| 9/5/2015 | Truman State (5-6) | 3 | at | Midwestern State | 31 | GLV | ||
| 9/12/2015 | Midwestern State | 16 | at | Colorado Mesa (9-2) | 13 | OT | at RMAC | |
| 9/19/2015 | Midwestern State | 28 | vs | Eastern New Mexico (6-6,3-5) | 24 | Arlington TX | ||
| 9/26/2015 | Tarleton State (3-7,1-6) | 46 | at | Midwestern State | 63 | |||
| 10/3/2015 | Midwestern State | 29 | at | Angelo State (7-4,4-4) | 20 | |||
| 10/10/2015 | West Texas A&M (6-4,4-3) | 17 | at | Midwestern State | 24 | |||
| 10/17/2015 | Humboldt State (10-2) | 10 | at | Midwestern State | 35 | GNWAC | ||
| 10/24/2015 | Midwestern State | 14 | at | Texas A&M-Commerce (8-4,7-1) | 27 | |||
| 10/31/2015 | Texas A&M-Kingsville (2-9,1-7) | 41 | at | Midwestern State | 49 | |||
| 11/7/2015 | Eastern New Mexico (6-6,3-5) | 21 | at | Midwestern State | 26 | |||
| 11/14/2015 | Midwestern State | 37 | at | Texas A&M-Commerce (8-4,7-1) | 33 | |||
| 11/28/2015 | Colorado State-Pueblo (12-2) | 26 | at | Midwestern State | 17 | NCAA D2 Championship - Second Round | RMAC |
| vs Midwestern State | vs Other Opponents | Midwestern State compared to OOs | |
| Record: | 2-10 | 79-43 | |
| Points Scored: | 23.42 | 38.39 | 14.97 |
| Points Allowed: | 30.75 | 28.99 | 1.76 |
| Margin: | -7.33 | 9.40 | 16.73 |
| Total Points: | 54.17 | 67.38 | -13.21 |