| 9/1/2012 | Langston | 14 | vs | Ark Pine Bluff (10-2) | 17 | Little Rock AR | vs SWAC | |
| 9/8/2012 | Langston | 19 | vs | Bacone (6-4,3-1) | 0 | Tulsa OK | ||
| 9/15/2012 | Langston | 7 | at | St Xavier (11-2) | 37 | at MSFA | ||
| 9/22/2012 | Langston | 0 | at | Lamar (4-8) | 31 | at SLC | ||
| 9/29/2012 | Southern Nazarene (1-9) | 14 | at | Langston | 17 | GAC (D2) | ||
| 10/6/2012 | Langston | 40 | at | Wayland Baptist (2-7,1-3) | 0 | |||
| 10/13/2012 | Texas College (3-8,2-2) | 7 | at | Langston | 14 | |||
| 10/27/2012 | Langston | 11 | at | McMurry (8-3) | 29 | at D2Ind | ||
| 11/3/2012 | Southwestern Assemblies of God (3-7,0-4) | 7 | at | Langston | 21 | |||
| 11/10/2012 | Langston | 27 | at | Panhandle State (3-6) | 20 | at D2Ind |
| vs Langston | vs Other Opponents | Langston compared to OOs | |
| Record: | 4-6 | 47-50 | |
| Points Scored: | 16.20 | 24.95 | 8.75 |
| Points Allowed: | 17.00 | 27.81 | -10.81 |
| Margin: | -0.80 | -2.86 | -2.06 |
| Total Points: | 33.20 | 52.76 | -19.56 |