Indianapolis | 47 | at | St Joseph's | 24 | ||||
| Lincoln MO | 19 | at | Southwest Baptist | 62 | ||||
| McKendree | 31 | at | Truman State | 3 | ||||
| 11/21/2015 | Indianapolis | 14 | at | Colorado State-Pueblo | 27 | NCAA D2 Championship - First Round | @ RMAC |