| 9/1/2012 | Hampden-Sydney | 20 | at | Averett | 6 | vs ODC | ||
| LaGrange | 14 | at | Birmingham-Southern | 41 | @ SCAC | |||
| Salisbury | 40 | at | Christopher Newport | 16 | vs E8 | |||
| Emory & Henry | 45 | at | Ferrum | 36 | vs ODC | |||
| Greensboro | 14 | at | Guilford | 13 | @ ODC | |||
| Maryville | 33 | at | Huntingdon AL | 49 | @ D3Ind | |||
| Washington & Jefferson | 23 | at | Methodist | 6 | vs TPAC | |||
| Ohio Northern | 13 | at | North Carolina Wesleyan | 16 | vs OAC | |||
| 9/8/2012 | Greensboro | 7 | at | Bridgewater VA | 33 | @ ODC | ||
| Methodist | 34 | at | Guilford | 21 | @ ODC | |||
| Christopher Newport | 20 | at | Hampden-Sydney | 42 | @ ODC | |||
| Millsaps | 54 | at | LaGrange | 7 | vs SCAC | |||
| Emory & Henry | 21 | at | Maryville | 8 | vs ODC | |||
| Averett | 6 | at | Randolph-Macon | 21 | @ ODC | |||
| Ferrum | 14 | at | Shenandoah | 7 | @ ODC | |||
| North Carolina Wesleyan | 14 | at | Southern Virginia | 24 | @ NAIAInd (NAIA) | |||
| 9/15/2012 | Guilford | 45 | at | Averett | 35 | vs ODC | ||
| Methodist | 20 | at | Emory & Henry | 34 | @ ODC | |||
| Southern Virginia | 7 | at | Ferrum | 20 | vs NAIAInd (NAIA) | |||
| Apprentice | 13 | at | Greensboro | 20 | vs D3Ind | |||
| Huntingdon AL | 62 | at | LaGrange | 17 | vs D3Ind | |||
| Sewanee | 17 | at | Maryville | 24 | vs SCAC | |||
| North Carolina Wesleyan | 6 | at | Salisbury | 69 | @ E8 | |||
| Christopher Newport | 20 | at | Shenandoah | 7 | @ ODC | |||
| 9/29/2012 | Ferrum | 49 | at | Averett | 28 | |||
| North Carolina Wesleyan | 13 | at | LaGrange | 40 | ||||
| Christopher Newport | 45 | at | Maryville | 31 | ||||
| Greensboro | 34 | at | Methodist | 33 | ||||
| 10/6/2012 | Ferrum | 31 | at | Christopher Newport | 38 | |||
| Maryville | 41 | at | Greensboro | 6 | ||||
| Averett | 14 | at | LaGrange | 7 | ||||
| Methodist | 34 | at | North Carolina Wesleyan | 13 | ||||
| 10/13/2012 | LaGrange | 20 | at | Christopher Newport | 6 | |||
| North Carolina Wesleyan | 35 | at | Ferrum | 51 | ||||
| Averett | 16 | at | Greensboro | 18 | ||||
| Maryville | 28 | at | Methodist | 24 | ||||
| 10/20/2012 | Christopher Newport | 28 | at | Averett | 13 | |||
| LaGrange | 17 | at | Maryville | 13 | ||||
| Ferrum | 21 | at | Methodist | 13 | ||||
| Greensboro | 23 | at | North Carolina Wesleyan | 45 | ||||
| 10/27/2012 | Maryville | 31 | at | Averett | 7 | |||
| Ferrum | 35 | at | Greensboro | 12 | ||||
| Methodist | 26 | at | LaGrange | 23 | ||||
| Christopher Newport | 17 | at | North Carolina Wesleyan | 10 | ||||
| 11/3/2012 | Greensboro | 16 | at | Christopher Newport | 22 | |||
| LaGrange | 24 | at | Ferrum | 48 | ||||
| North Carolina Wesleyan | 13 | at | Maryville | 34 | ||||
| Averett | 27 | at | Methodist | 33 | 2OT | |||
| 11/10/2012 | Methodist | 30 | at | Christopher Newport | 29 | |||
| Maryville | 22 | at | Ferrum | 17 | ||||
| LaGrange | 27 | at | Greensboro | 31 | ||||
| Averett | 21 | at | North Carolina Wesleyan | 32 | ||||
| 11/17/2012 | Christopher Newport | 14 | at | Mount Union | 72 | Div 3 Playoffs 1st Round | @ OAC |