| 9/1/2012 | Waynesburg | 34 | at | Muskingum (3-7) | 23 | at OAC | ||
| 9/8/2012 | Frostburg State (3-7) | 7 | at | Waynesburg | 21 | E8 | ||
| 9/15/2012 | Waynesburg | 35 | at | St Vincent (0-10,0-8) | 14 | |||
| 9/22/2012 | Thomas More (7-3,6-2) | 10 | at | Waynesburg | 14 | |||
| 9/29/2012 | Waynesburg | 20 | at | Thiel (3-7,3-5) | 19 | |||
| 10/6/2012 | Grove City (6-4,5-3) | 14 | at | Waynesburg | 21 | |||
| 10/13/2012 | Waynesburg | 23 | at | Bethany WV (3-7,3-5) | 21 | |||
| 10/20/2012 | Waynesburg | 21 | at | Geneva (3-7,3-5) | 20 | |||
| 10/27/2012 | Westminster PA (3-6,2-6) | 16 | at | Waynesburg | 42 | |||
| 11/10/2012 | Washington & Jefferson (8-3,7-1) | 31 | at | Waynesburg | 14 | |||
| 11/17/2012 | Carnegie Mellon (6-5) | 24 | at | Waynesburg | 28 | ECAC Bowl Game | UAA |
| vs Waynesburg | vs Other Opponents | Waynesburg compared to OOs | |
| Record: | 1-10 | 44-56 | |
| Points Scored: | 18.09 | 23.28 | 5.19 |
| Points Allowed: | 24.82 | 24.67 | 0.15 |
| Margin: | -6.73 | -1.39 | 5.34 |
| Total Points: | 42.91 | 47.95 | -5.04 |