| 9/1/2012 | Puget Sound (0-9) | 7 | at | Sewanee | 30 | NWC | ||
| 9/8/2012 | Washington and Lee (8-3) | 28 | at | Sewanee | 6 | ODC | ||
| 9/15/2012 | Sewanee | 17 | at | Maryville (6-4) | 24 | at USASC | ||
| 9/22/2012 | Sewanee | 31 | at | Austin (2-8) | 10 | at D3Ind | ||
| 9/29/2012 | Willamette (8-2) | 28 | at | Sewanee | 24 | NWC | ||
| 10/6/2012 | Centre (6-4,1-3) | 10 | at | Sewanee | 7 | |||
| 10/13/2012 | Sewanee | 28 | at | Millsaps (7-3,3-1) | 42 | |||
| 10/20/2012 | Sewanee | 31 | at | Birmingham-Southern (7-3,3-1) | 19 | |||
| 10/27/2012 | Rhodes (6-3,2-2) | 14 | at | Sewanee | 10 | |||
| 11/3/2012 | Trinity TX (7-3) | 48 | at | Sewanee | 7 | D3Ind |
| vs Sewanee | vs Other Opponents | Sewanee compared to OOs | |
| Record: | 7-3 | 50-39 | |
| Points Scored: | 23.00 | 29.40 | 6.40 |
| Points Allowed: | 19.10 | 27.36 | -8.26 |
| Margin: | 3.90 | 2.04 | -1.86 |
| Total Points: | 42.10 | 56.76 | -14.66 |